Abstract
The measurement of mechanical vibrations within the living cochlea is critical to understanding the first nonlinear steps in auditory processing, hair cell stimulation, and cochlear amplification. However, it has proven to be a challenging endeavor. This chapter describes how optical coherence tomography (OCT) can be used to measure vibrations within the tissues of the organ of Corti. These experimental measurements can be performed within the unopened cochlea of living mice routinely and reliably.
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Acknowledgements
The authors appreciate the assistance of Jinkyung Kim, Hee Yoon Lee, Xiao Fang Liu, Patrick Raphael, and Anping Xia. This project was funded by NIH grants DC014450, DC013774, DC010363, and the Stanford CNC Seed Grant Program.
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Jawadi, Z., Applegate, B.E., Oghalai, J.S. (2016). Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo. In: Sokolowski, B. (eds) Auditory and Vestibular Research. Methods in Molecular Biology, vol 1427. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3615-1_24
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DOI: https://doi.org/10.1007/978-1-4939-3615-1_24
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