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Today’s carcinochemotherapy: Some of its achievements, failures and prospects

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References

  • Adamson, R. H., Fabro, S.: Some studies with asparaginase, asparagine and asparagine analogues. Proc. Amer. Ass. Cancer Res. 9, 2 (3) (1968).

    Google Scholar 

  • — —Antitumor activity and other biological property of l-asparaginase. A review. Cancer Chemother. Rep. 52, 617–626 (1968).

    PubMed  CAS  Google Scholar 

  • Alarcon, R. A.: Isolation of acrolein from mixtures of spermine with calf serum and its effects on mammalian cells. Arch. Biochem. 106, 240–242 (1964).

    Article  PubMed  CAS  Google Scholar 

  • — Acrolein II. Studies on the fluorescence produced by acrolein, spermine and related compounds with resorcinol and calf serum. Arch. Biochem. 113, 281–287 (1966).

    Article  PubMed  CAS  Google Scholar 

  • — Fluorometric determination of acrolein and related compounds with m-aminophenol. Analyt. Chem. 40, 1704–1708 (1968).

    Article  CAS  Google Scholar 

  • Alexander, P.: Immunotherapy of leukemia. The use of different classes of immune lymphocytes. Cancer Res. 27, 2521–2526 (1967).

    PubMed  CAS  Google Scholar 

  • — Immunotherapy of cancer. Experiments with primary tumours and syngeneic tumour grafts. In: Progr. Exp. Tumor Res. (Basel) 10, 22–71 (1968a).

    Google Scholar 

  • — Treatment of experimental tumours with immune lymphocytes. In: Proc. Int. Symp. on Gammapathies, Infections, Cancer and Immunity, p. 81–83 (V. Chini, S. Bonomo and C. Sirtori, eds.), 1968b.

    Google Scholar 

  • — Hamilton Fairley, G.: Cellular resistance to tumours. Brit. med. Bull. 23, 86–92 (1967).

    PubMed  CAS  Google Scholar 

  • Anglesio, E.: The treatment of Hodgkin’s disease. In: Recent results in cancer research, vol. 18, p. 30–42. Berlin-Heidelberg-New York: Springer 1969.

    Google Scholar 

  • Bahnson, C. G.: Chm., Second Conference on Psychophysiological Aspects of Cancer May 1968. Ann. N.Y. Acad. Sci. in press (1969).

    Google Scholar 

  • Banks, B. E. C., Banthorpe, D. V., Berry, D. V., Davies, H. ff. S., Doonan, S., Lamont, D. M., Shipolini, R., Vernon, C. A.: The preparation of nerve growth factors from snake venoms. Biochem. J. 108, 157–158 (1968).

    PubMed  CAS  Google Scholar 

  • Bardos, T. J., Gordon, H. L., Chmielewicz, Z. F., Kutz, R. L., Ambrus, J. L.: Screening of animal tissues for inhibitory substances. Abstr. Papers, SO 596, IXth Int. Cancer Congr., Tokyo 1966.

    Google Scholar 

  • — — — — —Systemic investigations of the presence of growth inhibitory substances in animal tissues. Cancer Res. 28, 1620–1630 (1968).

    PubMed  CAS  Google Scholar 

  • Barry, V. C., Conalty, M. L., O’Callaghan, C. N., Twomey, D.: Anticancer agents III. Synthesis and anticancer activity of some bisthiosemicarbazones and thiosemicarbazones. Proc. roy. Irish Acad. B 65, 309–324 (1967).

    CAS  Google Scholar 

  • — — McCormick, J. E., McElhinney, R. S., McInerney, M. R., O’sullivan, J. F.: Anticancer agents. I. Structure-activity relationships in a series of oxypolysaccharide-thiosemicarbazide derivatives. Proc. roy. Irish Acad. B 64, 335–354 (1966).

    CAS  Google Scholar 

  • — — — — — — Twomey, D.: The relationship of chemical structure to anti-cancer activity in substituted thiosemicarbazide derivatives of dicarbonyl compounds. Abstr. Papers SO 550, IXth Int. Cancer Congr., Tokyo 1966.

    Google Scholar 

  • — — O’sullivan, J. F.: Anticancer activity of bisthiosemicarbazones of methylglyoxal. Cancer Res. 26, 2165–2168 (1966).

    PubMed  CAS  Google Scholar 

  • Bergel, F.: Chemistry of enzymes in cancer. Springfield (Ill.): Ch. C. Thomas 1961.

    Google Scholar 

  • — Development, possibilities and prospects of alkylating agents in chemotherapy of cancer (ed. P. A. Plattner), p. 21–31. Amsterdam: Elsevier Publ. Co. 1964a.

    Google Scholar 

  • — Optical stereospecificity of anti-cancer agents. Farmaco 19, 99–109 (1964b).

    CAS  Google Scholar 

  • — Whence and whither chemotherapy. Proc. roy. Instn. 40, 355–374 (1965).

    Google Scholar 

  • — Zusammenfassung und Ausblick. In: Molekulare Biologie des Malignen Wachstums. Berlin-Heidelberg-New York: Springer 1966a.

    Google Scholar 

  • — In place of experimental animals. New Scientist, 9th June, 646–647 (1966b).

    Google Scholar 

  • — Current advances in cancer research. Nursing Times, London, December 1967.

    Google Scholar 

  • — Harrap, K. R.: Future possibilities for the development of treatments in leukemia. Cancer Res. 25, 1643–1648 (1965).

    PubMed  CAS  Google Scholar 

  • — — Scott, A. M.: Interaction between carbonyl groups and biologically essential substituents, part IV. An enzyme model system for cysteine desulphydrase. J. chem. Soc. 1101–1112 (1962).

    Google Scholar 

  • — Johnson, J. M., Wade, R.: Antitumour activity of a series of acetyldipeptide esters containing melphalan, p. 241–245. In: Proc. 6th Europ. Symp., Athens, Pergamon Press., London 1965.

    Google Scholar 

  • Best, C. H., Taylor, N. B.: The physiological basis of medical practice. 4th ed. London: Baillière, Tindall & Cox 1945.

    Google Scholar 

  • Boesen, F., Davis, W.: Cytotoxic drugs in the treatment of cancer. London: Edward Arnold 1969.

    Google Scholar 

  • Boyland, F.: Hormone withdrawal in the treatment of cancer. Cancer Chemother. Rep. 13, 7–8 (1961).

    Google Scholar 

  • Bratzel, R. P., Ross, R. B., Goodridge, T. H., Huntress, W. T., Flather, M. T., Johnson, D. E.: A survey of alkylating agents. Cancer Chemother. Rep. 26, 1–506 (1963).

    PubMed  CAS  Google Scholar 

  • British Association for cancer research, Autumn Mtg., Symposium on Aetiological Factors in Lymphomas, Sept. 1968.

    Google Scholar 

  • — — — — — The Rationale and Assessment of Cancer Chemotherapy, Owen’s Park, Manchester, April 1969.

    Google Scholar 

  • Brockmann, H.: Die Actinomycine. Fortschr. Chem. org. Naturstoffe 18, 1–54 (1960).

    CAS  Google Scholar 

  • Brockman, R. W.: Resistance to purine antagonists in experimental leukemia systems. Cancer Res. 25, 1596–1607 (1965).

    PubMed  CAS  Google Scholar 

  • Brookes, P.: Reaction of alkylating agents with nucleic acids. In: Chemotherapy of cancer (P. A. Plattner, ed.), p. 32–43. Amsterdam: Elsevier Publ. Co. 1964.

    Google Scholar 

  • Broome, J. D.: Evidence that the l-asparaginase activity of guinea pig serum is responsible for its antilymphoma effects. Nature (London) 191, 1114 (1961).

    Article  CAS  Google Scholar 

  • — Evidence that l-asparaginase of guinea pig serum is responsible for its antilymphoma effect. J. exp. Med. 118, 99–120, 121–148 (1963).

    Article  PubMed  CAS  Google Scholar 

  • — Antilymphoma activity of l-asparaginase in vivo; clearance rates of enzyme preparations from guinea pig serum and yeast in relation to their effect on tumor growth. J. nat. Cancer Inst. 35, 967–974 (1965).

    PubMed  CAS  Google Scholar 

  • — Studies on the tumor inhibitory action of l-asparaginase. Abstr. Papers, SO 584, IXth Int. Cancer Congr., Tokyo 1966.

    Google Scholar 

  • — Mechanism of action of l-asparaginase. Proc. Conf. on l-Asparaginase, New Brunswick, N. J., 14th March 1968a.

    Google Scholar 

  • l-asparaginase: The evolution of a new tumor inhibitory agent. N. Y. Acad, Scie., Ser. II, 30, 690–704 (1968b).

    CAS  Google Scholar 

  • — Private Communication 1969. See also l-asparaginase, presented in: Z. B. Papanastassiou, Memorial Symposium on Current Trends in Cancer Chemotherapy. Med. Chem. Group, N. E. Section, Am. Chem. Soc. May 1969.

    Google Scholar 

  • Bullough, W. S.: Mitotic and functional homeostasis. Cancer Res. 25, 1683–1727 (1965).

    PubMed  CAS  Google Scholar 

  • — Laurence, E. B.: Epidermal chalone and mitotic control in the Vx 2 epidermal tumour. Nature (Lond.) 220, 134–135 (1968a).

    Article  CAS  Google Scholar 

  • — —Control of mitosis in rabbit Vx 2 epidermal tumour by means of the epidermal chalone. Europ. J. Cancer. 4, 587–594 (1968b).

    CAS  Google Scholar 

  • — —Melanocyte chalone and mitotic control in melanomata. Nature (Lond.) 220, 137–138 (1968c).

    Article  CAS  Google Scholar 

  • — —Control of mitosis in mouse and hamster melanomata by means of melanocyte chalone. Europ. J. Cancer 4, 607–615 (1968d).

    CAS  Google Scholar 

  • Burke, D. C.: Interferon — Some aspects of production and action. In: Symposium on Drugs, Parasites and Hosts (ed. L. G. Goodwin and R. H. Nimmo-Smith), p. 294–319. London: J. & A. Churchill 1962.

    Google Scholar 

  • Burke, P. F., Lenhard, R. E., Jr., Owens, A. H. Jr.: Therapy for acute leukemia in adults with cytosine arabinoside, vincristine and prednisone. Cancer Chemother. Rep. 52, 305–314 (1968).

    PubMed  CAS  Google Scholar 

  • Calvert, N., Connors, T. A., Ross, W. C. J.: Aryl-2-halogenalkylamines XXV. Derivatives of sulphonamide designed for selective deposition in neoplastic tissue. J. Europ. J. Cancer 4, 627–636 (1968).

    CAS  Google Scholar 

  • Cannon, W. B.: Organization for physiological homeostasis. Physiol. Rev. 9, 399–431 (1929).

    Google Scholar 

  • — Wisdom of the body. New York: W. W. Norton 1932.

    Google Scholar 

  • Carter, S. K.: Streptonigrin. Chemother. Sheet. Nat. Cancer Inst., Nov. 1968.

    Google Scholar 

  • Clayson, D. B.: Chemical carcinogenesis. Hormones and related compounds, p. 315–371. Hormonal therapy, p. 407. London: J. & A. Churchill, Ltd. 1962.

    Google Scholar 

  • Cobb, L. M., Connors, T. A., Elson, L. A., Khan, A. H.: 2,4-Dinitro-5-Ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256. Biochem. Pharmacol. 18, 1519–1527 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Connors, T. A., Elson, L. A., Haddow, H., Ross, W. C. J.: The pharmacology and tumour growth inhibitory activity of 1-aminocyclopentane-1-carboxylic acid. Biochem. Pharmacol. 5, 108–129 (1960).

    Article  PubMed  CAS  Google Scholar 

  • — Whisson, M. E.: Cure of mice bearing advanced plasma cell tumours with aniline mustard. Nature (Lond.) 210, 866–867 (1966).

    Article  CAS  Google Scholar 

  • Creighton, A. M., Hellmann, K., Whitecross, S.: Antitumour activity in a series of bisDiketopiperazines. Nature (Lond.) 222, 384–385 (1969).

    Article  CAS  Google Scholar 

  • Davis, W.: Secr., A. Llombart, Hon. Chm. and the Co-ordinating Committee for Human Tumour Investigations. 3rd Int. Symp. on the Biol. Charact. of Hum. Tumrs., Madrid, April 1969.

    Google Scholar 

  • Day, E. D.: The Immunochemistry of cancer. Amer. Lect. Ser. Springfield (Ill.): Ch. C. Thomas 1965.

    Google Scholar 

  • De Duve, C.: Lysosomes as targets for drugs. In: the Symposium on the Interaction of Drugs and Subcellular Components in Animal Cells (ed. D. C. Campbell), p. 155–169. London: J. & A. Churchill, Ltd. 1968.

    Google Scholar 

  • Delorme, E. J., Alexander, P.: Treatment of primary fibrosarcoma in the rat with immune lymphocytes. Lancet 1964II, 117–120.

    Google Scholar 

  • Connel, D. I., Mikulska, Z. B., Alexander, P.: Immunological procedures for treating primary chemically induced fibrosarcoma in the rat and a murine-leukemia. In: Symposium on Specific Tumour Antigens (ed. R. J. C. Harris), p. 108–203. U.I.C.C. Monograph No 2, 1967.

    Google Scholar 

  • De Reuck, A. V. S., Knight, J., eds.: Ciba Foundation Symposium on Cell Differentiation. London: J. & A. Churchill, Ltd. 1967.

    Google Scholar 

  • Dewys, W. D., Humphreys, S. R., Goldin, A.: Studies on therapeutic effectiveness of drugs, etc. Cancer Chemother. Rep. 52, 229–242 (1968).

    PubMed  CAS  Google Scholar 

  • Djerassi, I., Farber, S.: Control and prevention of hemorrhage; platelet transfusion. Cancer Res. 25, 1499–1503 (1965).

    PubMed  CAS  Google Scholar 

  • Druckrey, H., Pressmann, R., Ivankovicz, S., Schmähl, K.: Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten. Z. Krebsforsch. 69, 103–201 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Elion, G. B., Nathan, H., Bieber, S., Rundles, R. W., Hitchings, G. H.: Potentiation by inhibition of drug degradation: 6-substituted purines and xanthine oxidase. Biochem. Pharmacol. 12, 86–93 (1963). See also Symposium on Allopurinol (ed. J. T. Scott). Ann. rheum. Dis. 25, No 6 (Suppl.), 599–718 (1966).

    Article  Google Scholar 

  • Elson, L. A., Jarman, M., Ross, W. C. J.: Toxicity, haematological effects and antitumour activity of epoxides derived from disubstituted hexitols. Mode of action of mannitol myleran and dibromomannitol. Europ. J. Cancer 4, 617–625 (1968).

    CAS  Google Scholar 

  • Endicott, K. M.: U.S. strategy against cancer. New Scientist 856–867 (Sept. 1965).

    Google Scholar 

  • Farber, S.: Clinical and biological studies with actinomycin. In: Amino Acids and Peptides. Ciba Foundation Symposium (eds. G. E. W. Wolstenholme and C. M. O’Connor), p. 138–148. London: J. & A. Churchill Ltd. 1958.

    Google Scholar 

  • — Remarks during symposium on obstacles to the control of acute leukemia. Cancer Res. 25, 1472 and at closing session (1965).

    Google Scholar 

  • — Chemotherapy in the treatment of leukemia and Wilm’s tumor. J. Amer. med. Ass. 198, 826–836 (1966).

    Article  CAS  Google Scholar 

  • — Concluding remarks in symposium on acute leukemia and Burkitt’s tumor. Cancer Res. 27, 2658–2660 (1967).

    PubMed  CAS  Google Scholar 

  • Mitus, A. T.: Role of actinomycin D (Dactinomycin). Pediatric oncology. In: Actinomycin (ed. S. A. Waksman), p. 137–145. New York: Intersc. Publ. 1968.

    Google Scholar 

  • Foley, G. E., Barell, E. F., Adams, R. A., Lazarus, H.: Nutritional requirements of human leukemic cells: cystine requirements of diploid cell lines and their heteroploid variants. J. exp. Cell Res. 57, 129–133 (1969).

    Article  CAS  Google Scholar 

  • Fox, B. W.: The sensitivity of Yoshida sarcoma to methylene dimethanesulphonate. Int. J. Cancer 4, 54–60 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Jackson, H.: In vivo effects of methylene dimethane sulphonate in proliferating cell systems. Brit. J. Pharmacol. 24, 24–28 (1965).

    PubMed  CAS  Google Scholar 

  • Freeman, R. G., Knox, J. M.: Treatment of skin cancer. In: Recent results in cancer research, vol. 11, p. 19ff. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  • Frei III, E.: Summary of informal discussion on clinical obstacles to the control of acute leukemia. Cancer Res. 25, 1570 (1965).

    Google Scholar 

  • Frei III, E.: New agents and combination therapy. In: Z. B. Papanastassiou Memorial Symposium on Current Trends in Cancer Chemotherapy. Med. Chem. Group, N. F. Section, Amer. Chem. Soc., May 1969.

    Google Scholar 

  • French, F. A., Freedlander, B. L.: Chemotherapy studies on transplanted mouse tumors. Cancer Res. 20, 505–538 (1960).

    CAS  Google Scholar 

  • Fullerton, W. W., Boggust, W. A., O’Meara, R. A. Q.: Antithromboplastic activities of fatty acids. J. clin. Path. 20, 624–628 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Garattini, S., Connors, T. A., Albert, A.: Training course in cancer chemotherapy, Comm. on. Exp. Chemother. of the Comm. on Exptl. Oncol., U.I.C.C. in conj. with Polish Acad. Sciences, Warsaw, Okt. 1968a.

    Google Scholar 

  • Amos, D. B., Goldin, A., Milder, J., Rall, D. P., Mandel, H. G.: Conference on the Critical Evaluation of Cancer Chemotherapy. Cherry Hill, New Jersey, April 1969.

    Google Scholar 

  • Donelli, M. G., Morasca, L., Rainisio, C., Rosso, R.: Attempts to establish new experimental methods to study antitumural drugs. Acta Genet. med. (Roma) 17, 60–66 (1968b).

    Google Scholar 

  • Gericke, D.: DL-Glycerinaldehyd eine cytostatische Substanz? Krebsforschungslabor Farbwerke Hoechst. Abstr. 577, Int. Chemother. Kongr. Wien: Med. Acad. 1967.

    Google Scholar 

  • — Aspekte der Immuntherapy Maligner Tumoren. Med. Klin. 63, 1143–1146 (1968).

    PubMed  CAS  Google Scholar 

  • Contzen, H.: Weitere Untersuchungen zur Onkolyse. Abstr. 1081 Int. Chemother. Kongr. Wien: Med. Akad. 1967.

    Google Scholar 

  • Engelbert, K.: Onkolysis by Clostridia II. Experiments on a variety of Clostridia in combination with heavy metal. Cancer Res. 24, 217–221, see parts I, III, etc. same volume (1964).

    PubMed  CAS  Google Scholar 

  • Schütze. E.: Versuche zur Beeinflussung des Tumorenwachstums durch Mykoplasmen. Zbl. Bakt., I. Abt. Orig. 210, 212–216 (1969).

    CAS  Google Scholar 

  • Gold, P.: Tumor-specific antibody production in digestive system of cancer patients. Symposium on Immunological Aspects of Malignant Disease, 59th Ann. Mtg. Amer. Ass. Cancer Res. Atlantic City, N. J., 12th April 1968.

    Google Scholar 

  • Goldenberg, I. S., Morin, J. E., Cahow, C. E.: Hormonal therapy for metastatic breast carcinoma in women VII. 6α-chloro-16α-methylpregn-4-ene-3,20-dione. Cancer Chemother. Rep. 50, 327–329 (1966).

    Google Scholar 

  • Goldin, A., Kaziwara, K., Kinosita, R., Yamamura, Y. (eds.): Cancer Chemotherapy. Jap. Cancer Ass., Gann Monograph 2, Tokyo: Maruzen Co. Ltd. (1967).

    Google Scholar 

  • Serpick, A. A., Mantel, N.: Experimental screening procedures and clinical predictability value. Cancer Chemother. Rep. 50, 173–218 (1966).

    PubMed  CAS  Google Scholar 

  • Wood, H. B., Jr., Engle, R. R.: Relation of structure of purine and pyrimidine nucleosides to antitumor activity. Cancer Chemother. Rep. (Suppl.) 1, 1–268 (1968).

    CAS  Google Scholar 

  • Gorer, P. A.: Isoantigens of malignant cells. In: Biol. appr. to cancer chemother. (ed. R. C. J. Harris), p. 219–230. London: Academic Press 1961.

    Google Scholar 

  • Greenwald, E. S.: Cancer chemotherapy. London: Heinemann 1967.

    Google Scholar 

  • Haddow, A.: Tumour immunology. Brit. med. Bull. 21, 133–139 (1965).

    PubMed  CAS  Google Scholar 

  • Alexander, P.: An immunological method of increasing the sensitivity of primary sarcomas to local irradiation with X-rays. Lancet 1964I, 452–457.

    Google Scholar 

  • Hall, T. C. (in place of S. Farber): Member of the cancer chemotherapy panel. Abstr. of Papers 12, IXth Int. Cancer Congr. Tokyo 1966.

    Google Scholar 

  • Kessel, D., Godsill, A., Roberts, D.: Uridine phosphorylation, an overlooked pathway?; 5-fluorouridine, a neglected drug? Proc. Amer. Ass. Cancer Res. 9, 27, 103 (1968).

    Google Scholar 

  • Hamilton Fairley, G., Simister, J. M., eds.: Cyclophosphamide. Bristol: J. Wright & Sons, Ltd. 1964.

    Google Scholar 

  • Hancock, P. E. T.: T. Hodgkin. The Fitz Patrick Lecture. J. roy. Coll. Phycns (Lond.) 2, 404–421 (1968).

    Google Scholar 

  • Handschuhmacher, R. E.: Discussion remark (not recorded) during Symposium of Amer. Cancer Soc., Conference on Obstacles to the Control of Acute Leukemia 1965.

    Google Scholar 

  • Harrap, K. R., Jackson, R. C.: Some biochemical aspects of leukaemias; leucocyte glutathione metabolism in chronic granulocytic leukemia. Europ. J. Cancer 5, 61–67 (1969).

    CAS  Google Scholar 

  • Harris, R. J. C., ed.: Proc. IXth. Int. Cancer Congr., UICC Monograph Ser. Panel 4. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  • Hartmann, J. R., Chm: Clinical study of fluorometholone in acute leukemia in children. Cancer Chemother. Rep. 50, 339–345 (1966).

    Google Scholar 

  • Heidelberger, C.: Fluorinated pyrimidines — biochemically and clinically useful anti-metabolites. In: Molekulare Biologie des malignen Wachstums, p. 156–176 (Holzer and Holldorf, eds.). Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Hellman, K.: Org., Symposium on Experimental Aspects of Cancer Chemotherapy (tape recordings). Imperial Cancer Res. Fund, London 1968.

    Google Scholar 

  • Hertz, R., Lewis, J., Lipsett, M. B.: Five years’ experience with chemotherapy of metastatic choriocarcinoma and related trophoblastic tumors in women. Amer. J. Obstet. Gynaecol. 82, 631–640 (1961).

    CAS  Google Scholar 

  • Hill, J. M., Roberts, J., Loeb, E., Khan, A., McLellan, A., Hill, R. W.: l-Aspararaginase therapy for leukemia and malignant neoplasms. J. Amer. Med. Assoc. 202, 882–888 (1967).

    Article  CAS  Google Scholar 

  • Hoelzel, F., Hebbelin, H., Hoecke, E., Maas, H.: Die Penetration und die intrazelluläre Verteilung von Trenimon, p-Benzochinon, Actinomycin und TEM bei in vitro-Untersuchungen mit Ehrlich Ascitestumor Zellen. Z. Krebsforsch. 70, 74–94 (1968).

    Google Scholar 

  • Holzer, H.: Wirkungsmechanismus der Zytostatika. Dtsch. med. J. 12, 312–317 (1961).

    PubMed  CAS  Google Scholar 

  • — Intrazelluläre Regulation des Stoffwechsels. Naturwissenschaften 50, 260–269 (1963); see also: Diskussion (Leitung: H. Holzer). In: Molekulare Biologie des malignen Wachstums, p. 74–78. Berlin-Heidelberg-New York: Springer 1964.

    Article  CAS  Google Scholar 

  • Hondius Boldingh, W., Laurence, E. B.: Extraction, purification and preliminary characterisation of the epidermal chalone: a tissue specific mitotic inhibitor obtained from vertebrate skin. Europ. J. Biochem. 5, 191 (1968).

    Article  CAS  Google Scholar 

  • Horowitz, B., Madras, B., Meister, A., Old, L. J., Old, E. A.: l-Asparagine synthetase activities of mouse leukemias. Proc. Amer. Ass. Cancer Res. 9, 33, 127 (1968).

    Google Scholar 

  • Hórvath, I. P., Institoris, L.: Influence of the chemical structure on the biological tendency of cytostatic compounds related to dibromomannitol. Arzneimittel-Forsch. 17, 149–155 (1967).

    Google Scholar 

  • Howard, J. P., Cevik, N., Murphy, M. L.: Cytosine arabinoside in acute leukemia in children. Cancer Chemother. Rep. 50, 287–291 (1966).

    PubMed  CAS  Google Scholar 

  • Israel, M., Maddock, C. L., Modest, E. J.: Experimental antitumor activity of synthetic polyamines. Abstr. Papers, SO 555, p. 320. IXth Int. Cancer Congr. Tokyo 1966.

    Google Scholar 

  • Iversen, O. H.: Chalones of the skin. In: Joint Symposium Ciba Foundation and Wellcome Trust on Homeostatic Regulators, p. 29–56. London: J. & A. Churchill, Ltd. 1969.

    Chapter  Google Scholar 

  • Jaques, P. J.: Lysosomes and homeostatic regulation. In: Joint Ciba Foundation and Wellcome Trust Symposium on Homeostatic Regulators (eds. G. E. W. Wolstenholme and J. Knight), p. 180–196. London: J. & A. Churchill, Ltd. 1969.

    Chapter  Google Scholar 

  • Jarman, M., Ross, W. C. J.: The formation of epoxides from substituted hexitols. Carbohydr. Res. 9, 1 139–147 (1969a).

    Article  CAS  Google Scholar 

  • — — 4-substituted nicotinic acids and nicotinamides. Pt. II. The preparation of 4-methylnicotinamide riboside. J. chem. Soc. 199–203 (1969b).

    Google Scholar 

  • Johnson, J. M., Bergel, F.: Biological alkylating agents. In: Hochster and Quastel (eds.), Metabolic inhibitors, vol. II, p. 161–192. New York: Academic Press 1963.

    Google Scholar 

  • Johnson, R. O., Bisel, H., Andrews, N., Wilson, W., and others: Phase I clinical study of 6α-methylpregn-4-ene-3,11,20-trione. Cancer Chemother. Rep. 50, 671–673 (1966).

    Google Scholar 

  • Kaung, D. T., Walsh, W. S., Sbar, S., Patno, M. E.: Hydroxyureas in therapy for nonresectable cancer of the lung. Cancer Chemother. Rep. 52, 271–274 (1968).

    PubMed  CAS  Google Scholar 

  • Keast, D., Grieve, G. M., Stanley, N. F.: Chemotherapy of reovirus-induced murine lymphoma 2731/L. Cancer in Africa 23, 1 (1968).

    Google Scholar 

  • Kennedy, B. J.: Effect of massive doses of estradiol. undecylate in advanced breast cancer. Cancer Chemother. Rep. 51, 491–495 (1967).

    Google Scholar 

  • Kessel, D., Hall, T. C., Rosenthal, D.: Uptake and phosphorylation of cytosine arabinoside by normal human blood cells in vitro. Cancer Res. 29, 459–463 (1969).

    PubMed  CAS  Google Scholar 

  • Klein, E., Farber, S., Djerassi, I.: Control and prevention of hemorrhage; platelet separation. Cancer Res. 25, 1504–1509 (1965).

    PubMed  CAS  Google Scholar 

  • Klein, G., Sjögren, H. O.: Humoral and cellular factors in homograft and isograft immunity against sarcoma cells. Cancer Res. 20, 452–461 (1960).

    PubMed  CAS  Google Scholar 

  • — Discussion remark. In: Symposium on Biological Approaches to Cancer Chemotherapy (ed. R. C. J. Harris), p. 230. London: Academic Press 1961a.

    Google Scholar 

  • — Population changes in drug resistance in tumours. In: Symposium on Biological Approaches to Cancer Chemotherapy (ed. R. C. J. Harris), p. 201–217. London: Academic Press 1961b.

    Google Scholar 

  • — Humoral and cell-mediated mechanisms for host defense in tumor immunity. In: Viruses inducing Cancer, Implication for Therapy (W. J. Burdett, ed.), p. 323–349. Salt Lake City: Univ. of Utah Press 1966.

    Google Scholar 

  • — Klein, E., Clifford, P.: Search for host defences in Burkitt lymphoma: Membrane fluorescence tests on biopsies and tissue culture lines. Cancer Res. 27, 2510–2520 (1967).

    PubMed  CAS  Google Scholar 

  • Kline, I.: Chemotherapy of leukemia L 1210 1-β-D-Arabinofuranosylcytosin Hydrochloride. Cancer Res. 26, 853–859; 1930–1937 (1966).

    PubMed  CAS  Google Scholar 

  • Koldovsky, P.: Tumor specific transplantation antigen. In: Recent result in cancer research, vol. 22. Berlin-Heidelberg-New York: Springer 1969.

    Google Scholar 

  • Krakoff, I. H., Clifford, G. O.: Clinical studies of N-hydroxyurethan. Cancer Chemother. Rep. 52, 635–639 (1968).

    PubMed  CAS  Google Scholar 

  • Larionov, L. F.: Cancer chemotherapy. London and New York: Pergamon Press Ltd., 1965.

    Google Scholar 

  • Law, L. W.: Presidential address, “Studies of the significance of tumor antigens in the induction and repression of neoplastic diseases”. 59th Ann. Mgt. Amer. Ass. Cancer Res. Cancer Res. 29, 1–22 (1969).

    CAS  Google Scholar 

  • Lawley, P. D.: Mechanism of action of alkylating agents: comparison with other cytotoxic, mutagenic and carcinogenic agents. In: Molekulare Biologie des malignen Wachstums, p. 126–141. See also Diskussion ibid., p. 150–155. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Lazarus, H., McCoy, T. A., Farber, S., Foley, G. E.: Nutritional requirements of human leukemic cells. Asparagine requirements and the effects of l-asparaginase. J. exp. Cell Res. 57, 134–138 (1969).

    Article  CAS  Google Scholar 

  • Lefkowitz, E., Papac, R. J., Bertino, J. R.: Head and neck cancer. Cancer Chemother. Rep. 51, 305–311 (1967).

    PubMed  CAS  Google Scholar 

  • Lewerenz, H. J.: Zur Wirkung von DL-Glyceraldehyd auf permanente Kulturen menschlicher Zellen. Z. Krebsforsch. 69, 260–269 (1967).

    Article  PubMed  CAS  Google Scholar 

  • Li, C. P., Prescott, B., Usdin, F., Eddy, B. E., Martino, E. C.: Local chemotherapy of neoplasm in hamsters with clam extract. Abstr. Papers, SO 583, IXth Int. Cancer congr. Tokyo 1966.

    Google Scholar 

  • Liss, E., Palme, G., Oeff, K.: In vivo-Versuche über die Wirkung des Trenimons I. Z. Krebsforsch. 71, 89–98 (1968).

    Article  PubMed  CAS  Google Scholar 

  • Loo, T. L.: Effect of chemotherapy on kinetics of leukemic cells. Cancer Chemother. Rep. 50, 296–297 (1966).

    Google Scholar 

  • Loveless, A.: Possible relevance of O-6 alkylation of deoxyguanosine to the mutagenicity and carcinogenicity of nitrosamines and nitrosamides. Nature (Lond.) 223, 206–207 (1969).

    Article  CAS  Google Scholar 

  • Lovesey, A. C., Ross, W. C. J.: Potential coenzyme inhibitors. Pt. II. Reduction of 4-methylnicotinamide derivatives by sodium dithionate and sodium borohydride. J. chem. Soc. 192–195 (1969).

    Google Scholar 

  • Maeda, H., Kumagai, K., Ishida, N.: Characterization of neocarcinostatin. J. Antibiot. (Tokyo), Ser. A 19, 253–259 (1966).

    CAS  Google Scholar 

  • Mandel, H. G.: Symposium on critical evaluation of cancer chemotherapy. Bull. Cancer 7, 2 (1969).

    Google Scholar 

  • Manuila, L., Moles, S., Rentchnick, P. (eds.): New trends in the treatment of cancer. In: Recent results in cancer research, vol. 8. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  • Marsden, H. B., Steward, J. K. (eds.): Tumours in children, Wilm’s tumour, p. 225–249. In: Recent results in cancer research, vol. 13. Berlin-Heidelberg-New York: Springer 1968.

    Google Scholar 

  • Mashburn, L. T., Wriston, J. C.: Tumor-inhibitory effect of l-asparaginase from Escherichia coli. Arch. Biochem. 105, 450–452 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Mathé, G., ed.: Scientific basis of cancer chemotherapy. In: Recent results in cancer research, vol. 21. Berlin-Heidelberg-New York: Springer 1969a.

    Google Scholar 

  • — Org. Dir. U. I. C. C., Advanced Course on Tumour Antigens at the Institut de Cancerologie et D’Immunogenétique, Villejuif, France, December 1969b.

    Google Scholar 

  • — Amiel, J. L., Schwarzenberg, C., Cattan, A., Schneider, M.: Adoptive immunotherapy of acute leukemia, experimental and clinical results. Cancer Res. 25, 1525–1531 (1965).

    PubMed  Google Scholar 

  • — Schwarzenberg, L., Amiel, J. L., Schneider, M., Cattan, A., Schlumberger, J. R.: The role of immunology in the treatment of leukemia and hematosarcomas. Cancer Res. 27, 2542–2553 (1967).

    PubMed  Google Scholar 

  • Mauger, A. B., Wade, R.: The synthesis of actinomycin analogues. Pt. II. Actinocylgramicidin S. J. Chem. Soc. 1406–1408 (1966).

    Google Scholar 

  • Meienhofer, J.: A total synthesis of actinomycin. Experientia (Basel) 24, 776–777 (1968).

    Article  CAS  Google Scholar 

  • Mihich, E.: Combined effects of chemotherapy and immunology against leukemia L 1210 DBA/2 mice. Cancer Res. 29, 848–855 (1969).

    PubMed  CAS  Google Scholar 

  • — Hakala, M. T.: Differences between the antitumor action of 4,4′-Di-acetyl-diphenyl-urea-bis-guanylhydrazone and methylglyoxal-bis-guanylhydrazone. Proc. Amer. Ass. Cancer Res. 9, 48, 190 (1968).

    Google Scholar 

  • Milder, J. W.: Introductory remarks about symposia in 1964, 1965 and 1967. Cancer Res. 27, 2419 (1967).

    Google Scholar 

  • Mitchell, J. S. (ed.): The treatment of cancer. Cambridge, Engl.: Cambridge University Press 1965.

    Google Scholar 

  • Modest, E. J., Foley, G. E., Farber, S.: Polypeptides and proteins as inhibitors. In: Metabolic inhibitors (R. M. Hochster and J. H. Quastel, eds.), p. 75–129. New York and London: Academic Press 1963.

    Google Scholar 

  • — Sengupta, S. K., Tinter, S. K., Trites, D. H.: Laboratories of Organic Chemistry, Children’s Cancer Res. Found., Boston, Mass.: Private Communication 1969.

    Google Scholar 

  • Mohr, O., Althoff, J., Kinzel, V., Süss, R., Volm, M.: Melanoma regression induced by “chalone”: a new tumour inhibitory principle acting in vivo. Nature (Lond.) 220, 138–139 (1968).

    Article  CAS  Google Scholar 

  • Monod, J., Changeux, J. P., Jacob, F.: Allosteric proteins and cellular control systems. J. molec. Biol. 6, 306–329 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Mühlbock, O. (Dir.): Techniques with experimental animals in cancer research. World Health Org. and Int. Agency for Res. on Cancer. Amsterdam, May 1969.

    Google Scholar 

  • Nass, M. M. K.: Mitochondrial DNA, advances, problems and goals. Science 165, 25–35 (1969).

    Article  PubMed  CAS  Google Scholar 

  • Nathanson, L., Hall, T. C., Dederick, M. M., Yount, W., Miller, S.: Initial pharmacological studies of three types of combination chemotherapy. Cancer Chemother. Rep. 50, 259–264 (1966).

    PubMed  CAS  Google Scholar 

  • Nossal, G. J. V.: The impact of immunology on the pediatrics of the future (in press). Rep. Proc. Children’s Hosp. Med. Center, 100th Anniv. Celebr. 1969.

    Google Scholar 

  • O’Bryan, R. M., Talley, R. W.: Preliminary pharmacology dose-response studies of 7α-methyl-19-nortestosterone in patients. Cancer Chemother. Rep. 50, 335–338 (1966).

    Google Scholar 

  • Ochoa, M., Jr., Hirschberg, E.: Alkylating agents in experimental chemotherapy, vol. V., pt. 1. New York: Academic Press Inc. 1967.

    Google Scholar 

  • Oettgen, H. F.: Inhibition of leukemias in man by l-asparaginase. Cancer Res. 26, 2619–2631 (1967).

    Google Scholar 

  • Ohnuma, T., Bergel, F., Bray, R. C.: Enzymes in cancer: asparaginase from chicken liver. Biochem. J. 103, 238–245 (1966).

    Google Scholar 

  • Okamoto, H., Shoin, S., Minami, M., Koshimara, S., Shimizu, R.: A Development in the Study of Anticancer Activity of Hemolytic Streptococci, SO 580, Abstr. Papers, IXth Int. Cancer Congr. Tokyo 1966.

    Google Scholar 

  • Ono, Y., Ito, Y., Maeda, H., Ishida, N.: Mode of action of neocarcinostatin: requirement of protein synthesis for neocarzinostatin-mediated DNA degradation in Sarcina lutea. Biochem. Acta 155, 616–618 (1968).

    CAS  Google Scholar 

  • Papaiannou, A. N., Volk, H.: Massive doses of Δ′-testostololactone for advanced breast cancer. Chemother. 50, 323–326 (1966).

    Google Scholar 

  • Plattner, P. A. (ed.): Chemotherapy of cancer. Amsterdam: Elsevier Publ. Co. 1964.

    Google Scholar 

  • Porter, R., Wiltshaw, E. (eds.): Methotrexate in the treatment of cancer. Bristol: J. Wright & Sons, Ltd. 1962.

    Google Scholar 

  • Pressman, D. (Chm.): Symposium on Immunological Aspects of Malignant Disease. 59th Ann. Mtg. Amer. Ass. Cancer Res., Atlantic City, 12th April 1968.

    Google Scholar 

  • Rall, D. P., Homan, E. R.: New concepts in cancer chemotherapy. Cancer Chemother. Rep. 51, 247–251 (1967).

    PubMed  CAS  Google Scholar 

  • Regelson, W.: Antimitotic activity of polyanions. In: Adv. in chemotherap. (A. Goldin, F. Hawking and R. S. Schnitzer, eds.), vol. 3, p. 303–370. New York: Academic Press 1968.

    Google Scholar 

  • — Holland, J. F., Talley, R. W.: Clinical pharmacological study of kethoxal bis-(thiosemicarbazone) in advanced cancer. Cancer Chemother. Rep. 51, 171–177 (1967).

    PubMed  CAS  Google Scholar 

  • Roberts, D., Hall, T. C.: Enzyme activity and deoxynucleoside utilization of leukemic leukocytes in relation to drug therapy and resistance. Cancer Res. 29, 166–173 (1969).

    PubMed  CAS  Google Scholar 

  • Rosenoer, V. M., Whisson, M. E.: A transplantable plasma cell tumour in the study of carcinostatic agents. Biochem. Pharmacol. 13, 589–602 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Ross, G. T., Stellbach, L., Hertz, L.: Actinomycin D in the treatment of methotrexate-resistant trophoblastic diseases in women. Cancer Res. 22, 1015–1017 (1962).

    PubMed  CAS  Google Scholar 

  • Ross, W. C. J.: Biological alkylating agents. London: Butterworth 1962.

    Google Scholar 

  • — Anti-coenzymes. Brit. Emp. Cancer Camp., Ann. Rep. 42, 81 (1964).

    Google Scholar 

  • — The preparation of some 4-substituted nicotinic acids and nicotinamides. J. chem. Soc. 1816–1821 (1966).

    Google Scholar 

  • — Some alkylating derivatives of nicotinic acids. J. med. Chem. 10, 257 (1967a).

    Article  PubMed  CAS  Google Scholar 

  • — Some 6-substituted nicotinamides. Biochem. Pharmacol. 16, 675 (1967b).

    Article  PubMed  CAS  Google Scholar 

  • — Jarman, M.: Nicotinamide ribosides. Brit. Emp. Cancer Camp., Ann. Rep. 44, 14 (1966); 45, 38 (1967).

    Google Scholar 

  • Rosso, R., Donelli, M. G., Franchi, G., Garattini, S.: Effect of Triton WR 1339 on cancer dissemination and metastasis. Europ. J. Cancer 5, 77–78 (1969).

    CAS  Google Scholar 

  • Rusconi, A., Fronzo, G. di, Dimarco, A.: Distribution of tritiated daunomycin in normal rats. Cancer Chemother. Rep. 52, 331–337 (1968).

    PubMed  CAS  Google Scholar 

  • Rytömaa, T., Kiviniemi, K.: Control of cell production in rat chloroleukaemia by means of the granulocytic chalone. Nature (Lond.) 220, 136–138 (1968a).

    Article  Google Scholar 

  • — —Control of DNA duplication in rat chloroleukaemia by means of the granulocytic chalone. Europ. J. Cancer 4, 595–606 (1968b).

    Google Scholar 

  • — —Control of granulocyte production. Cell Tissue Kinet. 1, 329–340, 341–350 (1968c).

    Google Scholar 

  • Sachs, L.: An analysis of the mechanism of carcinogenesis by polyoma virus, hydrocarbons and X-irradiation. In: Molekulare Biologie des malignen Wachstums (Holzer and Holldorf, eds.). Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Sadler, P. W.: Antiviral chemotherapy with isatin-β-thiosemicarbazone and its derivatives. In: Symposium on Drugs, Parasites and Hosts (L. G. Goodwin and R. H. Nimmo-Smith, eds.), p. 286–293. London: J. & A. Churchill, Ltd. 1962.

    Google Scholar 

  • Sahasrabudhe, M. B.: A new approach to chemotherapy and radiotherapy. J. Sci. Ind. Res. 26, 243–248 (1967).

    CAS  Google Scholar 

  • Sandford, K. K., Earle, W. R., Likely, G. D.: The growth in vitro of single isolated tissue cells. J. nat. Cancer Inst. 9, 229 (1948).

    Google Scholar 

  • Scanlon, E. T., Hawkins, R. A., Fox, W. W., Smith, W. S.: Fatal homotransplanted melanoma. Cancer (Philad.) 18, 782–794 (1965).

    Article  CAS  Google Scholar 

  • Schmidt, L. H., Fradkin, R., Sullivan, R., Flowers, A.: Comparative pharmacology of alkylating agents. Cancer Chemother. Rep., pts. I, II, and III, Suppl. 2 (Jan. 1965).

    Google Scholar 

  • Shimkin, M. B. (ed.): Proc. Amer. Ass. Cancer Res. 9, 1–83 (1968).

    Google Scholar 

  • Simnet, J. D., Fisher, J. M., Heppelstone, A. G.: Tissue specific inhibition of lung alveolar cell mitosis in organ culture. Nature (Lond.) 223, 944–946 (1969).

    Article  Google Scholar 

  • Skipper, H. E.: The effects of chemotherapy on the kinetics of leukemic cell behaviour. Cancer Res. 25, 1544–1550; Summary of informal discussion on the effects of chemotherapy on the kinetics of leucemic cell behaviour. Cancer Res. 25, 1553–1554 (1965).

    Google Scholar 

  • — Schabel, F. M., Jr., Wilcox, W. S.: On the criteria and kinetics associated with “curability” of experimental leukemias. Cancer Chemoth. Rep. 35, 3–111 (1964).

    Google Scholar 

  • Smithers, D. W.: On the nature of neoplasia in man. Edinburgh and London: E. & S. Livingstone 1964.

    Google Scholar 

  • Southam, C. M.: Evidence of immunological reactions to autochthonous cancer in man. Europ. J. Cancer 1, 173–181 (1965).

    CAS  Google Scholar 

  • — Summary: Immunology of acute leukemia and Burkitt’s tumor. Cancer Res. 27, 2554–2556 (1967).

    PubMed  CAS  Google Scholar 

  • — Co-existence of allogeneic tumour growth and homograft immunity in man. Europ. J. Cancer 4, 507–511 (1968).

    CAS  Google Scholar 

  • Squibb institute for medical research, New Brunswick, N. J., Proc. of Conference on l-Asparaginase, 14th March 1968.

    Google Scholar 

  • Stanley, W. M.: Vaccines for viral diseases of children, past, present and future. Rep. Proc. Children’s Hosp. Med. Center. 100th Anniv. Celebr. (in press) 1969.

    Google Scholar 

  • Stedman’s medical dictionary, 20th ed. London: Baillière, Tindall & Cox 1966.

    Google Scholar 

  • Stock, J. A.: Antimetabolites. In: Experimental chemotherapy, vol. IV, p. 79–237 (Schnitzer and Hawkings, eds.). New York: Academic Press, Inc. 1966a.

    Google Scholar 

  • — Antitumour antibiotics. In: Experimental chemotherapy (R. J. Schnitzer and F. Hawking, eds.), vol. IV, p. 241–377. New York: Academic Press, Inc. 1966b.

    Google Scholar 

  • — Other antitumor agents. In: Experimental chemotherapy, vol. V, pt. II, p. 334–416. New York: Academic Press 1967a.

    Google Scholar 

  • — Some thoughts on cancer chemotherapy and the future. In: Experimental Chemotherapy, vol. V, pt. II, p. 451–459. New York: Academic Press Inc. 1967b.

    Google Scholar 

  • Stoker, M.: Regulation of growth and orientation in hamster cells transformed by polyoma virus. Virology 24, 165–174 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Stoker, M., MacPherson, I.: Studies on transformation of hamster cells by polyoma virus in vitro. Virology 14, 359–370 (1961).

    Article  Google Scholar 

  • Sugihara, Y., Araki, F.: Carcinostatic substances prepared from bovine liver. Abstr. Papers SO 589, IXth Int. Cancer Congr., Tokyo 1966.

    Google Scholar 

  • Suguira, K., Brown, G. B.: Antitumor activity of purine N-oxides. Abstr. Paper p. 317 (SO 549). IXth Int. Cancer Congr., Tokyo 1966.

    Google Scholar 

  • — —Purine N-oxides. XIX. On the oncogenic derivatives of guanine and xanthine and a nononcogenic isomer of xanthine N-oxide. Cancer Res. 27, 925–931 (1967).

    Google Scholar 

  • Sullivan, M. P. (Chrm.): Symposium on Vincristine. Memphis, Tennessee.. Cancer Chemother. Rep. 52, 453–533 (1968). See also: Antitumural effects of Vinca Rosea alkaloids. In: Proc. 1st Symp. Europ. Chemother. Group, Paris, June 1965. Int. Congr. Ser. No 106 (1965).

    Google Scholar 

  • Szekerke, M., Wade, R., Bergel, F.: Cytoactive amino acids and peptides. Pt. XIV. Poly-acid copoly-amino acid derivatives of melphalan. J. chem. Soc. 1792–1795 (1968).

    Google Scholar 

  • Szent Györgyi, A.: Bioelectronics. Science 161, 988–990 (1968).

    Article  Google Scholar 

  • Tagnon, H. J.: Note. Europ. J. Cancer 4, 507 (1968).

    Google Scholar 

  • Teller, M., Suguira, K., Parham, J. C., Brown, G. B.: Oncogenicity of purine N-oxide derivatives. Proc. Amer. Ass. Cancer Res. 9, 70 (277) (1968).

    Google Scholar 

  • Thomas, H. J., Montgomery, J. A.: Complex esters of thioinosinic-(5′) acid. J. med. pharm. Chem. 5, 24–32 (1962).

    Article  CAS  Google Scholar 

  • Timmis, G. M., Williams, D. C.: Chemotherapy of cancer, the antimetabolic approach. London: Butterworths 1967.

    Google Scholar 

  • Umezawa, H.: The distribution of H-bleomycin in mouse tissue. J. Antibiotics (Tokyo) 21, 638–642 (1968).

    CAS  Google Scholar 

  • Venditti, J. M., Abbott, B. J., Dimarco, A., Goldin, A.: Effectiveness of daunomycin against experimental tumors. Cancer Chemother. Rep. 50, 659–665 (1966).

    PubMed  CAS  Google Scholar 

  • Vesely, J.: Cancerostatic effects of recently synthesized thymine mustards and their fluoro derivatives. SO 551, Abstr. Papers, IXth Int. Cancer Congr., Tokyo 1966.

    Google Scholar 

  • Wade, R.: Hormones. In: Experimental Chemotherapy, vol. V, p. 133–331 (Schnitzer and Hawkings, eds.). New York: Academic Press 1967.

    Google Scholar 

  • — Whisson, M. E., Szekerke, M.: Some serum protein nitrogen mustard complexes with high chemotherapeutic selectivity. Nature (Lond.) 215, 1303–11304 (1967).

    Article  CAS  Google Scholar 

  • Waksman, S. A.: The actinomycetes and their antibiotics. Advanc. appl. Microbiol. 5, 235–315 (1963).

    Article  CAS  Google Scholar 

  • — Furness, F. N.: The actinomycins and their importance in the treatment of tumors in animals and man. Ann. N. Y. Acad. Sci. 89, 283–486 (1960).

    Google Scholar 

  • Warburg, O.: Über die Ursache des Krebses, p. 1. In: Molekulare Biologie des malignen Wachstums (Holzer and Holldorf, eds.). Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • — Gawehn, K., Geissler, A. W., Lorenz, S.: Über die Heilung von Mäuse-Ascites-Krebs durch d-and l-Glycerinaldehyd. Z. klin. Chem. 1, 175–177 (1963).

    CAS  Google Scholar 

  • Weitzel, G. F., Schneider, D., Kummer, D., Ochs, H.: Cytostatischer Wirkungsmechanismus von Natulan. Z. Krebsforsch. 70, 354–365 (1968).

    PubMed  CAS  Google Scholar 

  • Whisson, M. E.: The interaction of tumour and embryonic tissue in vivo. In: Symposium Ciba Foundation on Cell Differentiation (A. V. S. de Reuck and J. Knight, eds.), p. 219–231. London: J. & A. Churchill, Ltd. 1967.

    Google Scholar 

  • Wolff, E., Wolff (Mme), E.: Factors of growth and maintenance of tumours as organised structures in vitro. In: Ciba Foundation Symposium on Cell Differentiation (A. V. S. de Reuck and J. Knight, eds.), p. 208–215. London: J. & A. Churchill, Ltd. 1967.

    Google Scholar 

  • Wolstenholme, G. E. W., Knight, J. (eds.): Homeostatic regulators, Joint Ciba Foundation-Wellcome Trust Symposium, Jan. 1969 (in press). London: J. & A. Churchill, Ltd. 1969.

    Google Scholar 

  • Woodruff, H. B., Miller, I. M.: Antibiotics in metabolic inhibitors (B. M. Hochster and J. H. Quastel, eds.), vol. II, p. 23–51. New York and London: Academic Press 1963.

    Google Scholar 

  • Yoshida, T.: org. chrm., Publications IXth Int. Cancer Congr., Tokyo 1966.

    Google Scholar 

  • Zilber, L. A.: An immunological approach to tumour growth control. In: Symposium on Biological Approaches to Cancer Chemotherapy (R. C. J. Harris, ed.), p. 231–243. London: Academic Press 1961.

    Google Scholar 

  • Zubrod, C. G.: Quantitative concepts in the clinical study of drugs. In: Advances in Chemotherapy, vol. 1, p. 9–34. New York and London: Academic Press 1964.

    Google Scholar 

  • — Treatment of the acute leukemias. Cancer Res. 27, 2557–2560 (1967).

    PubMed  CAS  Google Scholar 

  • — Schepartz, S., Leiter, J., Endicott, K. M., Carrese, L. M., Baker, C. G.: Program of the National Cancer Institute; history, analysis and plans. Cancer Chemother. Rep. 50, 349–540 (1966).

    Google Scholar 

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Bergel, F. (1970). Today’s carcinochemotherapy: Some of its achievements, failures and prospects. In: Reviews of Physiology, Biochemistry and Experimental Pharmacology. Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0111423

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