1. What goes up, must come down: treating the hypertensive emergency

   • P. W. de Leeuw
   • A. A. Kroon

   EDITORIAL Pages: 277 - 279

2. Assuming the worst may not be bad at all Carvedilol in heart failure treatment

   • B. M. W. Schmidt
   • C. P. Janson
   • M. Wehling

   CLINICAL TRIAL Pages: 281 - 285

3. Monitoring of proteinuria in phase I studies in healthy male subjects

   • G. Lemm
   • J. Küppers
   • J. Kuhlmann

   CLINICAL TRIALS Pages: 287 - 294

4. A comparison of the antihypertensive efficacy and safety of felodipine IV and nifedipine IV in patients with hypertensive crisis or emergency not responding to oral nifedipine

   • T. Risler
   • R. Bohm
   • C. M. Erley

   PHARMACODYNAMICS Pages: 295 - 298

5. Effect of omeprazole and cimetidine on plasma aldosterone response to angiotensin II

   • M. Sasaki
   • A. Maeda
   • A. Fujimura

   PHARMACODYNAMICS Pages: 299 - 302

6. Effect of meal timing on the kinetic-dynamic profile of levodopa/carbidopa controlled is release in parkinsonian patients

   • M. Contin
   • R. Riva
   • A. Baruzzi

   PHARMACODYNAMICS Pages: 303 - 308

7. Psychomotor performance: investigating the dose-response relationship for caffeine and theophylline in elderly volunteers

   • C. A. Bryant
   • A. Farmer
   • S. H. D. Jackson

   PHARMACODYNAMICS Pages: 309 - 313

8. A Bayesian neural network method for adverse drug reaction signal generation

   • A. Bate
   • M. Lindquist
   • R. M. De Freitas

   PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Pages: 315 - 321

9. Loop diuretics in patients aged 75 years or older: general practitioners' assessment of indications and possibilities for withdrawal

   • D. J. W. van Kraaij
   • R. W. M. M. Jansen
   • W. H. L. Hoefnagels

   PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Pages: 323 - 327

10. Increasing awareness of and behaviour towards periconceptional folic acid consumption in The Netherlands from 1994 to 1995

    • L. T. W. de Jong-van den Berg
    • H. E. K. de Walle
    • M. C. Cornel

    PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Pages: 329 - 331

11. Prescription changes and drug costs at the Interface between primary and specialist care

    • D. Bijl
    • E. Van Sonderen
    • F. M. Haaijer-Ruskamp

    PHARMACOEPIDEMIOLOGY AND PRESCRIPTION Pages: 333 - 336

12. The effect of grapefruit juice on the pharmacokinetics of orally administered verapamil

    • R. Zaidenstein
    • V. Dishi
    • A. Golik

    PHARMACOKINETICS AND DISPOSITION Pages: 337 - 340

13. Pharmacokinetics and safety of candesartan cilexetil in subjects with normal and impaired liver function

    • J. F. W. Hoogkamer
    • C. H. Kleinbloesem
    • E. Weidekamm

    PHARMACOKINETICS AND DISPOSITION Pages: 341 - 345

14. Pharmacokinetic alterations of quinapril during repeated treatment in elderly subjects

    • M. Sasaki
    • A. Maeda
    • A. Fujimura

    PHARMACOKINETICS AND DISPOSITION Pages: 347 - 349

15. Effect of dimethicone (polysilane gel) on the stereoselective pharmacokinetics of ketoprofen

    • N. Presle
    • F. Lapicque
    • P. Netter

    PHARMACOKINETICS AND DISPOSITION Pages: 351 - 354

16. Tiagabine, a novel antiepileptic agent: lack of pharmacokinetic interaction with digoxin

    • S. Snel
    • J. A. Jansen
    • P. N. M. van Heiningen

    PHARMACOKINETICS AND DISPOSITION Pages: 355 - 357

17. A model for the determination of carbamazepine clearance in children on mono- and polytherapy

    • A. L. Gray
    • J. H. Botha
    • R. Miller

    PHARMACOKINETICS AND DISPOSITION Pages: 359 - 362

18. The pharmacokinetics of lamivudine in patients with impaired hepatic function

    • M. A. Johnson
    • J. Horak
    • P. Breuel

    PHARMACOKINETICS AND DISPOSITION Pages: 363 - 366

19. Pharmacokinetics of tamsulosin in subjects with normal and varying degrees of impaired renal function: an open-label single-dose and multiple-dose study

    • M. Wolzt
    • V. Fabrizii
    • H.-G. Eichler

    PHARMACOKINETICS AND DISPOSITION Pages: 367 - 373