Abstract
WHO-CARDIAC (Cardiovascular Diseases and Alimentary Comparison) Study revealed the quintile analyses of 24-h urinary (24 U) taurine (T) and magnesium (Mg) excretions were inversely related with cardiometabolic risks (CMR) such as obesity, hypertension and hypercholesterolemia in 50 population samples in the world. To exclude the influence of ethnicity in the study, 24 U T and Mg excretions were analyzed for the association with CMR in one ethnicity, Japanese population.
24 U T/creatinine (C) ratios were divided into 5 quintiles and the ratios of Japanese to the total of each quintile were analyzed from CARDIAC Study samples. The highest 24 U T quintile consisted of 60% Japanese, indicating high seafood consumption in Japanese.
Over 600 Japanese aged 30–79 were invited to a health examination for blood pressure measurement and for fasting blood and 24 U samplings. Tertile analysis of 24 U T/C ratios in relation to CMR indicated the third tertile had significantly higher HDL cholesterol, 24 U potassium (K) and 24 U salt than the first (lowest) tertile. Tertile analysis of 24 U Mg/C ratios indicated the third tertile had significantly lower body mass index and significantly higher folic acid, 24 U isoflavones, K and salt than the first tertile after age and gender adjustment. The third tertile of both T/C and Mg/C had significantly lower body mass index, LDL/HDL and Na/K ratios, and significantly higher HDL cholesterol and folic acid than the first tertile, indicating seafood eaters taking Mg rich diets had lower risks of obesity, atherosclerosis, hypertension and higher folic acid, beneficial for healthy longevity.
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Abbreviations
- 24 U:
-
24-hour urine
- BP:
-
Blood pressure
- C:
-
Creatinine
- CMR:
-
Cardiometabolic risks
- HDL:
-
High density lipoprotein
- HOMA-IR:
-
Homeostasis model of assessment of insulin resistance
- K:
-
Potassium
- Mg:
-
Magnesium
- T:
-
Taurine
- WHO:
-
World Health Organization
References
Abbott RD, Wilson PWF, Kannel WB, Castelli WP (1988) High density lipoprotein cholesterol, total cholesterol screening, and myocardial infarction. The Framingham Study. Arteriosclerosis 8:207–211
Cui R, Iso H, Date C, Kikuchi S, Tamakoshi A (2010) Dietary folate and vitamin B6 and B12 intake in relation to mortality from cardiovascular diseases: Japan Collaborative Cohort Study. Stroke 4:1285–1289
Eoin P, Quinlivan EP, Gregory JF (2003) Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 77:221–225
Haynes WG (2002) Hyperhomocysteinemia vascular function and atherosclerosis: effects of vitamins. Cardiovasc Drug Ther 16:391–399
Joosten MM, Gansevoort RT, Mukamal KJ, Kootstraros JE, EJM F, Geleijnse JM, Navis G, SJL B (2013) Urinary magnesium excretion and risk of hypertension: the prevention of renal and vascular end-stage disease study. Hypertension 61:1161–1167
Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm EB, Danaei G, The Global Burden of Metabolic Risk Factors for Chronic Disease Collaboration (2014) Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. Lancet 383:970–983
Millán J, Pintó X, Muñoz A, Zúñiga M, Rubiés-Prat J, Pallardo LF, Masana L, Mangas A, Hernández-Mijares A, González-Santos P, Ascaso JF, Pedro-Botet J (2009) Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag 5:757–765
Omoni AO, Aluko RE (2005) Soybean foods and their benefits: potential mechanisms of action. Nutr Rev 63:272–283
Perez V, Chang E (2014) Sodium-to-potassium ratio and blood pressure, hypertension, and related factors. Adv Nutr 5:712–741
Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M (2006) Soy protein, isoflavones, and cardiovascular health. Circulation 113:1034–1044
Sagara M, Murakami S, Mizushima S, Liu L, Mori M, Ikeda K, Nara Y, Yamori Y (2015) Taurine in 24-h urine samples is inversely related to cardiovascular risks of middle aged subjects in 50 populations of the world. Adv Exp Med Biol 803:623–636
Strom BL, Yaktine AL, Oria M (2013) Sodium intake in populations: assessment of evidence. Committee on the Consequences of Sodium Reduction in Populations; Food and Nutrition Board; Board on Population Health and Public Health Practice; Institute of Medicine National Academies Press
Yamori Y (2006a) Soy for “Health for All”: message from WHO CARDIAC Study and dietary intervention studies. In: Sugano M (ed) Soy in health and disease prevention. Taylor & Francis, Florida, pp 107–121
Yamori Y (2006b) Food factors for atherosclerosis prevention: Asian perspective derived from analyses of world-wide dietary biomarkers. Exp Clin Cardiol 11:94–98
Yamori Y (2008) Nutrition for healthier ageing—two decades of world-wide surveys on diet and human life. In: Proceedings of the international symposium: food culture: development and education for longivity, 20-year CARDIAC Study symposium supported by UNESCO. Paris 2005: Nonprofit Organization World Health Frontier Institute, pp 23–41
Yamori Y, Nara Y, Kihara M, Mano M, Horie R (1984) Simple method for sampling consecutive 24-hour urine for epidemiological and clinical studies. Clin Exp Hypertens A 6:1161–1167
Yamori Y, Nara Y, Ikeda K, Mizushima S (1996) Is taurine a preventive nutritional factor of cardiovascular diseases or just a biological marker of nutrition? Adv Exp Med Biol 403:623–629
Yamori Y, Liu L, Ikeda K, Miura A, Mizushima S, Miki T, Nara Y (2001a) Distribution of twenty-four hour urinary taurine excretion and association with ischemic heart disease mortality in 24 populations of 16 countries: results from the WHO-CARDIAC study. Hypertens Res 24:453–457
Yamori Y, Miura A, Taira K (2001b) Implications from and for food cultures for cardiovascular diseases: Japanese food, particularly Okinawan diets. Asia Pac J Clin Nutr 10:144–145
Yamori Y, Liu L, Mizushima S, Ikeda K, Nara Y, CARDIAC Study Group (2006) Male cardiovascular mortality and dietary markers in 25 population samples of 16 countries. J Hypertens 24:1499–1505
Yamori Y, Liu L, Mori M, Sagara M, Murakami S, Nara Y, Mizushima S (2009) Taurine as the nutritional factor for the longevity of the Japanese revealed by a world-wide epidemiological survey. Adv Exp Med Biol 643:13–25
Yamori Y, Taguchi T, Hamada A, Kunimasa K, Mori H, Mori M (2010a) Taurine in health and diseases: consistent evidence from experimental and epidemiological studies. J Biomed Sci 17(Suppl 1):S6
Yamori Y, Taguchi T, Mori H, Mori M (2010b) Low cardiovascular risks in the middle aged males and females excreting greater 24-hour urinary taurine and magnesium in 41 WHO-CARDIAC study populations in the world. J Biomed Sci 17(Suppl 1):S21
Yamori Y, Sagara M, Mizushima S, Liu L, Ikeda K, Nara Y (2015) An inverse association between magnesium in 24-h urine and cardiovascular risk factors in middle-aged subjects in 50 CARDIAC Study populations. Hypertens Res 38:219
Acknowledgements
We express our appreciation to all participants in WHO-CARDIAC Study as well as in the health examination by Hyogo Prefecture Health Promotion Association (HPHPA). This work was supported by JSPS KAKENHI Grant Number A 20256001 and by HPHPA.
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Yamori, Y. et al. (2017). Taurine Intake with Magnesium Reduces Cardiometabolic Risks. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_80
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DOI: https://doi.org/10.1007/978-94-024-1079-2_80
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