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Dexamethasone Suppression Test

  • Chapter
Handbook of Psychiatric Diagnostic Procedures Vol. I

Abstract

The overnight dexamethasone suppression test (DST) was first proposed as a diagnostic aid for endogenous depression or melancholia in 1976 [1,2] and was further standardized in 1981 [3]. It has attracted wide interest in the past few years as its use passed out of investigational units into clinical practice. As with other examples of technology transfer from research to clinical settings, second-generation reports that either strongly confirm or seriously question the utility of the DST can be found in recent literature. In many ways, this situation reminds us of the era soon after the tricyclic antidepressant drugs were introduced: About one third of the reported studies failed to demonstrate the antidepressant efficacy of imipramine [4]. Many of the same reasons for confusion at that time (diagnostic heterogeneity and reliability issues) are responsible for the uncertainty today about the DST. There are also technical issues related to the test itself that have not always been properly understood.

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Carroll, B.J. (1984). Dexamethasone Suppression Test. In: Handbook of Psychiatric Diagnostic Procedures Vol. I. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6725-3_1

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  • DOI: https://doi.org/10.1007/978-94-011-6725-3_1

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