Abstract
Fruit flies (Drosophila melanogaster) have been widely used to study the cellular and molecular basis of human neurodegenerative disease. The biological similarities between the human and the fly have been explored successfully to further investigate the pathological basis of Alzheimer’s disease (AD). Here, we discuss transgenic Drosophila models systems and the methodologies that have been employed in the study of AD.
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Acknowledgement
This work was supported by the Korea-UK Alzheimer’s disease research consortium program from the Ministry of Health and Welfare, Republic of Korea (J.Y.L.) and the Medical Research Council (UK) (G0700990; D.C.C.) and the Wellcome Trust (082604/2/07/Z; D.C.C.). D.C.C. is an Alzheimer’s Research UK Senior Research Fellow (ART-SRF2010-2).
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Lim, J.Y., Ott, S., Crowther, D.C. (2016). Drosophila melanogaster as a Model for Studies on the Early Stages of Alzheimer’s Disease. In: Castrillo, J., Oliver, S. (eds) Systems Biology of Alzheimer's Disease. Methods in Molecular Biology, vol 1303. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2627-5_13
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DOI: https://doi.org/10.1007/978-1-4939-2627-5_13
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