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Infectious and Immunologic Diseases Affecting the Developing Nervous System

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Brain

Abstract

In the preceding chapter Dr. Johnson has illustrated the variety of disorders of the developing nervous system which can be produced experimentally with several viral infections. In order to keep his presentation in some perspective related to human diseases, we shall review briefly what is known about infections of the human in utero or perinatally.

Supported in part by research grants number GM 13543-12 and HD 02274-11 from the National Institutes of Health, U.S. Public Health Service.

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References

  • Altshuler, G.: Toxoplasmosis as a cause of hydranencephaly. Am. J. Dis. Child. 125: 251 - 252 (1973).

    PubMed  CAS  Google Scholar 

  • Beer, A.E. and Billingham, R.E.: Immunobiology of mammalian reproduction. Adv. Immunol. 14: 1 - 84 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Berenberg, W. and Nakervis, G.: Long-term follow-up of cytomegalic inclusion disease of infancy. Pediatrics 46: 403 - 410 (1970).

    PubMed  CAS  Google Scholar 

  • Boniuk, M. and Zimmerman, L.E.: Ocular pathology in the rubella syndrome. Arch. Ophthalmol. 77: 455 - 473 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Bragonier, J.R., Frank, M. M. and Brent, R.L.: Production of congenital malformations using tissue antisera. VIII. Effectiveness of structurally modified anti-kidney antibodies. Fed. Proc. 29: 828 (1970).

    Google Scholar 

  • Breyere, E.J. and Shulman, S.: Immunology of reproduction. In Amos, Progress in Immunology, First International Congress of Immunology, pp. 1227 - 1232 ( Academic Press, New York 1971 ).

    Google Scholar 

  • Brown, G.C.: Recent advances in the viral aetiology of congenital anomalies. Adv. Teratol. 1: 5580 (1966).

    Google Scholar 

  • Crome, L.: Hydrencephaly. Dev. Med. Child. Neurol. 14: 224 - 234 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Crome, L. and Sylvester, P.E.: Hydranencephaly (hydrencephaly). Arch. Dis. Child. 33: 235 - 245 (1958).

    Article  PubMed  CAS  Google Scholar 

  • Demian, S.D.A., Donnelly, W.H., Jr. and Monif, G.R.G.: Coexistent congenital cytomegalovirus and toxoplasmosis in a stillborn. Am. J. Dis. Child. 125: 420 - 421 (1973).

    PubMed  CAS  Google Scholar 

  • Dennis, J.P. and Alvord, E.C., Jr.: Microcephaly with intracranial calcification and subependymal ossification: Radiologie and clinicopathologic correlation. J. Neuropathol. Exp. Neurol. 20: 412 - 426 (1961).

    Article  Google Scholar 

  • Embil, J.A., Ozere, R.L. and Haldane, E.V.: Congenital cytomegalovirus infection in two siblings from consecutive pregnancies. J. Pediatr. 77: 417 - 421 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Ford, F.R.: Diseases of the Nervous System in Infancy, Childhood and Adolescence. (Charles C. Thomas, Publ., Springfield 1945 ).

    Google Scholar 

  • Florman, A.L., Gershon, A.A., Blackett, P.R. and Nahmias, A. J.: Intrauterine infection with herpes simplex virus: Resultant congenital malformations. JAMA 225: 129 - 132 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Globus, J.H.: A contribution to the histopathology of porencephalus. Arch. Neurol. Psychiatr. 6: 652 - 668 (1921).

    Google Scholar 

  • Gregg, N.M.: Congenital cataract following German measles in the mother. Trans. Ophthalmol. Soc. Austral. 3: 35 - 46 (1941).

    Google Scholar 

  • Halsey, J.H., Jr., Allen. N. and Chamberlin. H.R.: The morphogenesis of hydranencephaly. J. Neurol. Sci. 12: 187 - 217 (1971).

    Google Scholar 

  • Hamby, W.B., Krauss, R.F. and Beswick, W.F.: Hydranencephaly: clinical diagnosis. Presentation of seven cases. Pediatrics 6: 371 - 383 (1950).

    PubMed  CAS  Google Scholar 

  • Hanshaw. J.B.: Developmental abnormalities associated with congenital cytomegalovirus infection. Adv. Teratol. 4: 64 - 93 (1970).

    Google Scholar 

  • Hague. I.U. and Glassauer. F.E.: Hydranencephaly in twins. N.Y. State J. Med. 69: 1210 - 1214 (1969).

    Google Scholar 

  • Hardy, J.B., McCracken. G.H. Jr.. Gilkeson. M.R. and Sever, J. L.: Adverse fetal outcome following maternal rubella after the first trimester. JAMA 207: 2414 - 2420 (1969).

    CAS  Google Scholar 

  • Herndon, R.M., Johnson, R.T., Davis. L.E., and Descalzi, L.R.: Ependymitis in mumps virus meningitis. Electron microscopical studies of cerebrospinal fluid. Arch. Neurol. 30: 475 - 479 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Jaffe, R.H.: Traumatic porencephaly. Arch. Pathol. 8: 787 - 799 (1929).

    Google Scholar 

  • Johnson, R.T.: Effects of viral infection on the developing nervous system. N. Engl. J. Med. 287: 599 - 604 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Johnson, R.T.: Hydrocephalus and viral infections. Dev. Med. Child Neurol. 17: 807 - 816 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Katz, S.L.: Slow Virus Infections (64th Ross Conference on Pediatric Research, Columbus 1973 ).

    Google Scholar 

  • Leech. R.W., and Alvord, E.C., Jr.: Wallerian degeneration in the premature human. J. Neuropathol. Exp. Neurol. 34: 92 (1975).

    Google Scholar 

  • Leech, R.W., and Kohnen, P.: Subependymal and intraventricular hemorrhages in the newborn. Am. J. Pathol. 77: 465 - 476 (1975).

    Google Scholar 

  • Leung, C.C.K., Urdaneta, A., Jensen, M., and Brent, R.L.: The production of congenital malformations and nephrotoxic serum nephritis. Fed. Proc. 32: 982 (1973).

    Google Scholar 

  • Lindenberg, R., and Swanson, P.D.: Infantile hydranencephaly — A report of five cases of infarction of both cerebral hemispheres in infancy. Brain 90: 839 - 850 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Muir, C.S.: Hydranencephaly and allied disorders: a study of cerebral defects in Chinese children. Arch. Dis. Child. 34: 231 - 246 (1959).

    Article  PubMed  CAS  Google Scholar 

  • Navin, J.J., and Angevine, J.M.: Congenital cytomegalic inclusion disease with porencephaly. Neurology (Minneap.) 18: 470 - 472 (1968).

    CAS  Google Scholar 

  • Osburn, B.I., Johnson, R.T., Silverstein, A.M., Prendergast. R.A., Jochim, M.M., and Levy, S.E.: Experimental viral-induced congenital encephalopathies. II. The pathogenesis of blue tongue vaccine virus infection in fetal lambs. Lab. Invest. 25: 206 - 210 (1971a).

    CAS  Google Scholar 

  • Osburn. B.I., Silverstein, A.M., Prendergast, R.A., Johnson, R. T., and Parshall, C.J., Jr.: Experimental viral-induced congenital encephalopathies. I. Pathology and hydranencephaly and porencephaly caused by blue tongue vaccine virus. Lab. Invest. 25: 197 - 205 (1971b).

    Google Scholar 

  • Patten, C.A., Grant, F.C., and Yaskin, J.C.: Porencephaly: diagnosis and treatment. Arch. Neurol. Psychiatr. 37: 108 - 136 (1937).

    Google Scholar 

  • Rorke, L.B.: Nervous system lesions in the congenital rubella syndrome. Arch. Otolaryngol. 98: 249 - 251 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Rorke, L.B., and Spiro, A.J.: Cerebral lesions in congenital rubella syndrome. J. Pediatr. 70: 243 - 255 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Savage, M.O., Mossa, A., and Gordon. R.R.: Maternal varicella infection as a cause of fetal malformations. Lancet 1: 352 - 354 (1973).

    Article  PubMed  CAS  Google Scholar 

  • Shaw, C.M.: Subependymal germinolysis. J. Neuropathol. Exp. Neurol. 32: 153 (1973).

    Google Scholar 

  • Shaw, C.M., and Alvord, E.C.. Jr.: Subependymal germinolysis. Arch. Neurol. 31: 374 - 381 (1974).

    Article  PubMed  CAS  Google Scholar 

  • Shaw, C.M.. and Sumi, S.M.: Nonviral intranuclear filamentous inclusions. Arch. Neurol. 32: 428 - 432 (1975).

    Article  PubMed  CAS  Google Scholar 

  • South, M.A., Tomkins, W.A.F., Morris, C.R., and Rawls, W.E.: Congenital malformation of the central nervous system associated with genital (type 2) herpesvirus. J. Pediatr. 75: 13 - 18 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Sumi, S.M.: Reaction of the immature brain to injury. pp. 177-189 in Angle and Bering, Physical Trauma as an Etiological Agent in Mental Retardation (U.S. Government Printing Office, Washington. D.C. 1970 ).

    Google Scholar 

  • Sumi, S.M.. and Hager, H.: Electron microscopic study of the reaction of the newborn rat to injury. Acta Neuropathol. 10: 324 - 355 (1968a).

    Article  PubMed  CAS  Google Scholar 

  • Sumi, S.M., and Hager, H.: Electron microscopic features of an experimentally produced porencephalic cyst in the rat brain. Acta Neuropathol. 10: 336 - 346 (1968b).

    Article  PubMed  CAS  Google Scholar 

  • Tondury, G., and Smith, D.W.: Fetal rubella pathology. J. Pediatr. 68: 867 - 879 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Vander Eecken, H.M.: The Anastomoses Between the Leptomeningeal Arteries of the Brain. (Charles C. Thomas, Publ., Springfield 1959 ).

    Google Scholar 

  • Warkany. J.: Congenital Malformations. (Year Book Med. Publ., Chicago 1971 ).

    Google Scholar 

  • Weiser, R.S., Myrvik, Q.N., and Pearsall, N.N.: Fundamentals of Immunology for Students of Medicine and Related Sciences. pp. 263-272. ( Lea & Febiger, Philadelphia 1969 ).

    Google Scholar 

  • Weiss, M.H., Young, H.F., and McFarland, D.E.: Hydranencephaly of postnatal origin. J. Neurosurg. 32: 715 - 720 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Weller, T.H.: The cytomegaloviruses: ubiquitous agents with protean clinical manifestations. N. Engl. J. Med. 285: 203-214, 267 - 274 (1971).

    Google Scholar 

  • Williams, H.J.: Skull erosion complicating traumatic porencephaly in infancy. Am. J. Roentgenol. Radium Ther. Nucl. Med. 106: 129 - 132 (1969).

    PubMed  CAS  Google Scholar 

  • Yakovlev, P.I., and Wadsworth, R.C.: Double symmetrical porencephalies (schizencephalies). Trans. Am. Neurol. Assoc. 67: 24 - 29 (1941).

    Google Scholar 

  • Yakovlev, P.I., and Wadsworth, R.C.: Schizencephalies: a study of congenital clefts in the cerebral mantle. I. Clefts and fused lips. J. Neuropathol. Exp. Neurol. 5: 116 - 130 (1946a).

    Article  CAS  Google Scholar 

  • Yakovlev, P.I., and Wadsworth, R.C.: Schizencephalies: a study of congenital clefts in the cerebral mantle. II. Clefts with hydrocephalus and lips separated. J. Neuropathol. Exp. Neurol. 5: 169 - 206 (1946b).

    Article  PubMed  CAS  Google Scholar 

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Samuel R. Berenberg M.D.

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© 1977 Martinus Nijhoff, The Hague, Netherlands

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Alvord, E.C., Shaw, CM. (1977). Infectious and Immunologic Diseases Affecting the Developing Nervous System. In: Berenberg, S.R. (eds) Brain. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-8884-5_15

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  • DOI: https://doi.org/10.1007/978-94-011-8884-5_15

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-8221-8

  • Online ISBN: 978-94-011-8884-5

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