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Intracellular amino acids and energy metabolism in catabolic patients with regard to muscle tissue

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Advances in Parenteral Nutrition

Abstract

Weakness and tiring easily are the most common symptoms of surgical convalescence. This response is more severe and prolonged than the associated bed-rest and decreased nutrition can account for. A prominent feature of acute surgical catabolism is an obligatory negative nitrogen balance, associated with protein breakdown. Despite the repeated confirmation of these findings since the first reports in 1930, the underlying mechanism and physiological significance remains obscure. The observed clinical weakness and fatigue may be the result of the negative nitrogen balance which is largely due to the breakdown of muscle protein.

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References

  1. Bergström, J. (1962). Muscle electrolytes in man. Scand. J. Clin. Lab. Invest., 14, (Suppl.), 68

    Google Scholar 

  2. Edwards, R. H. (1971). Percutaneous needle biopsy of skeletal muscle in diagnosis and research. Lancet, ii, 593

    Google Scholar 

  3. Bergström, J. (1975). Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand. J. Clin. Lab. Invest., 35, 609

    Article  Google Scholar 

  4. Bergström, J. and Friden, A. M. (1975). The effect of hydrochlorothiazide and amiloride administered together on muscle electrolytes in normal subjects. Acta Med. Scand., 197, 415

    Article  Google Scholar 

  5. Bergström, J., Fürst, P., Noree, L. O. and Vinnars, E. (1974). The intracellular free amino acid concentration in human muscle tissue. J. Appl. Physiol., 36, 693

    Google Scholar 

  6. Bergström, J., Alvestrand, A., Fürst, P., Hultman, E., Sahlin, K., Vinnars, E. and Widström, A. (1976). Influence of severe potassium depletion and subsequent repletion with potassium on muscle electrolytes, metabolites and amino acids in man. Clin. Sci. Mol. Med., 51, 589

    Google Scholar 

  7. Cotlove, E. (1963). Determination of the true chloride content of biological fluids and tissues. Anal. Chem., 35, 101

    Article  Google Scholar 

  8. Bolte, H. D., Riecker, G. and Rohl, D. (1963). Messungen des Membranpotentials an einzelnen guergestrieften Musckelzellen der Menshen in situ. Klin. Wochenschr., 41, 356

    Article  CAS  Google Scholar 

  9. Cunningham, J. N., Jr., Carter, N. W., Rector, F. C., Jr. and Seldin, D. W. (1971). Resting transmembrane potential in normal subjects and severely ill patients. J. Clin. Invest., 50, 49

    Article  CAS  Google Scholar 

  10. Bolte, H. D., Becker, E. and Volker, W. (1972). Changes in ionic permeability of skeletal and heart muscle cellular membranes in renal insufficiency. In R. Kluthe, G. Berlyne and B. Barton (eds.). Uremia, pp. 14–18. (Stuttgart: Thieme Verlag)

    Google Scholar 

  11. Cotton, J. R., Carter, N. W. and Knochel, J. P. (1976). Muscle membrane potential [Em]; A possible index of adequate dialysis. In Ninth Annual meeting of the American Society of Nephrology, p. 29

    Google Scholar 

  12. Campion, D. S., Lynch, L. J., Rector, F. C. Jr., Carter, N. and Shires, G. T. (1969). Effect of hemorrhagic shock on transmembrane potential. Surgery, 66, 1051

    CAS  Google Scholar 

  13. Shires, G. T., Carrico, C. J., Baxter, C. R., Giesecke, A. H. and Jenkins, M. J. (1970). Principles in treatment of severely injured patients. In E. C. Welch (ed). Advances in Surgery. Vol. IV, p. 255. (Chicago: Year Book Med.)

    Google Scholar 

  14. Harris, R. C., Hultman, E. and Nordesjö, L. O. (1974). Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of muscles quadriceps femoris of man at rest. Methods and variance of values. Scand. J. Clin. Lab. Invest., 33, 109

    Article  CAS  Google Scholar 

  15. Munro, H. (1970). Free amino acid pools and their role in regulation. In H. N. Munro (ed.). Mammalian Protein Metabolism, pp. 299–386 (New York: Academic Press)

    Google Scholar 

  16. Bergström, J., Fürst, P. and Noree, L. (1972). The effect of peritoneal dialysis on the intracellular free amino acids in muscle tissue from uremic patients. Proc. Eur. Dial. Transpl. Assoc, 9, 393

    Google Scholar 

  17. Vinnars, E., Fürst, P., Bergström, J. and von Francken, I. (1976). Intracellular free amino acids in normal man and in different clinical conditions. In A. W. Wilkinson and D. Cuthbertson (eds.). Metabolism and the Response to Injury, pp. 336–350. (London: Pitman Press)

    Google Scholar 

  18. Vinnars, E., Bergström, J. and Fürst, P. (1975). Influence of the postoperative state on the intracellular free amino acids in human muscle tissue. Ann. Surg., 182, 665

    Article  CAS  Google Scholar 

  19. Fürst, P., Bergström, J., Kinney, J. M. and Vinnars, E. (1977). Nutrition in postoperative catabolism. Proc. Nutritional Aspects of the Care of the Critically Ill. (In press)

    Google Scholar 

  20. Bergström, J., Fürst, P., Noree, L. O. and Vinnars, E. (1975). Intracellular free amino acids in uremic patients as influenced by amino acid supply. Kidney Int., 7, S-354

    Google Scholar 

  21. Bergström, J., Fürst, P., Ahlberg, M. and Noree, L. O. (1977). Nutrition in renal failure. Proc. Nutritional Aspects of the Care of the Critically Ill. (In press)

    Google Scholar 

  22. Bergström, J., Alvestrand, A. and Fürst, P. (1977). Amino acids levels and effect of amino acid supplements. Proc. On Growth Retardation in Children with Kidney Failure (In press)

    Google Scholar 

  23. Munro, H. N. (1964). General aspects of the regulation of protein metabolism by diet and hormones. In H. N. Munro and J. B. Allison (eds.). Mammalian Protein Metabolism pp. 412–491. (New York: Academic Press)

    Google Scholar 

  24. Roch-Nordlund, A. E., Alinder, I., Ahlberg, M., Fürst, P. and Nerger, G. (1974). Nitrogen metabolism in diabetic patients. Acta Endocrinol, 77, (Suppl.), 190

    Google Scholar 

  25. Vinnar, E., Bergström, J., Fürst, P., Holmström, B. and Schildt, B. (1977). Influence of parenteral nutrition on nitrogen balance and intracellular amino acid pattern in muscle tissue in colon surgery (carcinoma). Proc. Balanced Nutrition and Therapy. (In press)

    Google Scholar 

  26. Harper, A. E. (1964). Amino acid toxicities and imbalances. In H. N. Munro and J. B. Allison (eds.). Mammalian Protein Metabolism, pp. 87–134. (New York: Academic Press)

    Google Scholar 

  27. O’Keefe, S. J. D. and Sender, P. M. (1974). ‘Catabolic’ loss of body nitrogen in response to surgery. Lancet, ii, 1035

    Article  Google Scholar 

  28. Millward, D. J., Garlick, P. J., Dickson, O. N. and Waterlow, J. C. (1976). The relative importance of muscle protein synthesis and breakdown in the regulation of muscle mass. Biochem. J., 156, 185

    CAS  Google Scholar 

  29. Clement, C. Y. Ip. and Harper, A. E. (1974). Liver polysome profiles and protein synthesis in rats fed a threonine-imbalanced diet. J. Nutr., 104, 252

    Google Scholar 

  30. Noda, K., Taniguchi, H. and Kitasaka, R. (1975). Effect of amino acid imbalance on protein synthesis of skeletal muscle and liver in rats. Nutr. Rep. Inter., 11, 129

    CAS  Google Scholar 

  31. Gaetani, S., Paolucci, A. M., Spadoni, M. A. and Tomassi, G. (1964). Activity of amino acid-activating enzymes in tissues from protein-depleted rats. J. Nutr., 84, 173

    CAS  Google Scholar 

  32. Bergström, J., Boström, H., Fürst, P., Hultman, E. and Vinnars, E. (1976). Preliminary studies of energy-rich Phosphagens in muscle from severely ill patients. Critical Care Med., 4, 197

    Article  Google Scholar 

  33. Fürst, P., Bergström, J., Hultman, E. and Vinnars, E. (1976). Intermediary energy metabolism for the catabolic state with special regard to muscle tissue. In A. W. Wilkinson and D. Cuthbertson (eds.). Metabolism and the Response to Injury, pp. 94–112. (London: Pitman Press)

    Google Scholar 

  34. Karlsson, J., Willerson, J. R., Leshin, S. J., Mullins, C. B. and Mitchell, J. H. (1975). Skeletal muscle metabolites in patients with cardiogenic shock or severe congestive heart failure. Scand. J. Clin. Lab. Invest., 35, 73

    Article  CAS  Google Scholar 

  35. Atkinson, D. E. (1968). The energy charge of the adenylate pool as a regulator parameter. Interaction with feedback modifiers. Biochemistry, 7, 4030

    Article  CAS  Google Scholar 

  36. Harper, A. E., Bencuengh, N. J. and Wohlhmeter, R. M. (1970). Effects of ingestion of disproportionate amounts of amino acids. Physiol. Rev., 50, 128

    Google Scholar 

  37. O’Keefe, S. J. D., Sender, P. M. and James, W. P. T. (1974). Catabolic loss of body nitrogen in response to surgery. Lancet, ii, 1035

    Article  Google Scholar 

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Authors
  1. P. Fürst
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  2. J. Bergström
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  3. E. Vinnars
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  4. B. Schildt
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  5. B. Holmström
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Editor information

Editors and Affiliations

  1. Department of Surgery, University of Newcastle-Upon-Tyne, UK

    Ivan D. A. Johnston

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© 1978 MTP Press Ltd

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Fürst, P., Bergström, J., Vinnars, E., Schildt, B., Holmström, B. (1978). Intracellular amino acids and energy metabolism in catabolic patients with regard to muscle tissue. In: Johnston, I.D.A. (eds) Advances in Parenteral Nutrition. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7188-5_6

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  • DOI: https://doi.org/10.1007/978-94-011-7188-5_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-7190-8

  • Online ISBN: 978-94-011-7188-5

  • eBook Packages: Springer Book Archive

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