Abstract
Development of protein-based molecular devices is an active area of research due to their broad applications in biotechnology, biorelated chemistry, bioelectronics, and biomedical engineering. Hemoglobin (Hb) is a physiologically important oxygen-transport metalloprotein present in the red blood cells. In this chapter, we present the recent development in fabrication and tailoring of a variety of hemoglobin protein shells via covalent layer-by-layer (LbL) assembly combined with template technique. Also, the developed strategy is effective and flexible, advantageous for avoiding denaturation of proteins. The as-fabricated Hb shells have better applications in drug delivery and controlled release, biosensors, biocatalysis, and bioreactors due to the enhancement of biological availability. In view of the carrying-oxygen function of Hb protein in blood, we particularly focus on the potential applications of hemoglobin-based nanoarchitectonic assemblies as artificial blood substitutes. These novel oxygen carriers exhibit advantages over traditional carriers and will greatly promote research on reliable and feasible artificial blood substitutes.
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Duan, L., Jia, Y., Li, J. (2017). Hemoglobin-Based Molecular Assembly . In: Li, J. (eds) Supramolecular Chemistry of Biomimetic Systems. Springer, Singapore. https://doi.org/10.1007/978-981-10-6059-5_5
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DOI: https://doi.org/10.1007/978-981-10-6059-5_5
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