Abstract
Atherosclerosis progression is associated with a complex array of cellular processes in the arterial wall, including endothelial cell activation/dysfunction, chemokine-driven recruitment of immune cells, differentiation of monocytes to macrophages and their subsequent transformation into lipid laden foam cells, activation of inflammasome and pro-inflammatory signaling, and migration of smooth muscle cells from the media to the intima. The use of in vitro model systems has considerably advanced our understanding of these atherosclerosis-associated processes and they are also often used in drug discovery and other screening platforms. This chapter will describe key in vitro model systems employed frequently in atherosclerosis research.
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Acknowledgments
We thank the British Heart Foundation for financial support (grants PG/16/25/32097 and FS/17/75/33257). AI and FA received PhD studentships from the Kingdom of Saudi Arabia; JC received PhD studentship from China Scholarship Council; and SA received PhD studentship from Oman Government.
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Ramji, D.P., Ismail, A., Chen, J., Alradi, F., Al Alawi, S. (2022). Survey of In Vitro Model Systems for Investigation of Key Cellular Processes Associated with Atherosclerosis. In: Ramji, D. (eds) Atherosclerosis. Methods in Molecular Biology, vol 2419. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1924-7_3
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DOI: https://doi.org/10.1007/978-1-0716-1924-7_3
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