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Skin Changes During Ageing

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Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Part of the book series: Subcellular Biochemistry ((SCBI,volume 91))

Abstract

The skin provides the primary protection for the body against external injuries and is essential in the maintenance of general homeostasis. During ageing, resident cells become senescent and the extracellular matrix, mainly in the dermis, is progressively damaged affecting the normal organization of the skin and its capacity for repair. In parallel, extrinsic factors such as ultraviolet irradiation, pollution, and intrinsic factors such as diabetes or vascular disease can further accelerate this phenomenon. Indeed, numerous mechanisms are involved in age-induced degradation of the skin and these also relate to non-healing or chronic wounds in the elderly. In particular, the generation of reactive oxygen species seems to play a major role in age-related skin modifications. Certainly, targeting both the hormonal status of the skin or its surface nutrition can slow down age-induced degradation of the skin and improve healing of skin damage in the elderly. Skin care regimens that prevent radiation and pollution damage, and reinforce the skin surface and its microbiota are among the different approaches able to minimize the effects of ageing on the skin.

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Abbreviations

ADSC:

adipose tissue-derived stem cell

AGEs:

advanced glycation end-products

AMPK:

adenosine monophosphate-activated protein kinase

AP-1:

activator protein-1

CR:

caloric restriction

CTGF:

connective tissue growth factor

DEJ:

dermal-epidermal junction

ECM:

extracellular matrix

HSD:

hydroxysteroid dehydrogenase

IL:

interleukin

IR:

infrared radiation

MB:

methylene blue

MMP:

matrix metalloproteinase

MSC:

mesenchymal stem cell

NT:

neurotrophin

PDGF:

platelet-derived growth factor

ROS:

reactive oxygen species

SOD:

superoxide dismutase

TGF-β1:

transforming growth factor-β1

TIMPs:

tissue inhibitors of metalloproteinases

TNF-α:

tumour necrosis factor-α

UV:

ultraviolet

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Authors and Affiliations

  1. LVMH Recherche, Saint Jean de Braye, France

    Frédéric Bonté & Jean-Christophe Archambault

  2. Faculties of Medicine and Pharmacy, Department of Physiology, University of Limoges, Myelin Maintenance and Peripheral Neuropathies (EA 6309), Limoges, France

    Dorothée Girard & Alexis Desmoulière

  3. Institut de Recherche Biomédicale des Armées, INSERM UMRS-MD 1197, Centre de Transfusion Sanguine des Armées, Clamart, France

    Dorothée Girard

Authors
  1. Frédéric Bonté
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  2. Dorothée Girard
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  3. Jean-Christophe Archambault
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  4. Alexis Desmoulière
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Corresponding author

Correspondence to Alexis Desmoulière .

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Editors and Affiliations

  1. Institute of Zoology, University of Mainz, Mainz, Germany

    J. Robin Harris

  2. Newcastle University, Newcastle upon Tyne, UK

    Viktor I. Korolchuk

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Bonté, F., Girard, D., Archambault, JC., Desmoulière, A. (2019). Skin Changes During Ageing. In: Harris, J., Korolchuk, V. (eds) Biochemistry and Cell Biology of Ageing: Part II Clinical Science. Subcellular Biochemistry, vol 91. Springer, Singapore. https://doi.org/10.1007/978-981-13-3681-2_10

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