Abstract
A silicon-machined micromixer[1] has been coupled with electrospray ionisation mass spectrometry (ESI-MS) as a step toward the development of a µSYNTAS (miniaturized-SYNthesis and Total Analysis System).[2] The micromixer has been successfully used for the synthesis of small organic molecules via C-C and C-N bond-forming steps. The potential utility of this device for the production of compound libraries is demonstrated through a multicomponent reaction, thus illustrating a possible methodology for combinatorial synthesis.
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References
Bessoth, F.G.; deMello, A. J.; Manz, A.; “Microstructure for efficient continuous flow mixing.” Anal. Commun., 36, (1999), 213–215
Manz, A.; Graber, N.; Widmer, H. M.; “Miniaturized total chemical analysis systems: a nove concept for chemical sensing.” Sens. Actuators B, 1, (1990), 244–248.
Terrett, N. K.; “Combinatorial Chemistry”, Oxford University Press, Oxford, (1998).
Ugi, I.; Meyr, R.; Fetzer, C.; Steinbrückner, C.; “Versuche mit Isonitrilen.” Angew. Chem., 71, (1959), 386.
Harnby, N.; Edwards, M; Nienow, A.; “Mixing in the Process Industries”, Butterworth, Oxford, (1992).
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© 2000 Springer Science+Business Media Dordrecht
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Mitchell, M.C., Spikmans, V., Bessoth, F., Manz, A., de Mello, A. (2000). Towards Organic Synthesis in Microfluidic Devices: Multicomponent Reactions for the Construction of Compound Libraries. In: van den Berg, A., Olthuis, W., Bergveld, P. (eds) Micro Total Analysis Systems 2000. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-2264-3_108
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DOI: https://doi.org/10.1007/978-94-017-2264-3_108
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-5496-8
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