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Immunopathogenic Mechanisms of Interstitial Nephritis

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Immunology of Renal Disease

Part of the book series: Immunology and Medicine Series ((IMME,volume 16))

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Abstract

Primary tubulointerstitial nephritis causes a significant proportion of both acute and chronic renal disease1. Advances in our knowledge of clinicopathological correlates, moreover, have also established a prognostic importance for the tubulointerstitium in other primary types of renal disease2. Studies evaluating renal function in primary glomerular disease, for example, have demonstrated the importance of tubulointerstitial damage in determining the ultimate prognosis2,3. In some settings, indices of tubulointerstitial damage display a better correlation with glomerular filtration rate than do indices of glomerular damage4,5. Such findings have stimulated a growing interest in understanding mechanisms of injury to the tubulointerstitium.

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Authors
  1. C. M. Meyers
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  2. C. J. Kelly
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Editors and Affiliations

  1. Renal Unit, Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK

    C. D. Pusey

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Meyers, C.M., Kelly, C.J. (1991). Immunopathogenic Mechanisms of Interstitial Nephritis. In: Pusey, C.D. (eds) Immunology of Renal Disease. Immunology and Medicine Series, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3902-1_13

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  • DOI: https://doi.org/10.1007/978-94-011-3902-1_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5738-7

  • Online ISBN: 978-94-011-3902-1

  • eBook Packages: Springer Book Archive

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