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Modeling Focal Cerebral Ischemia In Vivo

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Neurodegeneration

Part of the book series: Methods in Molecular Biology ((MIMB,volume 793))

Abstract

Ischemic stroke is among the leading causes of mortality and long-term disability in the western world. Despite enormous research activities in the last decades, current therapeutic options for acute stroke patients are still very limited. Reliable and realistic in vivo animal models represent sine qua non for ­successful translation from bench to bedside. To date, several animal models of focal and global cerebral ischemia have been developed to mimic the clinical situation in humans as accurately as possible. This chapter focuses on models of focal cerebral ischemia, in particular on the most commonly used model: the intraluminal filament model of middle cerebral artery occlusion. The main objective is to provide a detailed instruction manual for researchers interested in learning this technique.

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Authors and Affiliations

  1. Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY, USA

    Katherine Jackman, Alexander Kunz & Costantino Iadecola

Authors
  1. Katherine Jackman
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  2. Alexander Kunz
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  3. Costantino Iadecola
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Corresponding author

Correspondence to Costantino Iadecola .

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Editors and Affiliations

  1. Weill Medical College, Dept. Neurology & Neuroscience, Cornell University, East 68th St. 525, New York, 10065, New York, USA

    Giovanni Manfredi

  2. York Avenue 1300, New York, 10065, New York, USA

    Hibiki Kawamata

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Jackman, K., Kunz, A., Iadecola, C. (2011). Modeling Focal Cerebral Ischemia In Vivo. In: Manfredi, G., Kawamata, H. (eds) Neurodegeneration. Methods in Molecular Biology, vol 793. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-328-8_13

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  • DOI: https://doi.org/10.1007/978-1-61779-328-8_13

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61779-327-1

  • Online ISBN: 978-1-61779-328-8

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