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Clinical, Epidemiological, and Laboratory Aspects of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections

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Methicillin-Resistant Staphylococcus aureus (MRSA) Protocols

Part of the book series: Methods in Molecular Biology ((MIMB,volume 391))

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major pathogen responsible for both hospital- and community-onset disease. Resistance to methicillin in S. aureus is mediated by PBP2a, a penicillin-binding protein with low affinity to β-lactams, encoded by the mecA gene. Accurate susceptibility testing of S. aureus isolates and screening of patients for colonization with MRSA are important tools to limit the spread of this organism. This review focuses on the clinical significance of MRSA infections and new approaches for the laboratory diagnosis and epidemiological typing of MRSA strains.

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Authors and Affiliations

  1. Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC

    Elizabeth Palavecino

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  1. Elizabeth Palavecino
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  1. Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, MN

    Yinduo Ji

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Palavecino, E. (2007). Clinical, Epidemiological, and Laboratory Aspects of Methicillin-Resistant Staphylococcus aureus (MRSA) Infections. In: Ji, Y. (eds) Methicillin-Resistant Staphylococcus aureus (MRSA) Protocols. Methods in Molecular Biology, vol 391. Humana Press. https://doi.org/10.1007/978-1-59745-468-1_1

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  • DOI: https://doi.org/10.1007/978-1-59745-468-1_1

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