Abstract
Alveolar macrophages are believed to play a critical role in the maintenance of the integrity of the lungs by both ingesting potentially harmful agents, such as allergens and infectious microorganisms, and producing a number of specific mediators, such as reactive oxygen intermediates, arachidonic acid metabolites, chemotactic factors, and cytokines (1). These macrophages reside in a microenvironment which is rich in surfactant and they also contain this material (2, 3). Surfactant, comprising about 90% lipid, 8% protein, and 2% carbohydrates, is produced by type 2 epithelial alveolar cells; its main function is to reduce surface tension in the alveoli (4). Despite their strategic position outside the epithelial lining of the air spaces, alveolar macrophages are limited in their bactericidal activities compared to other phagocytes (5–7).
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© 1992 Springer Science+Business Media Dordrecht
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Geertsma, M.F., Broos, H.R., van den Barselaar, M.T., Nibbering, P.H., Van Furth, R. (1992). Ingestion of pulmonary surfactant by human monocytes inhibits their antibacterial functions. In: van Furth, R. (eds) Mononuclear Phagocytes. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-8070-0_40
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DOI: https://doi.org/10.1007/978-94-015-8070-0_40
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-4171-5
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