Abstract
Efficient fat absorption requires the rapid flux of poorly soluble and insoluble molecules through the very thick unstirred water layer coating the absorptive mucosa of the small intestine. Fat digestion involves a chemical event — the hydrolysis of ester lipids by lipase and a non-specific esterase; and a physical event — the micellar dispersion of these lipolytic products by bile acids. For some lipids, e.g. trioctanoin, only chemical hydrolysis is necessary since the digestive products are water soluble. Other insoluble lipids, such as cholesterol, are not altered chemically during digestion, but micellar solubilization is required for absorption.
The author’s work is supported by grants AM 16770 and AM 6908 from the National Institutes of Health as well as grants-in-aid from the Mead Johnson Company and the Eli Lilly Foundation.
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References
Ammon, H. V. and Phillips, S. F. (1973). Inhibition of colonic water and electrolyte absorption by fatty acids in man. Gastroenterology, 65, 744
Bikhazi, A. F. and Higuchi, W. I. (1970). Interfacial barrier limited interphase transport of cholesterol in the aqueous polysorbate 80—hexadecane system. J. Pharm. Sci., 59, 744
Borgström, B. (1967). Partition of lipids between emulsified oil and micellar phases of glyceride—bile salt dispersions. J. Lipid Res., 8, 598
Borgström, B., Dahlqvist, A., Lundh, G. and Sjövall, S. (1957). Studies of intestinal digestion and absorption in the human. J. Clin. Invest., 36, 1521
Cowen, A. E., Korman, M. G., Hofmann, A. F. and Cass, O. W. (1975). Metabolism of lithocholate in man. I. Biotransformation and biliary excretion of intravenously administered lithocholate, lithocholylglycine, and their sulfates. Gastroenterology (In press)
Dreher, K. D., Schulman, J. H. and Hofmann, A. F. (1967). Surface chemistry of the monoglyceride—bile salt system: Its relationship to the function of bile salts in fat absorption. J. Colloid. Interfac. Sci., 25, 71
Fallat, R. W., Glueck, C. J., Mattson, F. and Lutmer, R. (1975). Sucrose polyester: a cholesterol lowering noncaloric unabsorbable synthetic fat food additive. Clin. Res., 23, 319a
Freeman, C. P. (1969). Properties of fatty acids in dispersions of emulsified bile salt and the significance of these properties in fat absorption in the pig and the sheep. Brit. J. Nutr., 23, 249
Go, V. L. W., Poley, J. R., Hofmann, A. F. and Summerskill, W. H. J. (1970). Disturbances in fat digestion induced by acidic jejunal pH due to gastric hypersecretion in man. Gastroenterology, 58, 638
Harkins, R. W., Hagerman, L. M. and Sarett, H. P. (1965). Absorption of dietary fats by the rat in cholestyramine-induced steatorrhea. J. Nutrition, 87, 85
Hoffman, N. E. (1971). The intestinal absorption of micellar and non-micellar lipid. Thesis, University of Western Australia
Hofmann, A. F. (1963). The behavior and solubility of monoglycerides in dilute, micellar bile salt solution. Biochim. Biophys. Acta, 70, 306
Hofmann, A. F. (1968). Molecular association in fat digestion. Interaction in bulk of monoolein, oleic acid and sodium oleate with dilute, micellar bile salt solutions. Adv. in Chem., 84, 53
Hofmann, A. F. and Borgström B. (1964). The intraluminal phase of fat digestion in man: The lipid content of the micellar and oil phases of intestinal content obtained during fat digestion and absorption. J. Clin. Invest., 43, 247
Hofmann, A. F. and Mekhjian, H. S. (1973). Bile acids and the intestinal absorption of fat and electrolytes in health and disease. In: Nair and Kritchevsky (eds). The Bile Acids, pp. 103–152 (New York: Plenum Press)
Knoebel, L. K. and Ryan, J. M. (1963). Digestion and mucosal absorption of fat in normal and bile-deficient dogs. Amer. J. Phys., 204, 509
Linscheer, W. G. (1972). Optimal micellar solubilization of oleic acid, an undesirable condition for maximal absorption. (Abst.) Gastroenterology, 62, 777
Lucassen, J. (1966). Hydrolysis and precipitates in carboxylate soap solutions. J. Phys. Chem., 70, 1824
Morgan, R. G. H. and Hofmann, A. F. (1970). Synthesis and metabolism of glyceryl-3H-triether, a nonabsorbable oil phase marker for lipid absorption studies. J. Lipid Res., 11, 223
Mukerjee, P. (1971). Analysis of distribution model for micellar solubilization using thermodynamics of small systems: nonideality of solubilization of benzoic acid derivatives in non-ionic surfactants. J. Pharm. Sci., 60, 1531
Neiderhiser, D. H. and Roth, H. P. (1970). Effect of phospholipase on cholesterol solubilization by lecithin in a bile salt solution. Gastroenterology, 58, 26
Porter, H. P., Saunders, D. R., Tytgat, G., Brunser, O. and Rubin, C. E. (1970). Fat absorption in bile fistula man: A morphological and biochemical study. Gastroenterology, 60, 1008
Sallee, V. L. (1974). Apparent monomer activity of saturated fatty acids in micellar bile salt solutions measured by a polyethylene partitioning system. J. Lipid Res., 15, 56
Simmonds, W. J. (1974). Absorption and lipids. In: Jacobsen and Shanbour (eds.). MTP International Review of Science; Physiology Series One, Vol. 4, Gastrointestinal Physiology, p. 343 (London: Butterworths and Baltimore: University Park Press)
Small, D. M. (1968). A classification of biologic lipids based upon their interaction in aqueous systems. J. American Oil Chemists Soc., 45, 108
Stein, W. D. (1969). The Movement of Molecules across Cell Membranes, p. 369 (New York: Academic Press)
Verkade, P. E. and Meerburg, W. (1955). The solubility of some normal saturated fatty acids in an aqueous sodium glycocholate solution. Rec. Trav. Chim. Pays., 74, 263
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Hofmann, A.F. (1976). Fat Digestion: The Interaction of Lipid Digestion Products with Micellar Bile Acid Solutions. In: Rommel, K., Goebell, H., Böhmer, R. (eds) Lipid Absorption: Biochemical and Clinical Aspects. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7176-2_1
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DOI: https://doi.org/10.1007/978-94-011-7176-2_1
Publisher Name: Springer, Dordrecht
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