Abstract
Most neurotransmitters, hormones, and growth factors that cause alterations in the rate of synthesis of intracellular messengers interact with cell surface receptors that are members of a family of single polypeptide proteins. Secondary and tertiary structure predictions for such receptors indicate that they are glycoproteins in which highly hydrophobic blocks of amino acids produce seven trans-plasma membrane-spanning elements. In all known cases, such receptors are required to interact with members of a family of heterotrimeric guanine nucleotide-binding proteins (G proteins) before agonist-induced alterations in the enzymatic activity of intracellular messenger-generating systems can be detected.
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Milligan, G. (1992). Identification and Analysis of Function of Heterotrimeric Guanine Nucleotide-Binding Proteins Expressed in Neural Tissue. In: Boulton, A.A., Baker, G.B., Taylor, C.W. (eds) Intracellular Messengers. Neuromethods, vol 20. Humana Press. https://doi.org/10.1385/0-89603-207-8:1
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