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Metabolomics as a Tool to Understand Pathophysiological Processes

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Clinical Metabolomics

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1730))

Abstract

Multiple diseases have a strong metabolic component, and metabolomics as a powerful phenotyping technology, in combination with orthogonal biological and clinical approaches, will undoubtedly play a determinant role in accelerating the understanding of mechanisms that underlie these complex diseases determined by a set of genetic, lifestyle, and environmental exposure factors. Here, we provide several examples of valuable findings from metabolomics-led studies in diabetes and obesity metabolism, neurodegenerative disorders, and cancer metabolism and offer a longer term vision toward personalized approach to medicine, from population-based studies to pharmacometabolomics.

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Authors and Affiliations

  1. Metabolomics Platform, Faculty of Biology and Medicine, University of Lausanne, Rue du Bugnon 19, 1005, Lausanne, Switzerland

    Julijana Ivanisevic

  2. Unit of Toxicology, CURML, CHUV Lausanne University Hospital, HUG Geneva University Hospitals, Vulliette 04, 1000, Lausanne, Switzerland

    Aurelien Thomas

  3. Faculty of Biology and Medicine, University of Lausanne, Vulliette 04, 1000, Lausanne, Switzerland

    Aurelien Thomas

Authors
  1. Julijana Ivanisevic
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  2. Aurelien Thomas
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Corresponding authors

Correspondence to Julijana Ivanisevic or Aurelien Thomas .

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Editors and Affiliations

  1. Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

    Martin Giera

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Ivanisevic, J., Thomas, A. (2018). Metabolomics as a Tool to Understand Pathophysiological Processes. In: Giera, M. (eds) Clinical Metabolomics. Methods in Molecular Biology, vol 1730. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7592-1_1

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  • DOI: https://doi.org/10.1007/978-1-4939-7592-1_1

  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7591-4

  • Online ISBN: 978-1-4939-7592-1

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