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Methionine Gamma Lyase from Clostridium sporogenes Increases the Anticancer Efficacy of Doxorubicin on A549 Cancer Cells In Vitro and Human Cancer Xenografts

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Methionine Dependence of Cancer and Aging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1866))

Abstract

The anticancer efficacy of methionine γ-lyase (MGL) from Clostridium sporogenes (C. sporogenes) is described. MGL was active against cancer cells in vitro and in vivo. Doxorubicin (DOX) and MGL were more effective on A549 human lung-cancer growth inhibition than either agent alone in vitro and in vivo.

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Authors and Affiliations

  1. Laboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Moscow, Russia

    V. S. Pokrovsky, N. Yu. Anisimova & D. Zh. Davydov

  2. Department of Biochemistry, People’s Friendship University (RUDN University), Moscow, Russia

    V. S. Pokrovsky

  3. State Research Institute of Genetics and Selection of Industrial Microorganisms, Moscow, Russia

    S. V. Bazhenov, N. V. Bulushova, G. B. Zavilgelsky, V. Y. Kotova & I. V. Manukhov

  4. Laboratory of Molecular Genetics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, Russia

    S. V. Bazhenov & I. V. Manukhov

Authors
  1. V. S. Pokrovsky
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  2. N. Yu. Anisimova
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  3. D. Zh. Davydov
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  4. S. V. Bazhenov
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  5. N. V. Bulushova
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  6. G. B. Zavilgelsky
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  7. V. Y. Kotova
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  8. I. V. Manukhov
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Editors and Affiliations

  1. AntiCancer, Inc., San Diego, CA, USA

    Robert M. Hoffman

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Pokrovsky, V.S. et al. (2019). Methionine Gamma Lyase from Clostridium sporogenes Increases the Anticancer Efficacy of Doxorubicin on A549 Cancer Cells In Vitro and Human Cancer Xenografts. In: Hoffman, R. (eds) Methionine Dependence of Cancer and Aging. Methods in Molecular Biology, vol 1866. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8796-2_18

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  • DOI: https://doi.org/10.1007/978-1-4939-8796-2_18

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8795-5

  • Online ISBN: 978-1-4939-8796-2

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