Abstract
Caffeine is a kind of xanthine alkaloid and mainly found in coffee, tea, Paraguay Holly (Mate), and the fruit or leaf taken from guarana. Caffeine shows the function of dispelling fatigue and exciting nerve. The commonly used clinical preparations include caffeine sodium benzoate and ergotamine caffeine. The adverse reactions include nausea, vomiting, abdominal pain, and fatigue. Overdose of caffeine will cause damage to the human body. Due to addiction at high dose, caffeine is included in the scope of controlled psychotropic drugs. Caffeine is mainly metabolized in the liver, and only 1–5% of it is excreted as metabolites through urine. Theobromine is the main active metabolite of caffeine and reported to cause activities in the cardiovascular system.
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References
Yu-guan Z, Le S, Li X, et al. Caffeine in acute or chronic pain control and its possible mechanism. J Chin Acad Med Sci. 2014;6:697–700.
Chao-ran Y, Zhong-qing W. The pharmacological effects and application of caffeine. J Med Grad Stud. 2005;18(3):270–2.
Jia-bin H, Jing C, Wang J-k, et al. Progress in caffeine preparation methods. Chem Ind Vertical Horizontal. 2003;17(3):13–6.
Spriet LL. Exercise and sport performance with low doses of caffeine. Sports Med. 2014;44(2):S175–84.
Hai-xia L, Rong C, Dan Z. Progress in the synthesis and pharmacological effects of caffeine. Pharm J West Chin. 2011;2(2):182–7.
Pohanka M. The perspective of caffeine and caffeine derived compounds in therapy. Bratisl Lek Listy. 2015;116(9):520–30.
Ying C. Reevaluation of caffeine as a central stimulant. Foreign Med Physiol Pathol Sci Clin Pathol. 1997;4:375–8.
Yao C, Hong-hao Z. The research progress of caffeine metabolism and its application. Prog Physiol Sci. 2010;41(4):256–60.
Jian-liang F, Yu L. Comparison between imitrex injection and ergotamine caffeine tablets in the treatment of migraine. Chin J New Drugs Clin Remedies. 1999;2:82–4.
D’Ambrosio SM. Evaluation of the genotoxicity data on caffeine. Regul Toxicol Pharmacol. 1994;19(3):243–81.
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© 2018 Springer Nature Singapore Pte Ltd. and People's Medical Publishing House, PR of China
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Wang, L., Du, LD., Du, GH. (2018). Caffeine. In: Natural Small Molecule Drugs from Plants. Springer, Singapore. https://doi.org/10.1007/978-981-10-8022-7_32
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DOI: https://doi.org/10.1007/978-981-10-8022-7_32
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