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Neuroendocrine Phenotype of Small Cell Lung Cancer

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Lung Cancer

Part of the book series: Methods in Molecular Medicine™ ((MIMM,volume 74))

Abstract

Human lung cancers are divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), the two types having distinct clinical, histological, and biological features. Clinically, SCLC tends to present as a disseminated cancer that is not amenable to surgical resection and is treated with systemic chemotherapy and/or radiotherapy. SCLC cells typically contain dense neurosecretory granules measuring 80-90 nm in diameter. The granules contain hormones and neuropeptides that biologically characterize the neuroendocrine phenotype of SCLC. Specific neuropeptides and other neuroendocrine markers are discussed here, both in the context of their biological implications in SCLC, and for their potential as specific markers of disease and neuroendocrine progression.

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Authors and Affiliations

  1. Departments of Physiology and Human Anatomy, University of Liverpool, Liverpool, UK

    Judy M. Coulson

  2. Academic Unit of Clinical Oncology, University of Nottingham; Nottingham City Hospital, Nottingham, UK

    Marta Ocejo-Garcia & Penella J. Woll

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  1. Judy M. Coulson
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  2. Marta Ocejo-Garcia
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  3. Penella J. Woll
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  1. Children’s Hospital, Los Angeles, CA, USA

    Barbara Driscoll PhD

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Coulson, J.M., Ocejo-Garcia, M., Woll, P.J. (2003). Neuroendocrine Phenotype of Small Cell Lung Cancer. In: Driscoll, B. (eds) Lung Cancer. Methods in Molecular Medicine™, vol 74. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-323-2:61

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  • DOI: https://doi.org/10.1385/1-59259-323-2:61

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-0-89603-985-8

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