Abstract
Pleomorphic xanthoastrocytoma is a rare glial tumor that often arises from the temporal lobe of young adults. This is considered a low-grade tumor but has an aggressive variant which may arise de novo or after progression from grade II tumors. Surgery is the cornerstone of therapy and confers survival advantage when a GTR is accomplished. Adjuvant radiation therapy is advocated in higher grade tumor or in salvage setting. Recent molecular studies have identified BRAF mutation in nearly 60% patients and BRAF inhibitors are in use with promising results in a subset of patients.
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Mallick, S., Anjali, V.R. (2021). Pleomorphic Xanthoastrocytoma. In: Mallick, S., Giridhar, P., Rath, G.K. (eds) Evidence based practice in Neuro-oncology. Springer, Singapore. https://doi.org/10.1007/978-981-16-2659-3_19
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DOI: https://doi.org/10.1007/978-981-16-2659-3_19
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