Abstract
This chapter describes the manufacturing process to a certain level for a possible oligonucleotide cargo and a peptide API in a multi-kilogram scale from a manufacture’s point of view. In the concluding remarks, possible conjugation methods will be discussed from an industrial-scale perspective.
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Acknowledgments
The authors thank Isaiah Cedillo and Kent VanSooy of Isis Pharmaceuticals, Inc. for their assistance.
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Tedebark, U., Scozzari, A., Werbitzky, O., Capaldi, D., Holmberg, L. (2011). Industrial-Scale Manufacturing of a Possible Oligonucleotide Cargo CPP-Based Drug. In: Langel, Ü. (eds) Cell-Penetrating Peptides. Methods in Molecular Biology, vol 683. Humana Press. https://doi.org/10.1007/978-1-60761-919-2_36
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DOI: https://doi.org/10.1007/978-1-60761-919-2_36
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