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Software-Aided Design of Idealised Programmable Nucleic Acid Circuits

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Advances in Synthetic Biology

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Abstract

The idea to use nucleic acid as a substrate for design of programmable biomolecular circuits was first introduced almost four decades ago; however, up till now, the field of DNA computing holds many challenges and uncertainties to be discovered. This chapter describes the historical evolution of DNA programming along with its most noticeable breakthroughs till the current days, describes the basics of such important theoretical concepts as DNA strand displacement and Abstract Chemical Reaction Networks, and finally, familiarises the reader with various platforms for in silico synthesis and simulation of genetic circuits.

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Acknowledgements

This research is supported, in parts, by the EPSRC INDUSTRIAL CASE AWARD (CASE Voucher 16000070), Microsoft Research, and the EPSRC/BBSRC grant BB/M017982/1 to the Warwick Integrative Synthetic Biology Centre.

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Authors and Affiliations

  1. School of Engineering, University of Warwick, Coventry, UK

    Iuliia Zarubiieva & Vishwesh Kulkarni

Authors
  1. Iuliia Zarubiieva
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  2. Vishwesh Kulkarni
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Corresponding author

Correspondence to Vishwesh Kulkarni .

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Editors and Affiliations

  1. Department of Biosciences, School of Science, Indrashil University, Mehsana, Gujarat, India

    Vijai Singh

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Zarubiieva, I., Kulkarni, V. (2020). Software-Aided Design of Idealised Programmable Nucleic Acid Circuits. In: Singh, V. (eds) Advances in Synthetic Biology. Springer, Singapore. https://doi.org/10.1007/978-981-15-0081-7_8

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