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Pathology of Preinvasive Lesions of the Cervix

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Colposcopy of Female Genital Tract

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Abstract

Preinvasive intraepithelial lesions contain a group of proliferative lesions characterized by abnormal cytological and histological differentiation, maturation, and stratification of squamous or columnar epithelium. Microscopically they are characterized by nuclear atypia, increased mitotic activity, and the presence of atypical mitoses and cellular pleomorphism on all epithelium levels, regardless of the degree of cytoplasm maturation [1]. The intensity of these lesions varies in accordance with the extent of epithelial involvement. Since these lesions have a potential to develop into invasive carcinoma, pathological diagnosis plays a very important role in the management of these conditions. The fear of missing an invasive carcinoma leads to a tendency of overdiagnosis by the pathologist and overtreatment by the clinician. Hence, understanding the basic pathology and the use of correct terminology and standard management guidelines are the need of the hour. A good knowledge of the etiology, pathophysiology, and natural history of cervical intraepithelial neoplasia (CIN) provides a strong basis both for visual testing and for colposcopic diagnosis and understanding the principles of treatment of these lesions. This chapter describes the evolution of the classification systems of cervical squamous cell cancer precursors and the cytological and histological basis of their diagnosis.

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Authors and Affiliations

  1. Fellowship Gyne Oncology and , Diploma Advanced Gyne Endoscopy, Consultant Gyne Oncologist, Dharamshila Hospital and Research Centre, Delhi, India

    Satinder Kaur MD, DNB

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  1. Satinder Kaur MD, DNB
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Correspondence to Satinder Kaur MD, DNB .

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Editors and Affiliations

  1. Babu Jagjivan Ram Memorial Hospital, Dept of Obstetrics & Gynecology Babu Jagjivan Ram Memorial Hospital, New Delhi, India

    Sumita Mehta

  2. Maulana Azad Med. College&Lok Nayak Hos., Dept. of Obstetrics & Gynecology Maulana Azad Med. College&Lok Nayak Hos., New Delhi, India

    Poonam Sachdeva

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Kaur, S. (2017). Pathology of Preinvasive Lesions of the Cervix. In: Mehta, S., Sachdeva, P. (eds) Colposcopy of Female Genital Tract. Springer, Singapore. https://doi.org/10.1007/978-981-10-1705-6_2

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  • DOI: https://doi.org/10.1007/978-981-10-1705-6_2

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-10-1704-9

  • Online ISBN: 978-981-10-1705-6

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