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Mass Spectrometry of Nucleotides and Oligonucleotides

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Protocols for Oligonucleotide Conjugates

Part of the book series: Methods in Molecular Biology ((MIMB,volume 26))

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Abstract

The application of mass spectrometry (MS) to the structural analysis of large biopolymers, such as nucleic acids, combines the desirable characteristics of low-level detectability with high selectivity. Current MS techniques are capable of providing mol wt and structurally specific information with submicrogram quantities of sample.

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  1. Department of Pharmaceutical Sciences, The Universit of Arizona Health Sciences Center, Tucson, AZ

    Thomas D. McClure & Karl H. Schram

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© 1994 Humana Press Inc., Totowa, NJ

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McClure, T.D., Schram, K.H. (1994). Mass Spectrometry of Nucleotides and Oligonucleotides. In: Protocols for Oligonucleotide Conjugates. Methods in Molecular Biology, vol 26. Humana Press. https://doi.org/10.1007/978-1-59259-513-6_13

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  • DOI: https://doi.org/10.1007/978-1-59259-513-6_13

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-252-1

  • Online ISBN: 978-1-59259-513-6

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