Abstract
The biological surface adsorption index approach (BSAI) presents a novel approach for characterization of nanoparticles (NPs) in biological sys-tems. It is used for identification and quantitation of intermolecular forces that govern the adsorption properties of biomolecules on NPs surface. BSAI presents very important step in characterization of NPs-biomolecules interactions. Knowledge about the mechanism of interactions could help in prediction of NPs eventual toxicity in biological systems.
Gold NPs are very often used in medicine, cosmetics and pharmacy thus evaluation of potential toxicity of gold NPs is extremely important prior its ap-plication.
In this paper BSAI approach was applied on gold NPs with three different size (5 nm, 15 nm and 30 nm). The results showed that interactions of gold NPs and biomolecules vary in dependence of the size of NPs.
The results contribute in toxicity assessment of gold nanoparticles in combi-nation with other analytical tools for toxicity assessment.
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References
Xia, X.R, Monteiro-Riviere, N.A., Riviere, J.E. (2010) An index for characterization of nanomaterials in biological systems. Nat Nanotechnol , 5, 671–675
Omanovic-Miklicanin, E., Valzacchi, S., Simoneau, C., Gilliland, D., Rossi, F., (2014) Solid-phase microextraction/gas chromatography–mass spectrometry method optimization for characterization of surface adsorption forces of nanoparticles, Analytical and Bioana-lytical Chemistry, 406 (26), 6629-6636
Xia, X.R., Monteiro-Riviere, N.A., Mathur, S., Song, X., Xiao, L., Oldenberg, S.J., Fadeel, B., Riviere, J.E. (2011) Mapping the surface adsorption forces of nanomaterials in biological systems using the biological surface adsorption index (BSAI) approach. ACS Nano, 5(11), 9074-9081
Parveen, R., Shamsi, T.N., Sadaf, F., (2017) Nanoparticles-Protein Interaction: Role in Protein Aggregation and Clinical Implications, International Journal of Biological Macro-molecules, A 94, 386-395
Ujfalussy, I., Koo, E., Sesztak, M., Gergely, P. (2003) Termination of disease-modifying antirheumatic drugs in rheumatoid arthritis and in psoriatic arthritis. A compar-ative study of 270 cases. Z Rheumatol, 62(2), 155–160
Joshi, H., Shirude, P.S., Bansal, V., Ganesh, K.N., Sastry, M., (2004) Isothermal Titration Calorimetry Studies on the Binding of Amino Acids to Gold Nanoparticles, J. Phys. Chem. B, 108 (31), 11535–11540
Omanovic-Miklicanin, E., Manfeld, I., Wilkins, T., (2016) Application of isothermal titration calorimetry in evaluation of nanoparticle-protein interactions, doi: 10.1007/s10973-016-5764-4
Zeng, S., Baillargeat, D., Ho-Pui, H.; Ken-Tye H. (2014). “Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications”. Chemical Society Reviews. 43 (10), 3426–3452.
Berne, B.J.; Pecora, R. (2000) Dynamic Light Scattering. Courier Dover Publications (2000) ISBN 0-486-41155-9
Turkevich J, Stevenson PC, Hillier J (1951) A study of the nucleation and growth pro-cesses in the synthesis of colloidal gold. Discuss Faraday Soc 11, 55–75
Turkevich J, Stevenson PC, Hillier J (1953) The formation of colloidal gold. J Phys Chem 57, 670–673
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Omanović-Mikličanin, E., Husremović, T., Jakupović, A., Omerbašić, A. (2017). Application of biological surface adsorption index approach (BSAI) in characterization of interactions between gold nanoparticles and biomolecules. In: Badnjevic, A. (eds) CMBEBIH 2017. IFMBE Proceedings, vol 62. Springer, Singapore. https://doi.org/10.1007/978-981-10-4166-2_28
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DOI: https://doi.org/10.1007/978-981-10-4166-2_28
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