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Clinical Gene and Stem Cell Therapy in Patients with Acute and Chronic Myocardial Ischemia

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Adult and Pluripotent Stem Cells

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Abstract

The clinical consequence of the increasing incidence of coronary artery disease is a growing problem worldwide and ischemic heart disease remains the most common cause of death and a major cause of hospital admissions in industrialised countries. Early treatment with stabilizing drugs and mechanical revascularization by percutaneous coronary intervention or coronary by-pass surgery has reduced the mortality significantly. However, there is still a group of patients, which cannot be treated satisfactorily with these interventions. Treatment with genes encoding vascular growth factors or stem cells with the potential to regenerate the damaged myocardium is a relatively new approach. The results from early clinical studies on gene and stem cell therapy for cardiac regeneration in patients with acute or chronic ischemic heart disease have been inconsistent. Some of the discrepancy could be due to differences in study designs or patient selection. This review will present the conducted clinical trials and try to clarify the influence of patient selection, chosen cell type, cell source, delivery methods and mechanisms of action on the differences in results.

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Acknowledgements

This work was supported by a grant of the European Commission (Health-F2-2009-222995, INELPY/Infarct Cell Therapy)

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Authors and Affiliations

  1. Cardiology Stem Cell Centre and Cardiac Catheterization Laboratory 2014, The Hearth Centre, Rigshospitalet Copenhagen University Hospital and Faculty of Health Sciences, Blegdamsvej 9, 2100, Copenhagen, Denmark

    Jens Kastrup, Annette Ekblond, Mandana Haack-Sørensen, Anders B. Mathiasen & Abbas A. Qayyum

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  1. Jens Kastrup
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  2. Annette Ekblond
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  3. Mandana Haack-Sørensen
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  4. Anders B. Mathiasen
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  5. Abbas A. Qayyum
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Correspondence to Jens Kastrup .

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Editors and Affiliations

  1. University of Cologne, Germany

    Jürgen Hescheler

  2. Medical University of Vienna, Austria

    Erhard Hofer

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Kastrup, J., Ekblond, A., Haack-Sørensen, M., Mathiasen, A., Qayyum, A. (2014). Clinical Gene and Stem Cell Therapy in Patients with Acute and Chronic Myocardial Ischemia. In: Hescheler, J., Hofer, E. (eds) Adult and Pluripotent Stem Cells. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8657-7_8

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