Abstract
Apolipoprotein (apo) E, a 34 000 molecular weight protein that is the product of a single gene on chromosome 19 (for review, see ref. 1), exists in three major forms. Its heterogeneity results from a single amino acid substitution at residue 112 or 158. The common isoform, apoE3, has cysteine at residue 112 and arginine at residue 158. The apoE4 isoform, which has been linked to Alzheime’s disease, differs from apoE3 only at residue 112, where it possesses arginine. The apoE2 isoform, associated with type III hyperlipoproteinaemia1, differs from apoE3 only at residue 158, where it possesses cysteine. Apolipoproteins E3 and E4 bind normally to the low density lipoprotein (LDL) receptor, whereas apoE2 does not.
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Mahley, R.W. (1995). Apolipoprotein E and Alzheimer’s disease. In: Assmann, G. (eds) HDL Deficiency and Atherosclerosis. Developments in Cardiovascular Medicine, vol 174. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6585-3_6
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DOI: https://doi.org/10.1007/978-94-011-6585-3_6
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