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Morphometry of Rectal Mucosa

  • Protocol
Celiac Disease

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 41))

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Abstract

The diagnosis of many gastrointestinal disorders is made by assessing lesions in an endoscopic mucosal biopsy subjectively, or by objective parameters and morphometric techniques (1–4). Morphometry was first introduced into pathology 80 yr ago. It arose from doubts about qualitative observations and the need to correlate changes in morphology with function (5,6). The quality of the results of morphometry is mainly affected by the preparation of the specimens. Since biological structures such as mucosae are highly organized structurally and, in mathematical terms, are extremely anisotropic, a proper allowance for the orientation of the measured structures must be made. Thus, in comparative morphometric studies, it is essential to ensure that only sections obtained in proper and consistent orientation are used (2,7,8).

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Author information

Authors and Affiliations

  1. Department of Pathology, University of Ankara Medical School, Ankara, Turkey

    Arzu Ensari

  2. Department of Medicine, University of Manchester, Hope Hospital, Salford, UK

    Michael N. Marsh

  3. University Department of Medicine, Hope Hospital, Salford, UK

    Peter T. Crowe & Kieran Moriarty

Authors
  1. Arzu Ensari
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  2. Michael N. Marsh
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  3. Peter T. Crowe
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  4. Kieran Moriarty
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of Manchester, Salford, UK

    Michael N. Marsh MD, DSc, FRCP

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© 2000 Humana Press Inc., Totowa, NJ

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Ensari, A., Marsh, M.N., Crowe, P.T., Moriarty, K. (2000). Morphometry of Rectal Mucosa. In: Marsh, M.N. (eds) Celiac Disease. Methods in Molecular Medicine, vol 41. Humana Press. https://doi.org/10.1385/1-59259-082-9:147

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  • DOI: https://doi.org/10.1385/1-59259-082-9:147

  • Publisher Name: Humana Press

  • Print ISBN: 978-0-89603-650-5

  • Online ISBN: 978-1-59259-082-7

  • eBook Packages: Springer Protocols

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