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A Mouse Model of Staphylococcus Catheter-Associated Biofilm Infection

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Staphylococcus Epidermidis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1106))

Abstract

Biofilms are adherent communities of bacteria contained within a complex matrix. Staphylococcal species are frequent etiological agents of device-associated biofilm infections in humans that are highly recalcitrant to antimicrobial therapy and alter host immune responses to facilitate bacterial persistence. Here we describe a mouse model of catheter-associated biofilm infection, which can be utilized to investigate the importance of various staphylococcal determinants on disease progression as well as the host immune response to staphylococcal biofilms.

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Acknowledgments

This work was supported by the NIH National Institute of Allergy and Infectious Disease (NIAID) P01 AI083211 Project 4 to T.K.

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Authors and Affiliations

  1. Department of Pathology and Microbiology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, NE, USA

    Cortney E. Heim, Mark L. Hanke & Tammy Kielian

Authors
  1. Cortney E. Heim
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  2. Mark L. Hanke
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  3. Tammy Kielian
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Editor information

Editors and Affiliations

  1. Department of Pathology and Microbiology, Center for Staphylococcal Research, University of Nebraska Medical Center, Omaha, Nebraska, USA

    Paul D. Fey

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Heim, C.E., Hanke, M.L., Kielian, T. (2014). A Mouse Model of Staphylococcus Catheter-Associated Biofilm Infection. In: Fey, P. (eds) Staphylococcus Epidermidis. Methods in Molecular Biology, vol 1106. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-736-5_17

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  • DOI: https://doi.org/10.1007/978-1-62703-736-5_17

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-735-8

  • Online ISBN: 978-1-62703-736-5

  • eBook Packages: Springer Protocols

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