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The Emerging Roles of RUNX Transcription Factors in Epithelial-Mesenchymal Transition

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RUNX Proteins in Development and Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 962))

Abstract

Epithelial-mesenchymal transition (EMT) is an evolutionary conserved morphogenetic program necessary for the shaping of the body plan during development. It is guided precisely by growth factor signaling and a dedicated network of specialised transcription factors. These are supported by other transcription factor families serving auxiliary functions during EMT, beyond their general roles as effectors of major signaling pathways. EMT transiently induces in epithelial cells mesenchymal properties, such as the loss of cell-cell adhesion and a gain in cell motility. Together, these newly acquired properties enable their migration to distant sites where they eventually give rise to adult epithelia. However, it is now recognized that EMT contributes to the pathogenesis of several human diseases, notably in tissue fibrosis and cancer metastasis. The RUNX family of transcription factors are important players in cell fate determination during development, where their spatio-temporal expression often overlaps with the occurrence of EMT. Furthermore, the dysregulation of RUNX expression and functions are increasingly linked to the aberrant induction of EMT in cancer. The present chapter reviews the current knowledge of this emerging field and the common themes of RUNX involvement during EMT, with the intention of fostering future research.

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Acknowledgement

The authors thank Rebecca Jackson for her generous help in the preparation of the manuscript. We are also grateful to Jormay Lim and Isao Kobayashi for their valuable input.

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Authors and Affiliations

  1. Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan

    Dominic Chih-Cheng Voon

  2. Division of Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan

    Dominic Chih-Cheng Voon

  3. Cancer Science Institute of Singapore, National University of Singapore, Singapore, 117599, Singapore

    Jean Paul Thiery

  4. Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117596, Singapore

    Jean Paul Thiery

  5. Institute of Molecular and Cell Biology, A-STAR, Singapore, 138673, Singapore

    Jean Paul Thiery

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  1. Dominic Chih-Cheng Voon
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Correspondence to Dominic Chih-Cheng Voon .

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Editors and Affiliations

  1. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel

    Yoram Groner

  2. Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

    Yoshiaki Ito

  3. Genetics and Molecular Biology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA

    Paul Liu

  4. Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    James C. Neil

  5. Department of Cell and Development Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Nancy A. Speck

  6. Mayo Clinic, Rochester, Minnesota, USA

    Andre van Wijnen

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Voon, D.CC., Thiery, J.P. (2017). The Emerging Roles of RUNX Transcription Factors in Epithelial-Mesenchymal Transition. In: Groner, Y., Ito, Y., Liu, P., Neil, J., Speck, N., van Wijnen, A. (eds) RUNX Proteins in Development and Cancer. Advances in Experimental Medicine and Biology, vol 962. Springer, Singapore. https://doi.org/10.1007/978-981-10-3233-2_28

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