Skip to main content
SpringerLink
Log in

Quantitative Analysis of Retinal Layers’ Optical Intensities Based on Optical Coherence Tomography

  • Chapter
  • First Online:
Retinal Optical Coherence Tomography Image Analysis

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

In addition to the morphologic parameters of retinal structures, OCT images also provide the signal/reflection intensity information, which is however much less studied. This chapter introduces several studies on the quantitative analysis of the retinal layers’ optical intensity, both for normal subjects and for patients with central retinal artery occlusion.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. V.J. Srinivasan, D.C. Adler, Y. Chen, I. Gorczynska, R. Huber, J.S. Duker, J.S. Schuman, J.G. Fujimoto, Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head. Invest. Ophthalmol. Vis. Sci. 49(11), 5103–5110 (2008)

    Article  Google Scholar 

  2. W. Geitzenauer, C.K. Hitzenberger, U.M. Schmidt-Erfurth, Retinal optical coherence tomography: past, present and future perspectives. Br. J. Ophthalmol. 95(2), 171–177 (2011)

    Article  Google Scholar 

  3. B. Yang, C. Ye, M. Yu, S. Liu, D.S. Lam, C.K. Leung, Optic disc imaging with spectral-domain optical coherence tomography: variability and agreement study with Heidelberg retinal tomograph. Ophthalmology 119(9), 1852–1857 (2012)

    Article  Google Scholar 

  4. M.S. Sung, B.W. Kang, H.G. Kim, H. Heo, S.W. Park, Clinical validity of macular ganglion cell complex by spectral domain-optical coherence tomography in advanced glaucoma. J. Glaucoma. (2012)

    Google Scholar 

  5. L. Zhang, K. Lee, M. Niemeijer, R.F. Mullins, M. Sonka, M.D. Abràmoff, Automated segmentation of the choroid from clinical SD-OCT. Invest. Ophthalmol. Vis. Sci. 53 (2012)

    Article  Google Scholar 

  6. H. Ozdemir, S. Karacorlu, M. Karacorlu, Optical coherence tomography findings in central retinal artery occlusion. Retina 26(1), 110–112 (2006)

    Article  Google Scholar 

  7. T. Fukuchi, K. Takahashi, H. Ida, K. Sho, M. Matsumura, Staging of idiopathic choroidal neovascularization by optical coherence tomography. Graefes Arch. Clin. Exp. Ophthalmol. 239(6), 424–429 (2001)

    Article  Google Scholar 

  8. M.E. Pons, H. Ishikawa, R. Gürsesozden, J.M. Liebmann, H.L. Dou, R. Ritch, Assessment of retinal nerve fiber layer internal reflectivity in eyes with and without glaucoma using optical coherence tomography. Arch. Ophthalmol. 118(8), 1044–1047 (2000)

    Article  Google Scholar 

  9. J. Van der Schoot, K.A. Vermeer, J.F. de Boer, H.G. Lemij, The effect of glaucoma on the optical attenuation coefficient of the retinal nerve fiber layer in spectral domain optical coherence tomography images. Invest. Ophthalmol. Vis. Sci. 53(4), 2424–2430 (2012)

    Article  Google Scholar 

  10. D. Barthelmes, F.K. Sutter, M.C. Gillies, Differential optical densities of intraretinal spaces. Invest. Ophthalmol. Vis. Sci. 49(8), 3529–3534 (2008)

    Article  Google Scholar 

  11. S.Y. Lee, P.F. Stetson, H. Ruiz-Garcia, F.M. Heussen, S.R. Sadda, Automated characterization of pigment epithelial detachment by optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 53(53), 164–170 (2012)

    Article  Google Scholar 

  12. T. Horii, T. Murakami, K. Nishijima, T. Akagi, A. Uji, N. Arakawa, Y. Muraoka, N. Yoshimura, Relationship between fluorescein pooling and optical coherence tomographic reflectivity of cystoid spaces in diabetic macular edema. Ophthalmology 119(5), 1047–1055 (2012)

    Article  Google Scholar 

  13. D. Barthelmes, M.C. Gillies, F.K. Sutter, Quantitative OCT analysis of idiopathic perifoveal telangiectasia. Invest. Ophthalmol. Vis. Sci. 49(5), 2156–2162 (2008)

    Article  Google Scholar 

  14. J. Van der Schoot, K.A. Vermeer, J.F. de Boer, H.G. Lemij, The effect of glaucoma on the optical attenuation coefficient of the retinal nerve fiber layer in spectral domain optical coherence tomography images. Invest. Ophthalmol. Vis. Sci. 53(4), 2424–30 (2012)

    Article  Google Scholar 

  15. K.A. Vermeer, J. van der Schoot, H.G. Lemij, J.F. de Boer, RPE-normalized RNFL attenuation coefficient maps derived from volumetric OCT imaging for glaucoma assessment. Invest. Ophthalmol. Vis. Sci. 53(10), 6102–6108 (2012)

    Article  Google Scholar 

  16. A. Giani, D.D. Esmaili, C. Luiselli, M. Cigada, P. Salvetti, J.W. Miller, G. Staurenghi, Displayed reflectivity of choroidal neovascular membranes by optical coherence tomography correlates with presence of leakage by fluorescein angiography. Retina 31(5), 942–948 (2011)

    Article  Google Scholar 

  17. S. Ooto, M. Hangai, A. Tomidokoro, H. Saito, M. Araie, T. Otani, S. Kishi, K. Matsushita, N. Maeda, M. Shirakashi, H. Abe, S. Ohkubo, K. Sugiyama, A. Iwase, N. Yoshimura, Effects of age, sex, and axial length on the three-dimensional profile of normal macular layer structures. Invest. Ophthalmol. Vis. Sci. 52(12), 8769–8779 (2011)

    Article  Google Scholar 

  18. C.Y. Cheung, D. Chen, T.Y. Wong, Y.C. Tham, R. Wu, Y. Zheng, C.Y. Cheng, S.M. Saw, M. Baskaran, C.K. Leung, T. Aung, Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects. Invest. Ophthalmol. Vis. Sci. 52(13), 9629–9635 (2011)

    Article  Google Scholar 

  19. T. Alasil, K. Wang, P.A. Keane, H. Lee, N. Baniasadi, J.F. de Boer, T.C. Chen, Analysis of normal retinal nerve fiber layer thickness by age, sex, and race using spectral domain optical coherence tomography. J. Glaucoma 22(7), 532–541 (2013)

    Article  Google Scholar 

  20. M.D. Abràmoff, M.K. Garvin, M. Sonka, Retinal imaging and image analysis. IEEE Trans. Med. Imaging 3, 169–208 (2010)

    Google Scholar 

  21. M.K. Garvin, M.D. Abràmoff, X. Wu et al., Automated 3-D intraretinal layer segmentation of macular spectral-domain optical coherence tomography images. IEEE Trans. Med. Imaging 28(9), 1436–1447 (2009)

    Article  Google Scholar 

  22. X. Chen, M. Niemeijer, L. Zhang, K. Lee, M.D. Abramoff, M. Sonka, 3D segmentation of fluid-associated abnormalities in retinal OCT: probability constrained graph-search–graph-cut. Med. Imaging IEEE Trans. 31(8), 1521–1531 (2012)

    Article  Google Scholar 

  23. F. Shi, X. Chen, H. Zhao, W. Zhu, D. Xiang, E. Gao, M. Sonka, H. Chen, Automated 3-D retinal layer segmentation of macular optical coherence tomography images with serous pigment epithelial detachments. IEEE Trans. Med. Imaging 34(2), 441–452 (2015)

    Article  Google Scholar 

  24. X. Chen, P. Hou, C. Jin, W. Zhu, X. Luo, F. Shi, M. Sonka, H. Chen, Quantitative analysis of retinal layer optical intensities on three-dimensional optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 54(10), 6846 (2013)

    Article  Google Scholar 

  25. B. Chen, E. Gao, H. Chen, J. Yang, F. Shi, C. Zheng, W. Zhu, D. Xiang, X. Chen, M. Zhang, Profile and determinants of retinal optical intensity in normal eyes with spectral domain optical coherence tomography. Plos One 11(2) (2016)

    Article  Google Scholar 

  26. Retinopathy/Pathology D. Photocoagulation for diabetic macular edema. Early treatment diabetic retinopathy study report number 1. Early Treatment Diabetic Retinopathy Study research group. Arch. Ophthalmol. 103(12), 1796–806 (1985)

    Google Scholar 

  27. H. Chen, X. Chen, Z. Qiu, D. Xiang, W. Chen, F. Shi, J. Zheng, W. Zhu, M. Sonka, Quantitative analysis of retinal layers’ optical intensities on 3D optical coherence tomography for central retinal artery occlusion. Sci. Rep. 5(10), 6846–6851 (2015)

    Google Scholar 

  28. C.K. Leung, C.Y. Cheung, R.N. Weinreb, Q. Qiu, S. Liu, H. Li, G. Xu, N. Fan, L. Huang, C.P. Pang, D.S. Lam, Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study. Ophthalmology 116(7), 1257–1263, 63 e1-2 (2009)

    Google Scholar 

  29. C.K. Leung, M. Yu, R.N. Weinreb, C. Ye, S. Liu, Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a prospective analysis of age-related loss. Ophthalmology 119(4), 731–737 (2012)

    Article  Google Scholar 

  30. S. Cugati, D.D. Varma, C.S. Chen, A.W. Lee, Treatment options for central retinal artery occlusion. Current Treat. Options Neurol. 15(1), 63–77 (2013)

    Article  Google Scholar 

  31. N.G. Ghazi, E.P. Tilton, B. Patel, R.M. Knape, S.A. Newman, Comparison of macular optical coherence tomography findings between postacute retinal artery occlusion and nonacute optic neuropathy. Retina 30(4), 578–585 (2010)

    Article  Google Scholar 

  32. R. Mathew, E. Papavasileiou, S. Sivaprasad, Autofluorescence and high-definition optical coherence tomography of retinal artery occlusions. Clin. Ophthalmol. 4(1), 1159–1163 (2009)

    Google Scholar 

  33. C.K. Leung, C.C. Tham, S. Mohammed, E.Y. Li, K.S. Leung, W.M. Chan, D.S. Lam, In vivo measurements of macular and nerve fibre layer thickness in retinal arterial occlusion. Eye 21(12), 1464–1468 (2007). (London, England)

    Article  Google Scholar 

  34. D. Schmidt, T. Kube, N. Feltgen, Central retinal artery occlusion: findings in optical coherence tomography and functional correlations. Eur. J. Med. Res. 11(6), 250–252 (2006)

    Google Scholar 

  35. K. Shinoda, K. Yamada, C.S. Matsumoto, K. Kimoto, K. Nakatsuka, Changes in retinal thickness are correlated with alterations of electroretinogram in eyes with central retinal artery occlusion. Graefe’s Arch. Clin. Exp. Ophthalmol. 246(7), 949–954 (2008)

    Article  Google Scholar 

  36. M. Ritter, S. Sacu, G.G. Deák, K. Kircher, R.G. Sayegh, C. Pruente, U.M. Schmidt-Erfurth, In vivo identification of alteration of inner neurosensory layers in branch retinal artery occlusion. Br. J. Ophthalmol. 96(2), 201–207 (2012)

    Article  Google Scholar 

  37. S.M. Falkenberry, M.S. Ip, B.A. Blodi, J.B. Gunther, Optical coherence tomography findings in central retinal artery occlusion. Ophthalmic Surg. Lasers Imaging Official J. Int. Soc. Imaging Eye 37(6), 502–505 (2006)

    Google Scholar 

  38. H. Ozdemir, M. Karacorlu, S.A. Karacorlu, F. Senturk, Localized foveal detachment in a patient with central retinal artery occlusion with cilioretinal sparing. Eur. J. Ophthalmol. 22(3), 492–494 (2012)

    Article  Google Scholar 

  39. H. Kolb, Simple Anatomy of the Retina (2013) http://webvision.med.utah.edu/book/part-i-foundations/simple-anatomy-of-the-retina/. Date of access: 21 Jan 2015

  40. N. Goldenberg-Cohen, S. Dadon, B.-C.R. Avraham, M. Kramer, M. Hasanreisoglu, I. Eldar, D. Weinberger, I. Bahar, Molecular and histological changes following central retinal artery occlusion in a mouse model ☆. Exp. Eye Res. 87(4), 327–333 (2008)

    Article  Google Scholar 

  41. S. Yu, F. Wang, C.E. Pang, L.A. Yannuzzi, K.B. Freund, Multimodal imaging findings in retinal deep capillary ischemia. Retina 34(4), 636–646 (2014)

    Article  Google Scholar 

  42. L.E. Zimmerman, Embolism of central retinal artery; secondary to myocardial infarction with mural thrombosis. Arch. Ophthalmol. 73, 822–826 (1965)

    Article  Google Scholar 

  43. J.C. Suvarna, S.A. Hajela, Cherry-red spot. J. Postgrad. Med. 54(1), 54–57 (2008)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Electronics and Information Engineering, Soochow University, Suzhou, China

    Enting Gao, Fei Shi & Xinjian Chen

  2. State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China

    Xinjian Chen

  3. Joint Shantou International Eye Center, Shantou University, Chinese University of Hong Kong, Shantou, China

    Haoyu Chen

Authors
  1. Enting Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fei Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Haoyu Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xinjian Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xinjian Chen .

Editor information

Editors and Affiliations

  1. School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, China

    Xinjian Chen

  2. School of Electronic and Information Engineering, Soochow University, Suzhou, Jiangsu, China

    Fei Shi

  3. Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, China

    Haoyu Chen

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Science Press and Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Gao, E., Shi, F., Chen, H., Chen, X. (2019). Quantitative Analysis of Retinal Layers’ Optical Intensities Based on Optical Coherence Tomography. In: Chen, X., Shi, F., Chen, H. (eds) Retinal Optical Coherence Tomography Image Analysis. Biological and Medical Physics, Biomedical Engineering. Springer, Singapore. https://doi.org/10.1007/978-981-13-1825-2_7

Download citation

Publish with us

Policies and ethics

Search

Navigation