Skip to main content
SpringerLink
Log in

Evidence suggesting prostaglandins mediate lower oesophageal sphincter incompetence associated with inflammation

  • Chapter
Gastrointestinal Motility in Health and Disease

Abstract

At this meeting 2 years ago we showed that oesophagitis could be created in cats by infusing hydrochloric acid into the animal’s lower oesophagus. This oesophagitis markedly decreased the resting pressure of the lower oesophageal sphincter (normally abbreviated to LES). Furthermore the response of the inflamed LES to various pharmacological stimuli has been described1. This paper reports results of our attempts to prevent the oesophagitis with indomethacin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Higgs, R. H., Castell, D. O. and Eastwood, G. L. (1976). Studies on the mechanism of esophagitis-induced lower esophageal sphincter hypotension in cats. Gastroenterology, 71, 51

    PubMed  CAS  Google Scholar 

  2. Behar, J., Biancani, P. and Sheahan, D. (1976). Evaluation of esophageal tests in the diagnosis of reflux esophagitis. Gastroenterology, 71, 9

    PubMed  CAS  Google Scholar 

  3. Mulhopadhyeh, A., Rattan, S. and Goyal, R. (1975). Effect of prostaglandin Ez on esophageal motility in man. J. Appl. Physiol., 39, 479

    Google Scholar 

  4. Goyal, R. and Rattan, S. P. (1973). Mechanism of the lower esophageal sphincter relaxation. J. Clin. Invest., 52, 337

    Article  PubMed  CAS  Google Scholar 

  5. Ferreira, S. and Vane, J. (1974). New aspects of the mode of action of non-steroidal anti-inflammatory drugs. Ann. Rev. Pharmaeol., 14, 57

    Article  CAS  Google Scholar 

Download references

Authors
  1. F. Brown
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. Fletcher
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Castell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Eastwood
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Royal Infirmary, University Surgical Department, Sheffield, UK

    H. L. Duthie (Professor of Surgery) (Professor of Surgery)

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer Science+Business Media New York

About this chapter

Cite this chapter

Brown, F., Beck, B., Fletcher, R., Castell, D., Eastwood, G. (1978). Evidence suggesting prostaglandins mediate lower oesophageal sphincter incompetence associated with inflammation. In: Duthie, H.L. (eds) Gastrointestinal Motility in Health and Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-4389-1_68

Download citation

  • DOI: https://doi.org/10.1007/978-94-017-4389-1_68

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-017-4391-4

  • Online ISBN: 978-94-017-4389-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation