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ApoE and Neurodegenerative Diseases in Aging

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Aging and Aging-Related Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1086))

Abstract

Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE has three isoforms, ApoE2, ApoE3, and ApoE4, which are expressed by the polymorphic alleles: ɛ2, ɛ3, and ɛ4. Among the three polymorphic alleles, apoE ε4 is the most risk gene. ApoE is the main ligand for the low-density lipoprotein (LDL) receptor and the LDL receptor-related protein (LRP), functioning as the component of plasma lipoproteins in the transportation of lipids. Physiologically, ApoE is a multifunctional protein with central roles in lipid metabolism; it transports lipids, including cholesterol, through the cerebrospinal fluid (CSF) and plasma. ApoE expression regulation and apoE gene polymorphism have an important connection with neurological or neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), ischemic stroke, and other diseases.

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Acknowledgements

This work was financially supported by grants from the National Key R&D Program of China (2018YFD0400204), the Key International S&T Cooperation Program of China (2016YFE113700), the European Union’s Horizon 2020 Research and Innovation Program (633589) and the National Natural Science Foundation of China (81471396).

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  1. MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Yuemiao Yin

  2. School of Pharmaceutical Sciences, Tsinghua University, Beijing, China

    Zhao Wang

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    Zhao Wang

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Yin, Y., Wang, Z. (2018). ApoE and Neurodegenerative Diseases in Aging. In: Wang, Z. (eds) Aging and Aging-Related Diseases. Advances in Experimental Medicine and Biology, vol 1086. Springer, Singapore. https://doi.org/10.1007/978-981-13-1117-8_5

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