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Traditional and Established Indicators of Prognosis and Treatment Success

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Breast Cancer Research Protocols

Part of the book series: Methods in Molecular Medicine ((MIMM,volume 120))

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Summary

The outcome of breast cancer in an individual patient can be predicted by assessing a range of factors relating to the particular cancer. This assessment can be used to select treatments that are most likely to be successful, and to avoid futile or unnecessarily aggressive procedures.

Histopathological examination provides information on most of these factors. The most useful prognostic indicators in standard use are currently tumor stage, tumor grade, completeness of surgical excision, and estogen receptor status.

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References

  1. Fitzgibbons, P. L., Page, D. L., Weaver, D., et al. (2000) Prognostic factors in breast cancer. College of American Pathologists consensus statement 1999. Arch. Pathol. Lab. Med. 124, 966–978.

    PubMed  CAS  Google Scholar 

  2. Sobin, L. H. and Wittekind, C. H., eds. (2002) TNM Classification of Malignant Tumours, 6th Edition. Wiley-Liss, New York, NY.

    Google Scholar 

  3. Carter, C. L., Allen, C., and Hensen, D. E. (1989) Relation of tumor size, lymph node status and survival in 24,740 breast cancer cases. Cancer 63, 181–187.

    Article  PubMed  CAS  Google Scholar 

  4. Hensen, D. E., Ries, L., Freedman, L. S., and Carriaga, M. (1991) Relationship among outcome, stage of disease and histologic grade for 22,616 cases of breast cancer. Cancer 68, 2142–2149.

    Article  Google Scholar 

  5. Veronesi, U., Galimberti, V., Zurrida, M., et al. (1993) Prognostic significance of number and level of axillary node metastases in breast cancer. Breast 2, 224–228.

    Article  Google Scholar 

  6. National Coordinating Group for Breast Cancer Screening Pathology (2003) Pathology reporting in breast cancer screening. NHSBSP Publications, Sheffield, UK.

    Google Scholar 

  7. Weaver, D. L. (2003) Sentinel lymph nodes and breast carcinoma. Which micrometastases are clinically significant? Am. J. Surg. Pathol. 27, 842–845.

    Article  PubMed  Google Scholar 

  8. Pinder, S., Ellis, I. O., O’Rourke, S., et al. (1994) Pathological prognostic factors in breast cancer. III. Vascular invasion: relationship with recurrence and survival in a large series with long-term follow-up. Histopathology 24, 41–47.

    Article  PubMed  CAS  Google Scholar 

  9. Perrone, F., Carlomagno, C., Lauria, R., et al. (1996) Selecting high-risk early breast cancer patients: what to add to the number of metastatic nodes? Eur. J. Cancer 32A, 41–46.

    Article  PubMed  CAS  Google Scholar 

  10. Elston, C. W. and Ellis, I. O. (1991) Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 19, 403–410.

    Article  PubMed  CAS  Google Scholar 

  11. Pereira, H., Pinder, S. E., Sibbering, D., M., et al. (1995) Pathological prognostic factors in breast cancer IV: Should you be a typer or a grader? A comparative study of two histological prognostic features in operable breast carcinoma. Histopathology 27, 219–226.

    Article  PubMed  CAS  Google Scholar 

  12. Should aromatase inhibitors replace tamoxifen? (2003) Drug Ther. Bull. 41, 57–59.

    Google Scholar 

  13. Leake, R., Barnes, D., Pinder, S., et al. (2000) Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. UK Receptor Group, UK NEQAS, The Scottish Breast Cancer Pathology Group, and The Receptor and Biomarker Study Group of the EORTC. J. Clin. Pathol. 53, 634–635.

    Article  PubMed  CAS  Google Scholar 

  14. Singletary, S. E. (2002) Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy. Am. J. Surg. 184, 383–393.

    Article  PubMed  Google Scholar 

  15. Jensen, R. A. and Page, D. L. (2003) Ductal carcinoma in situ of the breast. Impact of pathology on therapeutic decisions. Am. J. Surg. Pathol. 27, 828–831.

    Article  PubMed  Google Scholar 

  16. Mokbel, K. (2003) Towards optimal management of ductal carcinoma in situ of the breast. Eur. J. Surg. Oncol. 29, 191–197.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cellular Pathology, The John Radcliffe Hospital, Oxford, UK

    Derek E. Roskell & Ian D. Buley

Authors
  1. Derek E. Roskell
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  2. Ian D. Buley
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Editor information

Editors and Affiliations

  1. School of Biological and Molecular Sciences, Oxford Brookes University, Headington, Oxford, UK

    Susan A. Brooks

  2. Medical Oncology Unit, The Churchill Hospital, Headington, Oxford, UK

    Adrian Harris

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© 2006 Humana Press Inc.

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Roskell, D.E., Buley, I.D. (2006). Traditional and Established Indicators of Prognosis and Treatment Success. In: Brooks, S.A., Harris, A. (eds) Breast Cancer Research Protocols. Methods in Molecular Medicine, vol 120. Humana Press, Totowa, NJ. https://doi.org/10.1385/1-59259-969-9:79

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  • DOI: https://doi.org/10.1385/1-59259-969-9:79

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-58829-191-2

  • Online ISBN: 978-1-59259-969-1

  • eBook Packages: Springer Protocols

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