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Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy Fibers in the Mouse

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Systems Genetics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1488))

Abstract

This chapter describes the genetic analysis of a morphometric neuroanatomic trait. We used the extended BXD family of recombinant inbred mouse strains with the intent to analyze the genetic bases of heritable differences in hippocampal neurocircuitry and to identify Quantitative Trait Loci that underlie these variations. A detailed description of a GeneNetwork analysis is provided using data for the intra- and infrapyramidal mossy fiber (IIPMF) terminal fields which are strongly correlated with spatial navigation/radial maze learning.

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Acknowledgements

The data used in this book chapter as an example of the analysis of a neuroanatomical trait were part of a larger study that was originally published in an earlier article [24]. This work was supported by a grant from NIMH (R01MH072920) to W.E.C. Dr. Rob Williams (University of Tennessee Health Sciences Center, supported by grants from NIAAA-U01 AA016662 and U01 AA013499) and Drs Sabine Spijker and August B. Smit (Free University of Amsterdam) from the Neuro-BSIK Mouse Phenomics Consortium (BSIK03053) generously provided breeders of several BXD strains (for the origin of the latter strains, see [26]). We thank Raphael Pineau and Laetitia Medan for expert animal care and Marie-Paule Algéo, Brice Bonheur, and Alexis Cornuez for carrying out the histology and morphometry.

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Authors and Affiliations

  1. Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287, University of Bordeaux, Bat B2 – Allée Geoffroy St. Hilaire, CS 50023, Pessac, France

    Anna Delprato & Wim E. Crusio

  2. CNRS, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, UMR 5287, Pessac, France

    Anna Delprato & Wim E. Crusio

  3. BioScience Project, 3266, Wakefield, MA, 01880, USA

    Anna Delprato & Wim E. Crusio

Authors
  1. Anna Delprato
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  2. Wim E. Crusio
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Corresponding author

Correspondence to Anna Delprato .

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Editors and Affiliations

  1. Department of Infection Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Niedersachsen, Germany

    Klaus Schughart

  2. Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA

    Robert W. Williams

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Delprato, A., Crusio, W.E. (2017). Genetic Dissection of Variation in Hippocampal Intra- and Infrapyramidal Mossy Fibers in the Mouse. In: Schughart, K., Williams, R. (eds) Systems Genetics. Methods in Molecular Biology, vol 1488. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-6427-7_19

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  • DOI: https://doi.org/10.1007/978-1-4939-6427-7_19

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-6425-3

  • Online ISBN: 978-1-4939-6427-7

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