Abstract
The mangroves represent one of the most productive ecosystems located in the transition zone between land and sea characterized by periodic flooding and high salinity that confers unique environmental conditions to this biome. This ecosystem is dominated particularly by mangrove plant species that provide a unique environment harbouring diverse groups of microorganisms, including the endophytic microorganisms. The mangrove plants are known for their unique and diverse metabolites and because of their intimate association with mangrove plants, the mangrove derived endophytic microorganisms are explored for structurally unprecedented bioactive natural products. Mangrove endophytes represent a rich source of bioactive metabolites and are promising source of novel constituents. A systematic investigation of their metabolites may lead to the discovery of novel bioactive agents with useful medicinal and pharmaceutical applications. Therefore, in this review article an attempt has been made to summarize the different metabolites derived from the mangrove endophytes along with their potential pharmacological role for possible pharmaceutical exploitations.
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References
Andrew JH, Hirano SS (1991) Microbial ecology of leaves. Brock, London
Arnold AE, Maynard Z, Gilbert GS (2001) Fungal endophytes in dicotyledonous neotropical trees: patterns of abundance and diversity. Mycol Res 105:1502–1507
Baltruschat H, Fodor J, Harrach BD, Niemczyk E, Barna B, Gullner G, Janeczko A, Kogel KH, Schäfer P, Schwarczinger I, Zuccaro A (2008) Salt tolerance of barley induced by the root endophyte Piriformospora indica is associated with a strong increase in antioxidants. New Phytol 180:501–510
Bharathidasan R, Panneerselvam A (2012) Antioxidant activity of the endophytic fungi isolated from mangrove environment of Karankadu, Ramanathapuram district. Int J Pharm Sci Res 3:2866–2869
Bhimba BV, Franco DAAD, Jose GM, Mathew JM, Joel EL (2011) Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4. Asian Pac J Trop Biomed 1:223–226
Bin G, Yanping C, Hong Z, Zheng X, Yanqiu Z, Huaiyi F, Qiupin Z, Chenxiao Z (2014) Isolation, characterization and anti-multiple drug resistant (MDR) bacterial activity of endophytic fungi isolated from the mangrove plant, Aegiceras corniculatum. Trop J Pharm Res 13:593–599
Calcul L, Waterman C, Ma WS, Lebar MD, Harter C, Mutka T, Morton L, Maignan P, Van Olphen A, Kyle DE, Vrijmoed L, Pang KL, Pearce C, Baker BJ (2013) Screening mangrove endophytic fungi for antimalarial natural products. Mar Drugs 11:5036–5050
Chaeprasert S, Piapukiew, Whalley AJS, Sihanonth P (2010) Endophytic fungi from mangrove plant species of Thailand: their antimicrobial and anticancer potentials. Bot Mar 53:555–564
Chen YL, Mao WJ, Tao HW, Zhu WM, Yan MX, Liu X, Guo TT, Guo T (2015) Preparation and characterization of a novel extracellular polysaccharide with antioxidant activity, from the mangrove-associated fungus Fusarium oxysporum. Mar Biotechnol 16:219–228
Chokpaiboon S, Sommit D, Teerawatananond T, Muangsin N, Bunyapaiboonsri T, Pudhom K (2010) Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomyce- tous fungus. J Nat Prod 73:1005–1007
Christophersen C, Crescente O, Frisvad JC, Gram L, Nielsen J, Nielsen PH, Rahbaek L (1998) Antibacterial activity of marine derived fungi. Mycopathologia 143:135–138
Ding L, Munch J, Goerls H, Maier A, Fiebig HH, Lin WH, Hertweck C (2010) Xiamycin, a pentacyclic indolosesquiterpene with selective anti-HIV activity from a bacterial mangrove endophyte. Bioorg Med Chem Lett 20:6685–6687
Ding L, Maier A, Fiebig HH, Lin WH, Hertweck C (2011) A family of multicyclic indolosesquiterpenes from a bacterial endophyte. Org Biomol Chem 9:4029–4031
Ebrahim W, Kjer J, El Amrani M, Wray V, Lin W, Ebel R, Lai D, Proksch P (2012) Pullularins E and F, two new peptides from the endophytic fungus Bionectria ochroleuca isolated from the mangrove plant Sonneratia caseolaris. Mar Drugs 10:1081–1091
Elavarasi A, Sathiya Rathna G, Kalaiselvam M (2012) Taxol producing mangrove endophytic fungi Fusarium oxysporum from Rhizophora annamalayana. Asian Pac J Trop Biomed:S1081–S1085
Elavarasi A, Peninal S, Rathna GS, Kalaiselvam M (2014) Studies on antimicrobial compounds isolated from mangrove endophytic fungi. World J Pharm Pharm Sci 3:734–744
Eldeen IMS (2014) Isolation of 12 bacterial endophytes from some mangrove plants and determination of, antimicrobial properties of the isolates and the plant extracts. Int J Phytomed 6:425–433
Fisher PJ, Petrini O, Scott HL (1992) The distribution of some fungal and bacterial endophytes in maize (Zea mays L.) New Phytol 122:299–305
Freeman EM (1904) The seed-fungus of Lolium temulentum, L., the Darnel. Philos Trans R Soc Lond B Containing Pap Biol Charact 196:1–27
Frohlich J, Hyde KD, Petrini O (2000) Endophytic fungi associated with palms. Mycol Res 104:1202–1203
Huang J, Li Q, Sun D, Lu Y, Su Y, Yang X, Wang H, Wang Y, Shao W, He N, Hong J (2007) Biosynthesis of silver and gold nanoparticles by novel sundried Cinnamomum camphora leaf. Nanotechnology 18:105104
Huang Z, Cai X, Shao C, She Z, Xia X, Chen Y, Yang J, Zhou S, Lin Y (2008) Chemistry and weak antimicrobial activities of phomopsins produced by mangrove endophytic fungus Phomopsis sp. ZSU-H76. Phytochemistry 69:1604–1608
Huang Z, Guo Z, Yang R, Yin X, Li X, Luo W, She Z, Lin Y (2009) Chemistry and cytotoxic activities of polyketides produced by the mangrove endophytic fungus Phomopsis sp. ZSU-H76. Chem Nat Compd 45:625–628
Huang HB, Feng XJ, Liu L, Chen B, Lu YJ, Ma L, She ZG, Lin YC (2010) Three dimeric naphtho-g-pyrones from the mangrove endophytic fungus Aspergillus tubingensis isolated from Pongamia pinnata. Planta Med 76:1888–1891
Huang H, Feng X, Xiao ZE, Liu L, Li H, Ma L, Lu Y, Ju J, She Z, Lin Y (2011a) Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea. J Nat Prod 74:997–1002
Huang CH, Pan JH, Chen B, Yu M, Huang HB, Zhu X, Lu YJ, She ZG, Lin YC (2011b) Three bianthraquinone derivatives from the mangrove endophytic fungus Alternaria sp. ZJ9–6B from the South China Sea. Mar Drugs 9:832–843
Huang Z, Yang SZ, Lin Y (2012) A new isoflavone from the mangrove endophytic fungus Fusarium sp. (ZZF60). Nat Prod Res 26:11–15
Jiny VK, Belzik N, Nisha AR, Resiya S, Resmi S, Silvipriya KS (2010) Pharmacognostical and phytochemical studies of a mangrove (Sonneratia caseolaris) from Kochi of Kerala state in India. J Pharm Res 3:2625–2627
Job N, Manomi S, Philip R (2015) Isolation and characterisation of endophytic fungi from Avicennia officinalis. Int J Res Biomed Biotechnol 5:4–8
Joel EL, Bhimba BV (2012) Fungi from mangrove plants: their antimicrobial and anticancer potentials. Int J Pharm Pharm Sci 3:139–142
Jose AC, Christy PH (2013) Assessment of antimicrobial potential of endophytic bacteria isolated from Rhizophora mucronata. Int J Curr Microbiol App Sci 2:188–194
Kandasamy S, Kandasamy K (2014) Antioxidant activity of the mangrove endophytic fungus (Trichoderma sp.) J Coast Life Med 2:566–570
Khrueayu D, Pilantanapak A (2012) Antifungal activity of bioactive compound from endophytic fungi isolated from mangrove leaves. In: 1st Mae Fah Luang University international conference
Kjer J (2009) New natural products from endophytic fungi from mangrove plants– structure elucidation and biological screening. PhD thesis, Faculty of Mathematics and Natural Sciences, Heinrich Heine University, Dusseldorf
Klaiklay S, Rukachaisirikul V, Tadpetch K, Sukpondma Y, Phongpaichit S, Buatong J, Sakayaroj J (2012) Chlorinated chromone and diphenyl ether derivatives from the mangrove-derived fungus Pestalotiopsis sp. PSU-MA69. Tetrahedron 68:2299–2305
Li DL, Li XM, Li TG, Dang HY, Proksch P, Wang BG (2008) Benzaldehyde derivatives from Eurotium rubrum, an endophytic fungus derived from the mangrove plant Hibiscus tiliaceus. Chem Pharm Bull 56:1282–1285
Li KK, Lu YJ, Song XH, She ZG, Wuc XW, An LK, Ye CX, Lin YC (2010) The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea. Bioorg Med Chem Lett 20:3326–3328
Li H, Huang H, Shao C, Huang H, Jiang J, Zhu X, Liu Y, Liu, Lu Y, Li M, Lin Y, She Z (2011) Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala. J Nat Prod 74:1230–1235
Li S, Wei M, Chen G, Lin Y (2012) Two new dihydroisocoumarins from the endophytic fungus Aspergillus sp. collected from the South China Sea. Chem Nat Compd 48:371–373
Li D, Yan S, Proksch P, Liang Z, Li Q, Xu J (2013) Volatile metabolites profiling of a Chinese mangrove endophytic Pestalotiopsis sp. strain. Afr J Biotechnol 12:3802–3806
Lin W, Li L, Fu H, Sattler I, Huang X, Grabley S (2005) New cyclopentenone derivatives from an endophytic Streptomyces sp. isolated from the mangrove plant Aegiceras comiculatum. J Antibiot 58:594
Lin Z, Zhu T, Fang Y, Gu Q, Zhu W (2008) Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum. Phytochemistry 69:1273–1278
Lin Z, Zhang GJ, Zhu TJ, Liu R, Wei HJ, Gu Q (2009) Bioactive cytochalasins from Aspergillus flavipes, an endophytic fungus associated with the mangrove plant Acanthus ilicifolius. Helv Chim Acta 92:1538–1544
Ling OM, Teen LP, Mujahid A, Proksch P, Muller M (2016) Initial screening of mangrove endophytic fungi for antimicrobial compounds and heavy metal biosorption potential. Sains Malays 45:1063–1071
Liu F, Cai XL, Yang H, Xia XK, Guo ZY, Yuan J, Li MF, She ZG, Lin YC (2010) The bioactive metabolites of the mangrove endophytic fungus Talaromyces sp. ZH-154 isolated from Kandelia candel (L.) Planta Med 76:185–189
Liu D, Li XM, Meng L, Li CS, Gao SS, Shang Z, Proksch P, Huang CG, Wang BG (2011) Nigerapyrones A-H, α-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132. J Nat Prod 74:1687–1691
Liu Y, Xia G, Li H, Ma L, Ding B, Lu Y (2014) Vermistatin derivatives with α-glucosidase inhibitory activity from the mangrove endophytic fungus Penicillium sp. HN29-3B1. Planta Med 80:912–916
Lu Z, Zhu H, Fu P, Wang Y, Zhang Z, Lin H, Liu P, Zhuang Y, Hong K, Zhu W (2010) Cytotoxic polyphenols from the marine-derived fungus Penicillium expansum. J Nat Prod 73:911–914
Maria GL, Sridhar KR, Raviraja NS (2005) Antimicrobial and enzyme activity of mangrove endophytic fungi of South west coast of India. J Agric Tech 1:67–80
Mcinroy JA, Kloepper JW (1995) Survey of indigenous bacterial endophytes from cotton and sweet corn. Plant Soil 163:337–342
Mei WL, Zheng B, Zhao YX, Zhong HM, Chen XL, Zeng YB, Dong WH, Huang JL, Proksch P, Dai HF (2012) Meroterpenes from endophytic fungus A1 of mangrove plant Scyphiphora hydrophyllacea. Mar Drugs 10:1993–2001
Molina G, Pimentel MR, Bertucci TCP, Pastore GM (2012) Application of fungal endophytes in biotechnological processes. Chem Eng Trans 27:289–294
Norhayati A, Shukor MN, Juliana S, Wan Juliana WA (2009) Mangrove flora and fauna of Klang islands mangrove forest reserves, Selangor, Malaysia. Malays J Sci 28:275–288
Ravindran C, Naveenan T, Varatharajan GR, Rajasabapathy R, Meena RM (2012) Antioxidants in mangrove plants and endophytic fungal associations. Bot Mar 55:269–279
Redman RS, Sheehan KB, Stout RG, Rodriguez RJ, Henson JM (2002) Thermotolerance generated by plant/fungal symbiosis. Science 298:1581
Rukachaisirikul V, Rodglin A, Sukpondma Y, Phongpaichit S, Buatong J, Sakayaroj J (2012) Phthalide and isocoumarin derivatives produced by an Acremonium sp. isolated from a mangrove Rhizophora apiculata. J Nat Prod 75:853–858
Saad S, Taher M, Susanti D, Qaralleh H, Awang AF (2012) In vitro antimicrobial activity of mangrove plant Sonneratia alba. Asian P J Trp Bio 2:427–429
Salini G, Madhusoodhanan A, Joseph A, Mohan A, Navya RK, Nair VV (2015) Antibacterial and antioxidant potential of endophytic fungi isolated from mangroves. Der Pharmacia Lett 7:53–57
Shao SL, Wang CY, Gu YC, Wei MY, Pan JH, Deng DS, She ZG, Lin YC (2010) Penicinoline, a new pyrrolyl 4-quinolinone alkaloid with an unprecedented ring system from an endophytic fungus Penicillium sp. Bioorg Med Chem Lett 20:3284–3286
Singh SB, Zink DL, Polishook JD, Dombrowski AW, Darkin-Rattray SJ, Schmatz DM, Goetz MA (1996) Apicidins: novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum. Tetrahedron Lett 37:8077–8080
Singh R, Sharma M, Joshi P, Rawat DS (2008) Clinical status of anti-cancer agents derived from marine sources. Anti Cancer Agents Med Chem 8:603–616
Sona Janarthine SR, Eganathan P, Balasubramanian T, Vijayalakshmi S (2011) Endophytic bacteria isolated from the pneumatophores of Avicennia marina. Afr J Microbiol Res 5:4455–4466
Song Y, Wang J, Huang H, Ma L, Wang J, Gu Y, Liu L, Lin Y (2012) Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321. Mar Drugs 10:340–348
Stierle A, Strobel G, Stierle D (1993) Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Sci N Y Then Wash 260:214
Stone V, Brown DM, Watt N, Wilson M, Donaldson K, Ritchie H, MacNee W (2000) Ultrafine particle-mediated activation of macrophages: intracellular calcium signaling and oxidative stress. Inhal Toxicol 12:345–351
Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502
Strobel G, Daisy B, Castillo U, Harper J (2004) Natural products, from endophytic microorganisms. J Nat Prod 67:257–268
Swarthout D, Harper E, Judd S, Gonthier D, Shyne R, Stowe T, Bultman T (2009) Measures of leaf-level water-use efficiency in drought stressed endophyte infected and non-infected tall fescue grasses. Environ Exp Bot 66:88–93
Tan RX, Zou WX (2001) Endophytes: a rich source of functional metabolites. Nat Prod Rep 18:448–459
Tan C, Liu Z, Chen S, Huang X, Cui H, Long Y, Lu Y, She Z (2016) Antioxidative polyketones from the mangrove-derived fungus Ascomycota sp. SK2YWS-L. Sci Rep 6:36609–36618
Thatoi HN, Patra JK, Das SK (2014) Free radical scavenging and antioxidant potential of mangrove plants: a review. Acta Physiol Plant 36:561–579
Wang J, Lu Z, Liu P, Wang Y, Li J, Hong K, Zhu W (2012) Cytotoxic polyphenols from the fungus Penicillium expansum 091006 endogenous with the mangrove plant Excoecaria agallocha. Planta Med 78:1861–1866
Wang J, Cox DG, Ding W, Huang G, Lin Y, Li C (2014) Three new resveratrol derivatives endophytic fungus Alternaria sp. Mar Drugs 12:2840–2850
Wenhan L, Liya L, Hongzheng F, Isabel S, Xueshi H, Susane G (2005) New cyclopentenone derivatives from an endophytic Streptomyces sp. isolated from the mangrove plant Aegiceras comiculatum. J Antibiot 58:594–598
Wiyakrutta S, Sriubolmas N, Panphut W, Thongon N, Danwisetkanjana K, Ruangrungsi N, Meevootisom V (2004) Endophytic fungi with anti-microbial, anti-cancer and anti-malarial activities isolated from Thai medicinal plants. World J Microbiol Biotechnol 20:265–272
Xia XK, Huang HR, She ZG, Cai JW, Lan L, Zhang JY, Fuc LW, Vrijmoed LLP, Lin YC (2007) Structural and biological properties of vermistatin and two new vermistatin derivatives isolated from the marine-mangrove endophytic fungus Guignardia sp. No. 4382. Helv Chim Acta 90:1925–1931
Xiaoling C, Xiaoli L, Shining Z, Junping G, Shuiping W, Xiaoming L, Zhigang S, Yongcheng L (2010) Cytotoxic and topoisomerase I inhibitory activities from extracts of endophytic fungi isolated from mangrove plants in Zhuhai, China. J Ecol Nat Environ 2:16–24
Xu J, Kjer J, Sendker J, Wray V, Guan H, Edrada RA, Lin WH, Wu J, Proksch P (2009) Chromones from the endophytic fungus Pestalotiopsis sp. Isolated from the Chinese Mangrove plant Rhizophora mucronata. J Nat Prod 72:662–665
Yan HJ, Lia XM, Lia CS, Wang BG (2012) Alkaloid and anthraquinone derivatives produced by the marine-derived endophytic fungus Eurotium rubrum. Helv Chim Acta 95:163–168
Yanagihara M, Sasaki-Takahashi N, Sugahara T, Yamamoto S, Shinomi M, Yamashita I, Hayashida M, Yamanoha B, Numata A, Yamori T, Andoh T (2005) Leptosins isolated from marine fungus Leptoshaeria species inhibit DNA topoisomerases I and/or II and induce apoptosis by inactivation of Akt/protein kinase B. Cancer Sci 96:816–824
Zhang JY, Wu HY, Xia XK, Liang YJ, Yan YY, She ZG, Lin YC, Fu LW (2007) Anthracenedione derivative 1403P-3 induces apoptosis in KB and KBv200 cells via reactive oxygen species-independent mitochondrial pathway and death receptor pathway. Cancer Biol Ther 6:1409–1416
Zhang JY, Tao LY, Liang YJ, Yan YY, Dai CL, Xia XK, She ZG, Lin YC, Fu LW (2009) Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G1 with involvement of GSK-3β/β-catenin/c-Myc pathway. Cell Cycle 8:2444–2450
Zhang J, Tao L, Liang Y, Chen L, Mi Y, Zheng L, Wang F, She Z, Lin Y, Wah KK, Fu L (2010) Anthracenedione derivatives as anticancer agents isolated from secondary metabolites of the mangrove endophytic fungi. Mar Drugs 8:1469–1481
Zhang G, Sun S, Zhu T, Lin Z, Gu J, Li D, Gu Q (2011) Antiviral isoindolone derivatives from an endophytic fungus Emericella sp. associated with Aegiceras corniculatum. Phytochemistry 72:1436–1442
Zhou H, Zhu T, Cai S, Gu Q, Li D (2011) Drimane sesquiterpenoids from the mangrove-derived fungus Aspergillus ustus. Chem Pharm Bull 59:762–766
Zhu F, Chen X, Yuan Y, Huang M, Sun H, Xiang W (2009) The chemical investigations of the mangrove plant Avicennia marina and its endophytes. Open Nat Prod J 2:24–32
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Das, S.K., Samantray, D., Thatoi, H.N. (2018). Pharmacological Applications of Metabolites of Mangrove Endophytes: A Review. In: Patra, J., Das, G., Shin, HS. (eds) Microbial Biotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-10-7140-9_16
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