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Multifunctional Protein-Based Nanoparticles for Cancer Theranosis

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Intracellular Delivery II

Part of the book series: Fundamental Biomedical Technologies ((FBMT,volume 7))

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Abstract

Selective delivery of therapeutic and/or diagnostic (theranostic) agents to diseased sites represents a major challenge to improve the outcome of current therapy and our ability to detect cancer cells at early stages or in the spread sites. A promising route to reach this goal is the design and engineering of functionalized nanoparticle (NP)-based carriers for targeted delivery of drug or diagnostic agents. Protein-based nanocarriers are attracting growing interest due to their exceptional characteristics, namely biodegradability, solubility, functionalization versatility and extraordinary binding capacity of various drugs. We highlight the use of these cage-shaped protein-based materials, with special emphasis on ferritin, as smart building blocks for the development of multifunctional NPs for cancer theranosis.

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Abbreviations

NP:

Nanoparticle

Hsp:

Heat shock proteins

Ft:

Ferritin

EPR:

Enhanced permeability and retention

mAbs:

Monoclonal antibodies

MRI:

Magnetic resonance imaging

Fe3O4 :

Magnetite

PEG:

Polyethylene glycol

CTP:

Carboxyl terminal peptide

VLP:

Viral-like particles

CPMV:

Cowpea mosaic virus

CCMV:

Cowpea Chlorotic Mottle Virus

sHsp:

Small heat shock proteins

Dps:

DNA-binding proteins from starved cells

HFt:

Human Ft

USPIO:

Ultrasmall Superparamagnetic Iron Oxide

TMB:

3,3′, 5,5′-Tetramethylbenzidine

DAB:

3,3′-Diaminobenzidine

PET:

Positron emission tomography

NIRF:

Near infrared fluorophores

MB:

Methylene blue

MFH:

Magnetic fluid hyperthermia

RGD:

Arginine-glycine-aspartate

α-MSH:

Α-melanocyte-stimulating hormone

EGF:

Epidermal growth factor

FcBP:

Fc-binding peptide

IgGs:

Immunoglobulins G

TfR1:

Transferrin receptor 1

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Acknowledgements

P.C. thanks the Italian Association for Cancer Research (AIRC), Milan (IT) for funding under grant agreement No. MFAG10545, and the Italian Ministry of Economy and Finance for funding the Project “FaReBio di Qualità”. L.V. acknowledges RVO 61388971 (CZ), Fondazione Anna Villa e Felice Rusconi Fund (IT), ENI Czech Republic s.r.o. (CZ), Manghi Czech Republic s.r.o. Fund (CZ), Paul’s Bohemia Trading s.r.o. (CZ) and Torino-Praga Invest s.r.o (CZ).

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  1. Institute of Microbiology, Academy of Sciences of the Czech Republic (ASCR), v.v.i, Prague, Czech Republic

    Luca Vannucci

  2. CNR—National Research Council of Italy, Institute of Molecular Biology and Pathology, Rome, Italy

    Elisabetta Falvo & Pierpaolo Ceci

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  1. Luca Vannucci
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  2. Elisabetta Falvo
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  3. Pierpaolo Ceci
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Correspondence to Luca Vannucci .

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  1. Chemical and Biological Engineering, Vanderbilt University, Nashville, Tennessee, USA

    Aleš Prokop

  2. Chemistry and Materials Engineering, Kansai University, Osaka, Japan

    Yasuhiko Iwasaki

  3. Department of Applied Chemistry, Osaka Prefecture University, Osaka, Japan

    Atsushi Harada

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Vannucci, L., Falvo, E., Ceci, P. (2014). Multifunctional Protein-Based Nanoparticles for Cancer Theranosis. In: Prokop, A., Iwasaki, Y., Harada, A. (eds) Intracellular Delivery II. Fundamental Biomedical Technologies, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-8896-0_12

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