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Overview of Living Cell Delivery Method Based on Biological Probe

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Proceedings of the Eighth Asia International Symposium on Mechatronics

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 885))

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Abstract

Intracellular delivery strategies are critical to the application of gene delivery, cell therapy, induced pluripotent stem cells, etc. Traditional methods such as viruses, liposomes, and electroporation always lead to high toxicity and cell damage, therefore, their applications can be limited. The mechanical method based on biological probes is less harmful to cells and keep the cell activities. Molecules can be delivered into the living cell quite accurately as well. So, the mechanical method is getting more and more attention. Biological probes methods include microinjection, nanotips and nanoneedle array, the following overview introduces the characteristics and applications of these three methods. In the end, we compared the advantages and disadvantages of these three methods and we make the prospects for subsequent development.

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Acknowledgements

The authors would like to acknowledge financial support from the Natural Science Foundation of China (52005084, 51975107), Fundamental Research Funds for the Central Universities (No. ZYGX2019J037).

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Authors and Affiliations

  1. School of Mechanical and Electrical Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan, 611731, People’s Republic of China

    Na Fan, Jie Zou, Gangfei Feng & Bei Peng

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  1. Na Fan
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  2. Jie Zou
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  3. Gangfei Feng
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  4. Bei Peng
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Correspondence to Bei Peng .

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Editors and Affiliations

  1. Xidian University, Xi'an, Shaanxi, China

    Baoyan Duan

  2. Department of Precision Mechanics, Chuo University, Tokyo, Tokyo, Japan

    Kazunori Umeda

  3. Konkuk University, Seoul, Korea (Republic of)

    Chang-wan Kim

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Fan, N., Zou, J., Feng, G., Peng, B. (2022). Overview of Living Cell Delivery Method Based on Biological Probe. In: Duan, B., Umeda, K., Kim, Cw. (eds) Proceedings of the Eighth Asia International Symposium on Mechatronics. Lecture Notes in Electrical Engineering, vol 885. Springer, Singapore. https://doi.org/10.1007/978-981-19-1309-9_192

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