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Efficacy of Hyperthermia in Combination with Radiation Therapy for Breast Cancer

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Hyperthermic Oncology from Bench to Bedside

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Abstract

Hyperthermia continues to show clinical benefits in randomized trials across a spectrum of malignancies, with generally well-tolerated side effects when administered as multimodality therapy. Hyperthermia contributes to direct tumor cell killing, and may also enhance the antitumor effects of chemotherapy and radiation therapy. Particularly, hyperthermia has been shown to be beneficial for treating superficial malignancies, such as chest wall recurrence of breast cancer. Although much evidence has been gained from clinical trials and studies of hyperthermia, regular use has not yet been established for breast cancer treatment. In this review article, we will highlight the benefits of therapeutic hyperthermia and the combined use of hyperthermia and radiation, and overview the results reported from clinical trials.

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Conflict of Interest

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Authors and Affiliations

  1. Department of Surgery, Kansai Medical University, Takii, Osaka, Japan

    Daigo Yamamoto

  2. Department of Internal Medicine, Seiko Hospital, Osaka, Japan

    Daigo Yamamoto & Chizuko Yamamoto

  3. Department of Palliative Medicine, Institute of Medical Science, University of Tokyo Hospital, Tokyo, Japan

    Satoru Iwase

  4. Department of Surgery, Hirosaki National Hospital, Hirosaki, Japan

    Hiroki Odagiri

Authors
  1. Daigo Yamamoto
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  2. Chizuko Yamamoto
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  3. Satoru Iwase
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  4. Hiroki Odagiri
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Corresponding author

Correspondence to Daigo Yamamoto .

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Editors and Affiliations

  1. Kokura Lab, Health and Medical Sciences, Kyoto Gakuen University, Kyoto, Kyoto, Japan

    Satoshi Kokura

  2. Department of Inflammation and Immunolog, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan

    Toshikazu Yoshikawa

  3. Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan

    Takeo Ohnishi

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Yamamoto, D., Yamamoto, C., Iwase, S., Odagiri, H. (2016). Efficacy of Hyperthermia in Combination with Radiation Therapy for Breast Cancer. In: Kokura, S., Yoshikawa, T., Ohnishi, T. (eds) Hyperthermic Oncology from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-10-0719-4_18

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  • DOI: https://doi.org/10.1007/978-981-10-0719-4_18

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