Abstract
Acute generalized exanthematous pustulosis (AGEP) is a rare, severe, pustular reaction pattern, attributed mainly to drugs. Other triggers such as infections, spider bite, and contact sensitivity have been implicated. AGEP is characterized by typical morphology, unique histology, and a rapid clinical course. The AGEP validation score (EuroSCAR group criteria) is a useful tool for establishing the diagnosis. The immune pathogenesis involves drug-specific T-cells, neutrophils, and the release of cytokines/chemokines (i.e., IL-8/CXCL8). In view of the remarkable clinical and histological similarity between AGEP and pustular psoriasis, the genetic basis of AGEP should be further evaluated.
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Abbreviations
- AGEP:
-
Acute generalized exanthematous pustulosis
- ALEP:
-
Acute localized exanthematous pustulosis
- DRESS:
-
Drug reaction with eosinophilia and systemic symptoms
- GPP:
-
Generalized pustular psoriasis
- HLA:
-
Human leukocyte antigen
- IL36-Ra:
-
IL-36 receptor antagonist
- NSAID:
-
Non-steroidal anti-inflammatory drug
- SCAR:
-
Severe cutaneous adverse reaction
- TEN:
-
Toxic epidermal necrolysis
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Halevy, S. (2019). Acute Generalized Exanthematous Pustulosis. In: Shear, N., Dodiuk-Gad, R. (eds) Advances in Diagnosis and Management of Cutaneous Adverse Drug Reactions. Adis, Singapore. https://doi.org/10.1007/978-981-13-1489-6_8
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