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Predicting Protein–Protein Interactions Using SPRINT

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Protein-Protein Interaction Networks

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2074))

Abstract

Understanding protein–protein interactions (PPIs) is vital to reveal the function mechanisms in cells. Thus, predicting and identifying PPIs is one of the fundamental problems in system biology. Various high-throughput experimental and computation methods have been developed to predict PPIs. Here, we provide a straightforward guide of using the program “SPRINT” to predict the PPIs on an interactome level in an organism. First, some installation guides and input file formats are described. Then, the commands and options to run SPRINT are discussed with examples. In addition, some notes on possible extended installation and usage of SPRINT are given.

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Acknowledgements

L.I. has been partially supported by a Discovery Grant and a Research Tools and Instruments Grant from the Natural Sciences and Engineering Research Council of Canada (NSERC). We would like to thank the support from Robert and Ruth Lumsden Graduate Awards that is awarded to Y.L.

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Authors and Affiliations

  1. Department of Computer Science, The University of Western Ontario, London, ON, Canada

    Yiwei Li & Lucian Ilie

Authors
  1. Yiwei Li
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  2. Lucian Ilie
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Corresponding author

Correspondence to Lucian Ilie .

Editor information

Editors and Affiliations

  1. Gene Center, Ludwig-Maximilians-Universität München, München, Germany

    Stefan Canzar

  2. Gene Center, Ludwig-Maximilians-Universität München, München, Germany

    Francisca Rojas Ringeling

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Li, Y., Ilie, L. (2020). Predicting Protein–Protein Interactions Using SPRINT. In: Canzar, S., Ringeling, F. (eds) Protein-Protein Interaction Networks. Methods in Molecular Biology, vol 2074. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9873-9_1

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  • DOI: https://doi.org/10.1007/978-1-4939-9873-9_1

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9872-2

  • Online ISBN: 978-1-4939-9873-9

  • eBook Packages: Springer Protocols

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