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Protein-Protein Interactions: Structures and Druggability

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Multifaceted Roles of Crystallography in Modern Drug Discovery

Abstract

While protein-protein interfaces have promised a range of benefits over conventional sites in drug discovery, they present unique challenges. Here we describe recent developments that facilitate many aspects of the drug discovery process – including characterization and classification of interfaces, identifying druggable sites and strategies for inhibitor development.

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Authors and Affiliations

  1. Department of Biochemistry, Sanger Building, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK

    David B. Ascher, Harry C. Jubb, Douglas E. V. Pires, Takashi Ochi, Alicia Higueruelo & Tom L. Blundell

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  1. David B. Ascher
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  2. Harry C. Jubb
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  3. Douglas E. V. Pires
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  4. Takashi Ochi
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  5. Alicia Higueruelo
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  6. Tom L. Blundell
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Correspondence to Tom L. Blundell .

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  1. Structural Chemistry Department, Merck & Co, Inc., Kenilworth, New Jersey, USA

    Giovanna Scapin

  2. Center for Advanced Biotechnology and Medicine, and Rutgers University, Piscataway, New Jersey, USA

    Disha Patel

  3. Center for Advanced Biotechnology and Medicine, and Rutgers University, Piscataway, New Jersey, USA

    Eddy Arnold

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Ascher, D.B., Jubb, H.C., Pires, D.E.V., Ochi, T., Higueruelo, A., Blundell, T.L. (2015). Protein-Protein Interactions: Structures and Druggability. In: Scapin, G., Patel, D., Arnold, E. (eds) Multifaceted Roles of Crystallography in Modern Drug Discovery. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-9719-1_12

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