Summary
The variety of animal models used in the study of alcoholic liver disease reflects the formidable task of developing a model that replicates the human disease. We show that oral feeding of fatty acids derived from fish oil and ethanol induces fatty liver, necrosis, inflammation, and fibrosis. Together with the study of oxidative and nitrosative stress markers, cytokines, proteasome function, and protein studies, this model has provided an inexpensive and technically simple method of establishing pathological alcoholic liver injury.
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References
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Acknowledgments
The authors gratefully acknowledge the support of the National Institutes of Health (grant to A.A.N.) and grants from the Committee of Research and Conference Grants, The University of Hong Kong.
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© 2008 Humana Press, a part of Springer Science+Business Media, LLC
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Tipoe, G.L., Liong, E.C., Leung, TM., Nanji, A.A. (2008). A Voluntary Oral-feeding Rat Model for Pathological Alcoholic Liver Injury. In: Nagy, L.E. (eds) Alcohol. Methods in Molecular Biology™, vol 447. Humana Press. https://doi.org/10.1007/978-1-59745-242-7_2
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DOI: https://doi.org/10.1007/978-1-59745-242-7_2
Publisher Name: Humana Press
Print ISBN: 978-1-58829-906-2
Online ISBN: 978-1-59745-242-7
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