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Molecular Components of Mechanotransduction Machinery

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Mechanotransduction of the Hair Cell

Part of the book series: SpringerBriefs in Biochemistry and Molecular Biology ((BRIEFSBIOCHEM))

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Abstract

After decades of intense investigation, the molecular components of mammalian hair-cell mechanotransduction (MET) machinery have started to emerge. Convincing evidences suggested that tip links are composed of two atypical cadherin proteins, protocadherin 15 (PCDH15) and cadherin 23 (CDH23). Meanwhile, the identity of the MET channel is still not confirmative, although several promising candidates have been put forward. In this chapter, we will first introduce the recent progress of our understanding of tip links, as well as the so-called upper and lower tip-link complexes associated with them. Then we will focus on the MET channel that lies at the heart of the MET machinery. TMC1, TMC2, LHFPL5, TMIE, and CIB2 have been suggested to be integral components of the machinery, but confirmative evidences for them as the pore-forming subunits of the channel are still missing. Lastly, we will briefly discuss the recent identification of PIEZO2 as the channel responsible for the reverse-polarity MET currents.

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    Zhigang Xu

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Xu, Z. (2018). Molecular Components of Mechanotransduction Machinery. In: Mechanotransduction of the Hair Cell. SpringerBriefs in Biochemistry and Molecular Biology. Springer, Singapore. https://doi.org/10.1007/978-981-10-8557-4_4

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