Abstract
Nanoparticles (NPs) due to their extraordinary properties offer to revolutionize diverse areas of our life from consumer products to biomedical applications. With the better understanding and advancement of new techniques, a wide range of nanoparticles can be synthesized according to our requirement. However, a major concern lies in their impact on human health. Therefore, need of the present time before its incorporation in consumer products is to first evaluate various parameters like physico-chemical properties, dosage, trans-generational effect, etc. in an in vivo condition.
Drosophila and many other model organisms have been extensively used to evaluate in vivo effect of nanoparticles as many basic biological, physiological, and neurological properties are conserved between mammals and these model organisms. Therefore, in the present chapter, we have described about various model organisms implied in appraising effect of nanoparticles in in vivo condition. Consideration of the observations of these studies will further help in betterment of nano-unified consumer and medical products with least side effect on human health.
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References
Abou-Saleh H, Younes N, Rasool K, Younis MH, Prieto RM, Yassine HM, Mahmoud KA, Pintus G, Nasrallah GK (2019) Impaired liver size and compromised neurobehavioral activity are elicited by chitosan nanoparticles in the zebrafish embryo model. Nanomaterials (Basel) 9(1):122. https://doi.org/10.3390/nano9010122
Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y (2008) DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol 233(3):404–410. https://doi.org/10.1016/j.taap.2008.09.015
Ahamed M, Posgai R, Gorey TJ, Nielsen M, Hussain SM, Rowe JJ (2010a) Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol 242(3):263–269. https://doi.org/10.1016/j.taap.2009.10.016
Ahamed M, Siddiqui MA, Akhtar MJ, Ahmad I, Pant AB, Alhadlaq HA (2010b) Genotoxic potential of copper oxide nanoparticles in human lung epithelial cells. Biochem Biophys Res Commun 396(2):578–583. https://doi.org/10.1016/j.bbrc.2010.04.156
Ahamed M, Akhtar MJ, Siddiqui MA, Ahmad J, Musarrat J, Al-Khedhairy AA, AlSalhi MS, Alrokayan SA (2011) Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells. Toxicology 283(2–3):101–108. https://doi.org/10.1016/j.tox.2011.02.010
Anand AS, Prasad DN, Singh SB, Kohli E (2017) Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster. J Hazard Mater 327:180–186. https://doi.org/10.1016/j.jhazmat.2016.12.040
Armstrong N, Ramamoorthy M, Lyon D, Jones K, Duttaroy A (2013) Mechanism of silver nanoparticles action on insect pigmentation reveals intervention of copper homeostasis. PLoS One 8(1):e53186. https://doi.org/10.1371/journal.pone.0053186
Asharani PV, Lian Wu Y, Gong Z, Valiyaveettil S (2008) Toxicity of silver nanoparticles in zebrafish models. Nanotechnology 19(25):255102. https://doi.org/10.1088/0957-4484/19/25/255102
Auffan M, Decome L, Rose J, Orsiere T, De Meo M, Briois V, Chaneac C, Olivi L, Berge-Lefranc JL, Botta A, Wiesner MR, Bottero JY (2006) In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: a physicochemical and cyto-genotoxical study. Environ Sci Technol 40(14):4367–4373. https://doi.org/10.1021/es060691k
Avalos A, Haza AI, Morales P (2015) Manufactured silver nanoparticles of different sizes induced DNA strand breaks and oxidative DNA damage in hepatoma and leukaemia cells and in dermal and pulmonary fibroblasts. Folia Biol (Praha) 61(1):33–42
Baeg E, Sooklert K, Sereemaspun A (2018) Copper oxide nanoparticles cause a dose-dependent toxicity via inducing reactive oxygen species in Drosophila. Nanomaterials (Basel) 8(10):824. https://doi.org/10.3390/nano8100824
Barnes CA, Elsaesser A, Arkusz J, Smok A, Palus J, Lesniak A, Salvati A, Hanrahan JP, Jong WH, Dziubaltowska E, Stepnik M, Rydzynski K, McKerr G, Lynch I, Dawson KA, Howard CV (2008) Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity. Nano Lett 8(9):3069–3074. https://doi.org/10.1021/nl801661w
Bhattacharya K, Davoren M, Boertz J, Schins RP, Hoffmann E, Dopp E (2009) Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells. Part Fibre Toxicol 6:17. https://doi.org/10.1186/1743-8977-6-17
Böhme S, Baccaro M, Schmidt M, Potthoff A, Stärk H-J, Reemtsma T, Kühnel D (2017) Metal uptake and distribution in the zebrafish (Danio rerio) embryo: differences between nanoparticles and metal ions. Environ Sci: Nano 4(5):1005–1015
Borm PJ, Robbins D, Haubold S, Kuhlbusch T, Fissan H, Donaldson K, Schins R, Stone V, Kreyling W, Lademann J, Krutmann J, Warheit D, Oberdorster E (2006) The potential risks of nanomaterials: a review carried out for ECETOC. Part Fibre Toxicol 3:11. https://doi.org/10.1186/1743-8977-3-11
Cassee FR, Muijser H, Duistermaat E, Freijer JJ, Geerse KB, Marijnissen JC, Arts JH (2002) Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model. Arch Toxicol 76(5–6):277–286. https://doi.org/10.1007/s00204-002-0344-8
Chakraborty C, Agoramoorthy G (2010) Why zebrafish? Riv Biol 103(1):25–27
Chen TH, Lin CY, Tseng MC (2011) Behavioral effects of titanium dioxide nanoparticles on larval zebrafish (Danio rerio). Mar Pollut Bull 63(5–12):303–308. https://doi.org/10.1016/j.marpolbul.2011.04.017
Chen H, Wang B, Feng W, Du W, Ouyang H, Chai Z, Bi X (2015) Oral magnetite nanoparticles disturb the development of Drosophila melanogaster from oogenesis to adult emergence. Nanotoxicology 9(3):302–312. https://doi.org/10.3109/17435390.2014.929189
Chifiriuc MC, Ratiu AC, Popa M, Ecovoiu AA (2016) Drosophotoxicology: an emerging research area for assessing nanoparticles interaction with living organisms. Int J Mol Sci 17(2):36. https://doi.org/10.3390/ijms17020036
Choi O, Hu Z (2008) Size dependent and reactive oxygen species related nanosilver toxicity to nitrifying bacteria. Environ Sci Technol 42(12):4583–4588. https://doi.org/10.1021/es703238h
Choi JS, Kim RO, Yoon S, Kim WK (2016) Developmental toxicity of zinc oxide nanoparticles to zebrafish (Danio rerio): a transcriptomic analysis. PLoS One 11(8):e0160763. https://doi.org/10.1371/journal.pone.0160763
Crosera M, Prodi A, Mauro M, Pelin M, Florio C, Bellomo F, Adami G, Apostoli P, De Palma G, Bovenzi M, Campanini M, Filon FL (2015) Titanium dioxide nanoparticle penetration into the skin and effects on HaCaT cells. Int J Environ Res Public Health 12(8):9282–9297. https://doi.org/10.3390/ijerph120809282
Delcroix GJ, Jacquart M, Lemaire L, Sindji L, Franconi F, Le Jeune JJ, Montero-Menei CN (2009) Mesenchymal and neural stem cells labeled with HEDP-coated SPIO nanoparticles: in vitro characterization and migration potential in rat brain. Brain Res 1255:18–31. https://doi.org/10.1016/j.brainres.2008.12.013
Duan J, Yu Y, Shi H, Tian L, Guo C, Huang P, Zhou X, Peng S, Sun Z (2013) Toxic effects of silica nanoparticles on zebrafish embryos and larvae. PLoS One 8(9):e74606. https://doi.org/10.1371/journal.pone.0074606
Duan J, Liang S, Yu Y, Li Y, Wang L, Wu Z, Chen Y, Miller MR, Sun Z (2018) Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos. Nanotoxicology 12(5):470–484. https://doi.org/10.1080/17435390.2018.1461267
Feng H, Pyykko I, Zou J (2015) Hyaluronan up-regulation is linked to renal dysfunction and hearing loss induced by silver nanoparticles. Eur Arch Otorhinolaryngol 272(10):2629–2642. https://doi.org/10.1007/s00405-014-3213-1
Foldbjerg R, Dang DA, Autrup H (2011) Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549. Arch Toxicol 85(7):743–750. https://doi.org/10.1007/s00204-010-0545-5
Gaiser BK, Fernandes TF, Jepson M, Lead JR, Tyler CR, Stone V (2009) Assessing exposure, uptake and toxicity of silver and cerium dioxide nanoparticles from contaminated environments. Environ Health 8 Suppl 1:S2. https://doi.org/10.1186/1476-069X-8-S1-S2
Galeone A, Vecchio G, Malvindi MA, Brunetti V, Cingolani R, Pompa PP (2012) In vivo assessment of CdSe-ZnS quantum dots: coating dependent bioaccumulation and genotoxicity. Nanoscale 4(20):6401–6407. https://doi.org/10.1039/c2nr31826a
Gao G, Ze Y, Li B, Zhao X, Zhang T, Sheng L, Hu R, Gui S, Sang X, Sun Q, Cheng J, Cheng Z, Wang L, Tang M, Hong F (2012) Ovarian dysfunction and gene-expressed characteristics of female mice caused by long-term exposure to titanium dioxide nanoparticles. J Hazard Mater 243:19–27. https://doi.org/10.1016/j.jhazmat.2012.08.049
Geffroy B, Ladhar C, Cambier S, Treguer-Delapierre M, Brethes D, Bourdineaud JP (2012) Impact of dietary gold nanoparticles in zebrafish at very low contamination pressure: the role of size, concentration and exposure time. Nanotoxicology 6(2):144–160. https://doi.org/10.3109/17435390.2011.562328
Gonzalez-Moragas L, Roig A, Laromaine A (2015) C. elegans as a tool for in vivo nanoparticle assessment. Adv Colloid Interface Sci 219:10–26. https://doi.org/10.1016/j.cis.2015.02.001
Gopalan RC, Osman IF, Amani A, Matas MD, Anderson D (2009) The effect of zinc oxide and titanium dioxide nanoparticles in the Comet assay with UVA photoactivation of human sperm and lymphocytes. Nanotoxicology 3(1):33–39. https://doi.org/10.1080/17435390802596456
Gorth DJ, Rand DM, Webster TJ (2011) Silver nanoparticle toxicity in Drosophila: size does matter. Int J Nanomedicine 6:343–350. https://doi.org/10.2147/ijn.S16881
Greish K, Alqahtani AA, Alotaibi AF, Abdulla AM, Bukelly AT, Alsobyani FM, Alharbi GH, Alkiyumi IS, Aldawish MM, Alshahrani TF, Pittalà V, Taurin S, Kamal A (2019) The effect of silver nanoparticles on learning, memory and social interaction in BALB/C mice. Int J Environ Res Public Health 16(1):148
Guan R, Kang T, Lu F, Zhang Z, Shen H, Liu M (2012) Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles. Nanoscale Res Lett 7(1):602. https://doi.org/10.1186/1556-276X-7-602
Gurr JR, Wang AS, Chen CH, Jan KY (2005) Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213(1–2):66–73. https://doi.org/10.1016/j.tox.2005.05.007
Hsiao MT, Chen SF, Shieh DB, Yeh CS (2006) One-pot synthesis of hollow Au3Cu1 spherical-like and biomineral botallackite Cu2(OH)3Cl flowerlike architectures exhibiting antimicrobial activity. J Phys Chem B 110(1):205–210. https://doi.org/10.1021/jp054827x
Hulme SE, Whitesides GM (2011) Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research. Angew Chem Int Ed Engl 50(21):4774–4807. https://doi.org/10.1002/anie.201005461
Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ (2005) In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 19(7):975–983. https://doi.org/10.1016/j.tiv.2005.06.034
Hussain S, Thomassen LC, Ferecatu I, Borot MC, Andreau K, Martens JA, Fleury J, Baeza-Squiban A, Marano F, Boland S (2010) Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells. Part Fibre Toxicol 7:10. https://doi.org/10.1186/1743-8977-7-10
Jin Y, Kannan S, Wu M, Zhao JX (2007) Toxicity of luminescent silica nanoparticles to living cells. Chem Res Toxicol 20(8):1126–1133. https://doi.org/10.1021/tx7001959
Kang SJ, Kim BM, Lee YJ, Chung HW (2008) Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Environ Mol Mutagen 49(5):399–405. https://doi.org/10.1002/em.20399
Karlsson HL, Cronholm P, Gustafsson J, Moller L (2008) Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. Chem Res Toxicol 21(9):1726–1732. https://doi.org/10.1021/tx800064j
Kennedy LC, Bickford LR, Lewinski NA, Coughlin AJ, Hu Y, Day ES, West JL, Drezek RA (2011) A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies. Small 7(2):169–183. https://doi.org/10.1002/smll.201000134
Key S, Reaves D, Turner F, Bang J (2011) Impacts of silver nanoparticle ingestion on pigmentation and developmental progression in Drosophila. Atlas J Biol 1:52–61. https://doi.org/10.5147/ajb.2011.0048
Kim YS, Kim JS, Cho HS, Rha DS, Kim JM, Park JD, Choi BS, Lim R, Chang HK, Chung YH, Kwon IH, Jeong J, Han BS, Yu IJ (2008) Twenty-eight-day oral toxicity, genotoxicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats. Inhal Toxicol 20(6):575–583. https://doi.org/10.1080/08958370701874663
Kim SW, Nam SH, An YJ (2012) Interaction of silver nanoparticles with biological surfaces of Caenorhabditis elegans. Ecotoxicol Environ Saf 77:64–70. https://doi.org/10.1016/j.ecoenv.2011.10.023
Korani M, Rezayat SM, Arbabi Bidgoli S (2013) Sub-chronic dermal toxicity of silver nanoparticles in Guinea pig: special emphasis to heart, bone and kidney toxicities. Iran J Pharm Res 12(3):511–519
Kroll A, Pillukat MH, Hahn D, Schnekenburger J (2009) Current in vitro methods in nanoparticle risk assessment: limitations and challenges. Eur J Pharm Biopharm 72(2):370–377. https://doi.org/10.1016/j.ejpb.2008.08.009
Kuku G, Culha M (2017) Investigating the origins of toxic response in TiO(2) nanoparticle-treated cells. Nanomaterials (Basel) 7(4):83. https://doi.org/10.3390/nano7040083
Lee KJ, Nallathamby PD, Browning LM, Osgood CJ, Xu XH (2007) In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1(2):133–143. https://doi.org/10.1021/nn700048y
Li JJ, Yung LYL, Hartono D, Bay BH, Zou L, Ong CN (2008) Gold nanoparticles induce oxidative damage in lung fibroblasts in vitro. Adv Mater 20:138–142
Lindberg HK, Falck GC, Catalan J, Koivisto AJ, Suhonen S, Jarventaus H, Rossi EM, Nykasenoja H, Peltonen Y, Moreno C, Alenius H, Tuomi T, Savolainen KM, Norppa H (2012) Genotoxicity of inhaled nanosized TiO(2) in mice. Mutat Res 745(1–2):58–64. https://doi.org/10.1016/j.mrgentox.2011.10.011
Liu X, Vinson D, Abt D, Hurt RH, Rand DM (2009) Differential toxicity of carbon nanomaterials in Drosophila: larval dietary uptake is benign, but adult exposure causes locomotor impairment and mortality. Environ Sci Technol 43(16):6357–6363. https://doi.org/10.1021/es901079z
Lovern SB, Klaper R (2006) Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles. Environ Toxicol Chem 25(4):1132–1137
Ma Y, Bao J, Zhang Y, Li Z, Zhou X, Wan C, Huang L, Zhao Y, Han G, Xue T (2019) Mammalian near-infrared image vision through injectable and self-powered retinal nanoantennae. Cell 177(2):243–255.e215. https://doi.org/10.1016/j.cell.2019.01.038
Manna SK, Sarkar S, Barr J, Wise K, Barrera EV, Jejelowo O, Rice-Ficht AC, Ramesh GT (2005) Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-κB in human keratinocytes. Nano Lett 5(9):1676–1684
Mao BH, Chen ZY, Wang YJ, Yan SJ (2018) Silver nanoparticles have lethal and sublethal adverse effects on development and longevity by inducing ROS-mediated stress responses. Sci Rep 8(1):2445. https://doi.org/10.1038/s41598-018-20728-z
Meyer JN, Lord CA, Yang XY, Turner EA, Badireddy AR, Marinakos SM, Chilkoti A, Wiesner MR, Auffan M (2010) Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans. Aquat Toxicol 100(2):140–150. https://doi.org/10.1016/j.aquatox.2010.07.016
Miller MR, Raftis JB, Langrish JP, McLean SG, Samutrtai P, Connell SP, Wilson S, Vesey AT, Fokkens PHB, Boere AJF, Krystek P, Campbell CJ, Hadoke PWF, Donaldson K, Cassee FR, Newby DE, Duffin R, Mills NL (2017) Inhaled nanoparticles accumulate at sites of vascular disease. ACS Nano 11(5):4542–4552. https://doi.org/10.1021/acsnano.6b08551
Mitchell LA, Lauer FT, Burchiel SW, McDonald JD (2009) Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice. Nat Nanotechnol 4(7):451–456. https://doi.org/10.1038/nnano.2009.151
Mo Y, Lim LY (2005) Paclitaxel-loaded PLGA nanoparticles: potentiation of anticancer activity by surface conjugation with wheat germ agglutinin. J Control Release 108(2–3):244–262. https://doi.org/10.1016/j.jconrel.2005.08.013
Moon J, Kwak JI, Kim SW, An YJ (2017) Multigenerational effects of gold nanoparticles in Caenorhabditis elegans: continuous versus intermittent exposures. Environ Pollut 220(Pt A):46–52. https://doi.org/10.1016/j.envpol.2016.09.021
Newton KM, Puppala HL, Kitchens CL, Colvin VL, Klaine SJ (2013) Silver nanoparticle toxicity to Daphnia magna is a function of dissolved silver concentration. Environ Toxicol Chem 32(10):2356–2364. https://doi.org/10.1002/etc.2300
Ng CT, Yong LQ, Hande MP, Ong CN, Yu LE, Bay BH, Baeg GH (2017) Zinc oxide nanoparticles exhibit cytotoxicity and genotoxicity through oxidative stress responses in human lung fibroblasts and Drosophila melanogaster. Int J Nanomedicine 12:1621–1637. https://doi.org/10.2147/ijn.S124403
Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823–839. https://doi.org/10.1289/ehp.7339
Panacek A, Prucek R, Safarova D, Dittrich M, Richtrova J, Benickova K, Zboril R, Kvitek L (2011) Acute and chronic toxicity effects of silver nanoparticles (NPs) on Drosophila melanogaster. Environ Sci Technol 45(11):4974–4979. https://doi.org/10.1021/es104216b
Patlolla AK, Hussain SM, Schlager JJ, Patlolla S, Tchounwou PB (2010) Comparative study of the clastogenicity of functionalized and nonfunctionalized multiwalled carbon nanotubes in bone marrow cells of Swiss-Webster mice. Environ Toxicol 25(6):608–621. https://doi.org/10.1002/tox.20621
Philbrook NA, Walker VK, Afrooz AR, Saleh NB, Winn LM (2011) Investigating the effects of functionalized carbon nanotubes on reproduction and development in Drosophila melanogaster and CD-1 mice. Reprod Toxicol 32(4):442–448. https://doi.org/10.1016/j.reprotox.2011.09.002
Pietroiusti A, Massimiani M, Fenoglio I, Colonna M, Valentini F, Palleschi G, Camaioni A, Magrini A, Siracusa G, Bergamaschi A, Sgambato A, Campagnolo L (2011) Low doses of pristine and oxidized single-wall carbon nanotubes affect mammalian embryonic development. ACS Nano 5(6):4624–4633. https://doi.org/10.1021/nn200372g
Pluskota A, Horzowski E, Bossinger O, von Mikecz A (2009) In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence. PLoS One 4(8):e6622. https://doi.org/10.1371/journal.pone.0006622
Pompa PP, Vecchio G, Galeone A, Brunetti V, Sabella S, Maiorano G, Falqui A, Bertoni G, Cingolani R (2011) In vivo toxicity assessment of gold nanoparticles in Drosophila melanogaster. Nano Res 4(4):405–413. https://doi.org/10.1007/s12274-011-0095-z
Poon VK, Burd A (2004) In vitro cytotoxity of silver: implication for clinical wound care. Burns 30(2):140–147. https://doi.org/10.1016/j.burns.2003.09.030
Raesian A, Arbabi Bidgoli S, Rezayat Sorkhabadi SM (2017) Dermal toxicity of colloidal nanosilver in albino rabbit: a new approach to physicochemical properties. Nanomed Res J 2(3):142–149. https://doi.org/10.22034/nmrj.2017.03.001
Raj A, Shah P, Agrawal N (2015) Silver nanoparticle affects flying ability of fruit flies. Drosophila Information Service 98(18):9
Raj A, Shah P, Agrawal N (2017a) Dose-dependent effect of silver nanoparticles (AgNPs) on fertility and survival of Drosophila: an in-vivo study. PLoS One 12(5):e0178051. https://doi.org/10.1371/journal.pone.0178051
Raj A, Shah P, Agrawal N (2017b) Sedentary behavior and altered metabolic activity by AgNPs ingestion in Drosophila melanogaster. Sci Rep 7(1):15617. https://doi.org/10.1038/s41598-017-15645-6
Reddy AR, Reddy YN, Krishna DR, Himabindu V (2010) Multi wall carbon nanotubes induce oxidative stress and cytotoxicity in human embryonic kidney (HEK293) cells. Toxicology 272(1–3):11–16. https://doi.org/10.1016/j.tox.2010.03.017
Rehn B, Seiler F, Rehn S, Bruch J, Maier M (2003) Investigations on the inflammatory and genotoxic lung effects of two types of titanium dioxide: untreated and surface treated. Toxicol Appl Pharmacol 189(2):84–95. https://doi.org/10.1016/s0041-008x(03)00092-9
Rim KT, Song SW, Kim HY (2013) Oxidative DNA damage from nanoparticle exposure and its application to workers’ health: a literature review. Saf Health Work 4(4):177–186. https://doi.org/10.1016/j.shaw.2013.07.006
Sarasamma S, Audira G, Juniardi S, Sampurna BP, Lai YH, Hao E, Chen JR, Hsiao CD (2018) Evaluation of the effects of carbon 60 nanoparticle exposure to adult zebrafish: a behavioral and biochemical approach to elucidate the mechanism of toxicity. Int J Mol Sci 19(12):3853. https://doi.org/10.3390/ijms19123853
Scharf A, Piechulek A, von Mikecz A (2013) Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans. ACS Nano 7(12):10695–10703. https://doi.org/10.1021/nn403443r
Schipper ML, Nakayama-Ratchford N, Davis CR, Kam NW, Chu P, Liu Z, Sun X, Dai H, Gambhir SS (2008) A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice. Nat Nanotechnol 3(4):216–221. https://doi.org/10.1038/nnano.2008.68
Seitz F, Bundschuh M, Rosenfeldt RR, Schulz R (2013) Nanoparticle toxicity in Daphnia magna reproduction studies: the importance of test design. Aquat Toxicol 126:163–168. https://doi.org/10.1016/j.aquatox.2012.10.015
Sheng L, Wang L, Su M, Zhao X, Hu R, Yu X, Hong J, Liu D, Xu B, Zhu Y, Wang H, Hong F (2016) Mechanism of TiO2 nanoparticle-induced neurotoxicity in zebrafish (Danio rerio). Environ Toxicol 31(2):163–175. https://doi.org/10.1002/tox.22031
Sondi I, Salopek-Sondi B (2004) Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for gram-negative bacteria. J Colloid Interface Sci 275(1):177–182. https://doi.org/10.1016/j.jcis.2004.02.012
Stoehr LC, Gonzalez E, Stampfl A, Casals E, Duschl A, Puntes V, Oostingh GJ (2011) Shape matters: effects of silver nanospheres and wires on human alveolar epithelial cells. Part Fibre Toxicol 8:36. https://doi.org/10.1186/1743-8977-8-36
Sun L, Li Y, Liu X, Jin M, Zhang L, Du Z, Guo C, Huang P, Sun Z (2011) Cytotoxicity and mitochondrial damage caused by silica nanoparticles. Toxicol In Vitro 25(8):1619–1629. https://doi.org/10.1016/j.tiv.2011.06.012
Sung JH, Ji JH, Yoon JU, Kim DS, Song MY, Jeong J, Han BS, Han JH, Chung YH, Kim J, Kim TS, Chang HK, Lee EJ, Lee JH, Yu IJ (2008) Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles. Inhal Toxicol 20(6):567–574. https://doi.org/10.1080/08958370701874671
Sutunkova MP, Solovyeva SN, Minigalieva IA, Gurvich VB, Valamina IE, Makeyev OH, Shur VY, Shishkina EV, Zubarev IV, Saatkhudinova RR, Klinova SV, Tsaregorodtseva АE, Korotkov AV, Shuman E, Privalova LI, Katsnelson BA (2019) Toxic effects of low-level long-term inhalation exposures of rats to nickel oxide nanoparticles. Int J Mol Sci 20(7):1778. https://doi.org/10.3390/ijms20071778
Truong L, Tilton SC, Zaikova T, Richman E, Waters KM, Hutchison JE, Tanguay RL (2013) Surface functionalities of gold nanoparticles impact embryonic gene expression responses. Nanotoxicology 7(2):192–201. https://doi.org/10.3109/17435390.2011.648225
Tsuchiya T, Oguri I, Yamakoshi YN, Miyata N (1996) Novel harmful effects of [60]fullerene on mouse embryos in vitro and in vivo. FEBS Lett 393(1):139–145. https://doi.org/10.1016/0014-5793(96)00812-5
Usenko CY, Harper SL, Tanguay RL (2007) In vivo evaluation of carbon fullerene toxicity using embryonic zebrafish. Carbon N Y 45(9):1891–1898. https://doi.org/10.1016/j.carbon.2007.04.021
Vales G, Demir E, Kaya B, Creus A, Marcos R (2013) Genotoxicity of cobalt nanoparticles and ions in Drosophila. Nanotoxicology 7(4):462–468. https://doi.org/10.3109/17435390.2012.689882
van der Zande M, Vandebriel RJ, Van Doren E, Kramer E, Herrera Rivera Z, Serrano-Rojero CS, Gremmer ER, Mast J, Peters RJ, Hollman PC, Hendriksen PJ, Marvin HJ, Peijnenburg AA, Bouwmeester H (2012) Distribution, elimination, and toxicity of silver nanoparticles and silver ions in rats after 28-day oral exposure. ACS Nano 6(8):7427–7442. https://doi.org/10.1021/nn302649p
Vance ME, Kuiken T, Vejerano EP, McGinnis SP, Hochella MF Jr, Rejeski D, Hull MS (2015) Nanotechnology in the real world: redeveloping the nanomaterial consumer products inventory. Beilstein J Nanotechnol 6:1769–1780. https://doi.org/10.3762/bjnano.6.181
Vecchio G (2015) A fruit fly in the nanoworld: once again Drosophila contributes to environment and human health. Nanotoxicology 9(2):135–137. https://doi.org/10.3109/17435390.2014.911985
Vecchio G, Galeone A, Brunetti V, Maiorano G, Rizzello L, Sabella S, Cingolani R, Pompa PP (2012a) Mutagenic effects of gold nanoparticles induce aberrant phenotypes in Drosophila melanogaster. Nanomedicine 8(1):1–7. https://doi.org/10.1016/j.nano.2011.11.001
Vecchio G, Galeone A, Brunetti V, Maiorano G, Sabella S, Cingolani R, Pompa PP (2012b) Concentration-dependent, size-independent toxicity of citrate capped AuNPs in Drosophila melanogaster. PLoS One 7(1):e29980. https://doi.org/10.1371/journal.pone.0029980
Verma SK, Jha E, Panda PK, Mukherjee M, Thirumurugan A, Makkar H, Das B, Parashar SKS, Suar M (2018) Mechanistic insight into ROS and neutral lipid alteration induced toxicity in the human model with fins (Danio rerio) by industrially synthesized titanium dioxide nanoparticles. Toxicol Res (Camb) 7(2):244–257. https://doi.org/10.1039/c7tx00300e
Wang JJ, Sanderson BJ, Wang H (2007) Cytotoxicity and genotoxicity of ultrafine crystalline SiO2 particulate in cultured human lymphoblastoid cells. Environ Mol Mutagen 48(2):151–157. https://doi.org/10.1002/em.20287
Wang X, Yang L, Chen ZG, Shin DM (2008) Application of nanotechnology in cancer therapy and imaging. CA Cancer J Clin 58(2):97–110. https://doi.org/10.3322/CA.2007.0003
Wang J, Sun P, Bao Y, Liu J, An L (2011) Cytotoxicity of single-walled carbon nanotubes on PC12 cells. Toxicol In Vitro 25(1):242–250. https://doi.org/10.1016/j.tiv.2010.11.010
Wang B, Chen N, Wei Y, Li J, Sun L, Wu J, Huang Q, Liu C, Fan C, Song H (2012) Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila. Sci Rep 2:563. https://doi.org/10.1038/srep00563
Wang M, Lai X, Shao L, Li L (2018) Evaluation of immunoresponses and cytotoxicity from skin exposure to metallic nanoparticles. Int J Nanomedicine 13:4445–4459. https://doi.org/10.2147/ijn.S170745
Weber K, Razinger T, Hardisty JF, Mann P, Martel KC, Frische EA, Blumbach K, Hillen S, Song S, Anzai T, Chevalier HJ (2011) Differences in rat models used in routine toxicity studies. Int J Toxicol 30(2):162–173. https://doi.org/10.1177/1091581810391818
Wen H, Dan M, Yang Y, Lyu J, Shao A, Cheng X, Chen L, Xu L (2017) Acute toxicity and genotoxicity of silver nanoparticle in rats. PLoS One 12(9):e0185554. https://doi.org/10.1371/journal.pone.0185554
Wilhelmi V, Fischer U, van Berlo D, Schulze-Osthoff K, Schins RP, Albrecht C (2012) Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicol In Vitro 26(2):323–334. https://doi.org/10.1016/j.tiv.2011.12.006
Wu M, Huang S (2017) Magnetic nanoparticles in cancer diagnosis, drug delivery and treatment. Mol Clin Oncol 7(5):738–746. https://doi.org/10.3892/mco.2017.1399
Wu J, Liu W, Xue C, Zhou S, Lan F, Bi L, Xu H, Yang X, Zeng FD (2009) Toxicity and penetration of TiO2 nanoparticles in hairless mice and porcine skin after subchronic dermal exposure. Toxicol Lett 191(1):1–8. https://doi.org/10.1016/j.toxlet.2009.05.020
Xiao Y, Vijver MG, Chen G, Peijnenburg WJ (2015) Toxicity and accumulation of Cu and ZnO nanoparticles in Daphnia magna. Environ Sci Technol 49(7):4657–4664. https://doi.org/10.1021/acs.est.5b00538
Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR (2008) Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes. Sensors (Basel) 8(1):488–499. https://doi.org/10.3390/s8010488
Zhao X, Ze Y, Gao G, Sang X, Li B, Gui S, Sheng L, Sun Q, Cheng J, Cheng Z, Hu R, Wang L, Hong F (2013) Nanosized TiO2-induced reproductive system dysfunction and its mechanism in female mice. PLoS One 8(4):e59378. https://doi.org/10.1371/journal.pone.0059378
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Raj, A., Shah, P., Agrawal, N. (2020). Model Organisms for In Vivo Assessment of Nanoparticles. In: Agrawal, N., Shah, P. (eds) Toxicology of Nanoparticles: Insights from Drosophila. Springer, Singapore. https://doi.org/10.1007/978-981-15-5522-0_2
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