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Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells

  • Conference paper
Taurine 10

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 975))

Abstract

Prostate cancer is the most common non-cutaneous cancers among men and the second leading cause of cancer-related deaths among men. Aberrant activation of the epithelial to mesenchymal transition (EMT) has been exhibited to be one of the most common causes of treatment failure and death in cancer patients. In cancer cells with metastatic competence, the E-cadherin switch is a well-established hallmark. Suppression of E-cadherin through its transcriptional repressor SNAIL is thus a determining factor for EMT. TWIST1 is an important transcription factor in EMT, which is present under both physiologic (embryogenesis) and pathologic (metastasis) conditions, and enhances the invasiveness and migration ability of cells. In this study, we investigated the inhibitory effects of taurine on EMT-related genes, such as E-cadherin, N-cadherin, TWIST1, ZEB1, SNAIL, and vimentin. EMT markers were detected by RT-PCR and western blotting. The results showed that taurine down-regulated the expression of N-cadherin, TWIST1, ZEB1, SNAIL, and vimentin. In contrast, taurine increased E-cadherin expression. Our findings indicate that taurine has EMT inhibitory effects on human prostate cancer cells.

$These authors contributed equally to this work.

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Abbreviations

EMT:

Epithelial to mesenchymal transition

PSA:

Prostate-specific antigen

SNAIL:

Snail family zinc finger 1

TWIST1:

Basic helix-loop-helix protein 38

ZEB1:

Zinc finger E-box binding homeobox 1

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Acknowledgments

This research was supported by the Basic Science Research Program through the National Research Foundation of South Korea (NRF) funded by the Ministry of Education, Science and Technology (2013R1A1A3006958), and Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through the Agri-Bio industry Technology Development Program (316027-5) funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA).

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    Authors and Affiliations

    1. Division of Food Bioscience, Konkuk University, Chungju, South Korea

      Yujiao Tang, Yeong Sik Yun & Eun-Kyung Kim

    2. Division Korea Nokyong Research Center, Konkuk University, Chungju, South Korea

      Yujiao Tang, Pyo-Jam Park & Eun-Kyung Kim

    3. Department of Biotechnology, Konkuk University, Chungju, South Korea

      Yon-Suk Kim & Pyo-Jam Park

    4. Division of Sport Science, Konkuk University, Chungju, South Korea

      Eun-Ju Choi

    5. Department of Food Science and Culinary, International University of Korea, Jinju, South Korea

      Young Joung Hwang

    6. Gyeongnam Agricultural Research and Extension Services, Gyeongnam, South Korea

      Sung Mun Bae

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    1. Yujiao Tang
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    Correspondence to Eun-Kyung Kim .

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    Editors and Affiliations

    1. Department of Life Sciences, University of Seoul, Seoul, South Korea

      Dong-Hee Lee  & Ha Won Kim  & 

    2. College of Medicine, University of South Alabama, Mobile, Alabama, USA

      Stephen W. Schaffer

    3. Department of Developmental Neurobiology, NY State Institute for Basic Research in Developmental Disabilities, New York, USA

      Eunkyue Park

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    Tang, Y. et al. (2017). Taurine Attenuates Epithelial-Mesenchymal Transition-Related Genes in Human Prostate Cancer Cells. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_96

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