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An Overview of HLA Typing for Hematopoietic Stem Cell Transplantation

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Bone Marrow and Stem Cell Transplantation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1109))

Abstract

The selection of a related or an unrelated hematopoietic stem cell donor for a patient requires accurate matching of human leukocyte antigen (HLA) genes in order to maximize the beneficial effects of the transplant. There are various different factors a laboratory must consider in order to achieve an HLA type including the number of samples being processed, level of resolution to be achieved, cost of providing the various tests, and turnaround time required. Each method has its advantages and disadvantages, and in most laboratories, a combination of methods may be used.

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Acknowledgments

Dr. Raymond Fernando and Mr. Franco Tavarozzi are thanked for providing Fig. 2.

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Authors and Affiliations

  1. Anthony Nolan Research Institute, University College London, London, UK

    Katy Latham & J. Alejandro Madrigal

  2. Histocompatibility and Immunogenetics, Greater Glasgow and Clyde, Gartnavel General Hospital, Glasgow, UK

    Ann-Margaret Little

Authors
  1. Katy Latham
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  2. Ann-Margaret Little
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  3. J. Alejandro Madrigal
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Editor information

Editors and Affiliations

  1. Department of Hematology, Ankara University, Ankara, Turkey

    Meral Beksaç

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Latham, K., Little, AM., Madrigal, J.A. (2014). An Overview of HLA Typing for Hematopoietic Stem Cell Transplantation. In: Beksaç, M. (eds) Bone Marrow and Stem Cell Transplantation. Methods in Molecular Biology, vol 1109. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9437-9_5

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  • DOI: https://doi.org/10.1007/978-1-4614-9437-9_5

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4614-9436-2

  • Online ISBN: 978-1-4614-9437-9

  • eBook Packages: Springer Protocols

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